SBIO vs CANC

Comparison between ALPS MEDICAL BREAKTHROUGHS ETF (SBIO, ETF) and TEMA ONCOLOGY ETF (CANC, ETF).

Both SBIO and CANC are from the Healthcare sector.

5-Year PerformanceSBIO has outperformed CANC, delivering a return of +7.3% compared to -7.4%

SBIO vs CANC - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SBIO(ETF)	CANC(ETF)
Net Assets	$190M	$190M
Expense Ratio	0.50%	0.75%
Max Drawdown	63.06%	97.53%
Sharpe Ratio	2.26	1.94
5Y Beta	1.01	0.74
P/E Ratio	-5.74	-28.60
5Y Dividends CAGR	9.24%	N/A
5Y EPS CAGR	N/A	10.35%
Debt to Equity	0.42%	66.51%
P/S Ratio	8.00	8.97
P/B Ratio	4.14	7.20

Net Assets

Winner

SBIO

$190M

CANC

$190M

Expense Ratio

Winner

SBIO

0.50%

CANC

0.75%

Max Drawdown

Winner

SBIO

63.06%

CANC

97.53%

Sharpe Ratio

Winner

SBIO

2.26

CANC

1.94

5Y Beta

SBIO

1.01

Winner

CANC

0.74

P/E Ratio

SBIO

-5.74

Winner

CANC

-28.60

5Y Dividends CAGR

SBIO

9.24%

CANC

N/A

5Y EPS CAGR

SBIO

N/A

CANC

10.35%

Debt to Equity

Winner

SBIO

0.42%

CANC

66.51%

P/S Ratio

Winner

SBIO

8.00

CANC

8.97

P/B Ratio

Winner

SBIO

4.14

CANC

7.20

SBIO vs CANC - Holdings Comparison

SBIO and CANC have 14 common holdings. Overlap is 14.35%

SBIO's top 25 holdings weight is 56.86%. CANC's top 25 holdings weight is 74.89%.

Rank	SBIO	CANC
#1	CRINETICS PHARMACEUTICALS INC (CRNX) - 4.38%	REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 6.05%
#2	APOGEE THERAPEUTICS INC (APGE) - 4.11%	ELI LILLY AND CO (LLY) - 4.93%
#3	XENON PHARMACEUTICALS INC (XENE) - 3.41%	COGENT BIOSCIENCES INC (COGT) - 4.92%
#4	CG ONCOLOGY INC (CGON) - 3.22%	NOVARTIS AG REGISTERED SHARES (n/a) - 4.01%
#5	DIANTHUS THERAPEUTICS INC (DNTH) - 2.72%	ROCHE HOLDING AG ADR (RHHBY) - 3.76%
#6	TRAVERE THERAPEUTICS INC ORDINARY SHARES (TVTX) - 2.70%	MERCK & CO INC (MRK) - 3.39%
#7	ORUKA THERAPEUTICS INC (ORKA) - 2.65%	JOHNSON & JOHNSON (JNJ) - 3.34%
#8	n/a (DFTX) - 2.63%	LEGEND BIOTECH CORP ADR (LEGN) - 3.27%
#9	VERADERMICS INC (MANE) - 2.59%	BRISTOL-MYERS SQUIBB CO (BMY) - 3.25%
#10	EDGEWISE THERAPEUTICS INC (EWTX) - 2.59%	ABBVIE INC (ABBV) - 3.23%
#11	ACADIA PHARMACEUTICALS INC (ACAD) - 2.25%	IMMUNOME INC ORDINARY SHARES (IMNM) - 3.21%
#12	RELAY THERAPEUTICS INC ORDINARY SHARES (RLAY) - 2.25%	EXELIXIS INC (EXEL) - 2.86%
#13	DENALI THERAPEUTICS INC (DNLI) - 2.15%	ASTRAZENECA PLC (AZN:XLON) - 2.72%
#14	NEWAMSTERDAM PHARMA CO NV (NAMS) - 2.09%	IDEAYA BIOSCIENCES INC (IDYA) - 2.63%
#15	DYNE THERAPEUTICS INC ORDINARY SHARES (DYN) - 2.00%	CG ONCOLOGY INC (CGON) - 2.61%
#16	STRUCTURE THERAPEUTICS INC ADR (GPCR) - 1.95%	BRIDGEBIO PHARMA INC (BBIO) - 2.59%
#17	IDEAYA BIOSCIENCES INC (IDYA) - 1.63%	AMGEN INC (AMGN) - 2.53%
#18	MBX BIOSCIENCES INC (MBX) - 1.55%	GENMAB AS ADR (GMAB) - 2.42%
#19	VERA THERAPEUTICS INC CLASS A (VERA) - 1.52%	CELCUITY INC (CELC) - 2.40%
#20	CELLDEX THERAPEUTICS INC (CLDX) - 1.52%	FIRST AMERICAN TREASURY OBLIGS X (FXFXX) - 1.91%
#21	DISC MEDICINE INC ORDINARY SHARES (IRON) - 1.50%	ERASCA INC (ERAS) - 1.88%
#22	n/a (TARS) - 1.37%	BEONE MEDICINES LTD ADR (ONC) - 1.86%
#23	BIOCRYST PHARMACEUTICALS INC (BCRX) - 1.36%	RELAY THERAPEUTICS INC ORDINARY SHARES (RLAY) - 1.78%
#24	KAILERA THERAPEUTICS INC (KLRA) - 1.36%	HALOZYME THERAPEUTICS INC (HALO) - 1.68%
#25	IMMUNOME INC ORDINARY SHARES (IMNM) - 1.36%	ENLIVEN THERAPEUTICS INC (ELVN) - 1.66%
Total Holdings	107	60

