SBIO vs USEW
Comparison between ALPS MEDICAL BREAKTHROUGHS ETF (SBIO, ETF) and Cambria US EW ETF (USEW, ETF).
SBIO vs USEW - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Net Assets
Winner
SBIO
$190M
USEW
$190M
Expense Ratio
SBIO
0.50%
Winner
USEW
0.30%
Max Drawdown
SBIO
63.06%
Winner
USEW
8.25%
Sharpe Ratio
Winner
SBIO
2.26
USEW
1.18
5Y Beta
SBIO
1.01
Winner
USEW
0.88
P/E Ratio
SBIO
-5.74
USEW
N/A
5Y Dividends CAGR
SBIO
9.24%
USEW
N/A
Debt to Equity
SBIO
0.42%
USEW
N/A
P/S Ratio
SBIO
8.00
USEW
N/A
P/B Ratio
SBIO
4.14
USEW
N/A
SBIO vs USEW - Holdings Comparison
SBIO and USEW have 3 common holdings. Overlap is 0.02%
SBIO's top 25 holdings weight is 56.86%. USEW's top 25 holdings weight is 48.80%.
| Rank | SBIO | USEW |
|---|---|---|
| #1 | CRINETICS PHARMACEUTICALS INC (CRNX) - 4.38% | INVESCO S&P 500® LOW VOLATILITY ETF (SPLV) - 6.64% |
| #2 | APOGEE THERAPEUTICS INC (APGE) - 4.11% | STATE STREET® SPDR® S&P 500® ETF (SPY) - 4.04% |
| #3 | XENON PHARMACEUTICALS INC (XENE) - 3.41% | NVIDIA CORP (NVDA) - 3.44% |
| #4 | CG ONCOLOGY INC (CGON) - 3.22% | MICROSOFT CORP (MSFT) - 3.34% |
| #5 | DIANTHUS THERAPEUTICS INC (DNTH) - 2.72% | APPLE INC (AAPL) - 3.01% |
| #6 | TRAVERE THERAPEUTICS INC ORDINARY SHARES (TVTX) - 2.70% | INVESCO QQQ TRUST (QQQ) - 2.88% |
| #7 | ORUKA THERAPEUTICS INC (ORKA) - 2.65% | FIDELITY VALUE FACTOR ETF (FVAL) - 2.74% |
| #8 | n/a (DFTX) - 2.63% | VANGUARD S&P 500 ETF (VOO) - 2.46% |
| #9 | VERADERMICS INC (MANE) - 2.59% | ISHARES RUSSELL 1000 VALUE ETF (IWD) - 1.89% |
| #10 | EDGEWISE THERAPEUTICS INC (EWTX) - 2.59% | n/a (MDYV) - 1.86% |
| #11 | ACADIA PHARMACEUTICALS INC (ACAD) - 2.25% | INVESCO S&P 500® EQUAL WEIGHT ETF (RSP) - 1.83% |
| #12 | RELAY THERAPEUTICS INC ORDINARY SHARES (RLAY) - 2.25% | VANGUARD TOTAL STOCK MARKET ETF (VTI) - 1.68% |
| #13 | DENALI THERAPEUTICS INC (DNLI) - 2.15% | ALPHABET INC CLASS C (GOOG) - 1.67% |
| #14 | NEWAMSTERDAM PHARMA CO NV (NAMS) - 2.09% | INVESCO S&P GLOBAL WATER ETF (CGW) - 1.55% |
| #15 | DYNE THERAPEUTICS INC ORDINARY SHARES (DYN) - 2.00% | AMAZON.COM INC (AMZN) - 1.53% |
| #16 | STRUCTURE THERAPEUTICS INC ADR (GPCR) - 1.95% | META PLATFORMS INC CLASS A (META) - 1.46% |
| #17 | IDEAYA BIOSCIENCES INC (IDYA) - 1.63% | BERKSHIRE HATHAWAY INC CLASS B (BRK-B) - 1.46% |
| #18 | MBX BIOSCIENCES INC (MBX) - 1.55% | BROADCOM INC (AVGO) - 1.37% |
| #19 | VERA THERAPEUTICS INC CLASS A (VERA) - 1.52% | VANGUARD VALUE ETF (VTV) - 1.25% |
| #20 | CELLDEX THERAPEUTICS INC (CLDX) - 1.52% | PROSHARES S&P 500 DIVIDEND ARISTOCRATS (NOBL) - 1.12% |
| #21 | DISC MEDICINE INC ORDINARY SHARES (IRON) - 1.50% | n/a (SHOP) - 0.33% |
| #22 | n/a (TARS) - 1.37% | ISHARES CORE S&P MID-CAP ETF (IJH) - 0.32% |
| #23 | BIOCRYST PHARMACEUTICALS INC (BCRX) - 1.36% | ISHARES MSCI USA MOMENTUM FACTOR ETF (MTUM) - 0.32% |
| #24 | KAILERA THERAPEUTICS INC (KLRA) - 1.36% | ISHARES MSCI USA MIN VOL FACTOR ETF (USMV) - 0.31% |
| #25 | IMMUNOME INC ORDINARY SHARES (IMNM) - 1.36% | AMERICAN EXPRESS CO (AXP) - 0.30% |
| Total Holdings | 107 | 557 |
SBIO vs USEW - Historical Returns
Returns include dividend reinvestment.