SBIO vs CANC - Historical Returns

Returns include dividend reinvestment.

Period	SBIO	CANC
1 month	+10.77%	+8.03%
3 months	+16.31%	+4.16%
6 months	+22.65%	+11.29%
1 year	+99.16%	+58.11%
5 years(CAGR)	+7.32%	-7.41%
10 years(CAGR)	+11.27%	N/A
Max(CAGR)	+9.47%	-7.41%

Winner

SBIO

+10.77%

CANC

+8.03%

Winner

SBIO

+16.31%

CANC

+4.16%

Winner

SBIO

+22.65%

CANC

+11.29%

Winner

SBIO

+99.16%

CANC

+58.11%

5Y(CAGR)

Winner

SBIO

+7.32%

CANC

-7.41%

10Y(CAGR)

SBIO

+11.27%

CANC

N/A

Max(CAGR)

Winner

SBIO

+9.47%

CANC

-7.41%

SBIO vs CANC - Annual Returns (2014 - 2026)

Returns include dividend reinvestment.

Year	SBIO	CANC
2026	+29.55%	+18.95%
2025	+53.69%	+42.13%
2024	+4.25%	-6.11%
2023	+11.05%	+515.06%
2022	-30.19%	-85.58%
2021	-17.90%	-51.82%
2020	+23.09%	N/A
2019	+47.58%	N/A
2018	-13.24%	N/A
2017	+44.12%	N/A
2016	-25.20%	N/A
2015	+26.42%	N/A
2014	+0.00%	N/A

SBIO vs CANC Drawdown Comparison

The maximum drawdown for SBIO was -63.06%, occurring on Oct 27, 2023. Recovery took 1350 trading sessions.

The maximum drawdown for CANC was -97.53%, occurring on Apr 5, 2023. This drawdown has not yet recovered.

The current SBIO drawdown is -5.74%. The current CANC drawdown is -50.88%.

Rank	SBIO	CANC
#1	-63.06% Feb 8, 2021 - Jun 25, 2026	-97.53% Oct 20, 2021 - Apr 5, 2023
#2	-49.69% Jul 17, 2015 - Jun 6, 2018	-16.18% Oct 5, 2021 - Oct 20, 2021
#3	-39.30% Dec 24, 2019 - Jun 23, 2020	N/A
#4	-32.42% Sep 28, 2018 - Nov 25, 2019	N/A
#5	-13.78% Apr 23, 2015 - May 20, 2015	N/A
#6	-13.03% Jun 23, 2020 - Oct 7, 2020	N/A
#7	-11.31% Mar 19, 2015 - Apr 13, 2015	N/A
#8	-7.98% Jul 9, 2026 - Jul 16, 2026	N/A
#9	-6.72% Jun 6, 2018 - Sep 28, 2018	N/A
#10	-6.30% Jan 27, 2015 - Feb 17, 2015	N/A
#11	-6.29% Jun 22, 2015 - Jul 13, 2015	N/A
#12	-6.19% Dec 22, 2020 - Jan 7, 2021	N/A
#13	-4.88% Oct 13, 2020 - Oct 27, 2020	N/A
#14	-3.81% Jan 14, 2015 - Jan 20, 2015	N/A
#15	-3.39% Oct 27, 2020 - Nov 4, 2020	N/A