1M
Winner
SBIO
+10.77%
USEW
+0.17%
3M
Winner
SBIO
+16.31%
USEW
+6.10%
6M
Winner
SBIO
+22.65%
USEW
+8.53%
1Y
SBIO
+99.16%
USEW
N/A
5Y(CAGR)
SBIO
+7.32%
USEW
N/A
10Y(CAGR)
SBIO
+11.27%
USEW
N/A
Max(CAGR)
SBIO
+9.47%
Winner
USEW
+18.92%
SBIO vs USEW - Annual Returns (2014 - 2026)
Returns include dividend reinvestment.
| Year | SBIO | USEW |
|---|---|---|
| 2026 | +29.55% | +9.76% |
| 2025 | +53.69% | +0.77% |
| 2024 | +4.25% | N/A |
| 2023 | +11.05% | N/A |
| 2022 | -30.19% | N/A |
| 2021 | -17.90% | N/A |
| 2020 | +23.09% | N/A |
| 2019 | +47.58% | N/A |
| 2018 | -13.24% | N/A |
| 2017 | +44.12% | N/A |
| 2016 | -25.20% | N/A |
| 2015 | +26.42% | N/A |
| 2014 | +0.00% | N/A |
SBIO vs USEW Drawdown Comparison
The maximum drawdown for SBIO was -63.06%, occurring on Oct 27, 2023. Recovery took 1350 trading sessions.
The maximum drawdown for USEW was -7.85%, occurring on Mar 30, 2026. Recovery took 54 trading sessions.
The current SBIO drawdown is -5.74%. The current USEW drawdown is -1.01%.
| Rank | SBIO | USEW |
|---|---|---|
| #1 | -63.06% Feb 8, 2021 - Jun 25, 2026 | -7.85% Jan 27, 2026 - Apr 15, 2026 |
| #2 | -49.69% Jul 17, 2015 - Jun 6, 2018 | -3.00% Jun 4, 2026 - Jun 15, 2026 |
| #3 | -39.30% Dec 24, 2019 - Jun 23, 2020 | -2.03% Jan 12, 2026 - Jan 27, 2026 |
| #4 | -32.42% Sep 28, 2018 - Nov 25, 2019 | -1.83% Jul 10, 2026 - Jul 20, 2026 |
| #5 | -13.78% Apr 23, 2015 - May 20, 2015 | -1.62% May 14, 2026 - May 22, 2026 |
| #6 | -13.03% Jun 23, 2020 - Oct 7, 2020 | -1.45% Jun 15, 2026 - Jun 30, 2026 |
| #7 | -11.31% Mar 19, 2015 - Apr 13, 2015 | -1.25% Dec 24, 2025 - Jan 6, 2026 |
| #8 | -7.98% Jul 9, 2026 - Jul 16, 2026 | -1.02% Jul 6, 2026 - Jul 10, 2026 |
| #9 | -6.72% Jun 6, 2018 - Sep 28, 2018 | -0.79% May 6, 2026 - May 14, 2026 |
| #10 | -6.30% Jan 27, 2015 - Feb 17, 2015 | -0.67% Jan 6, 2026 - Jan 9, 2026 |
| #11 | -6.29% Jun 22, 2015 - Jul 13, 2015 | -0.63% Apr 17, 2026 - Apr 30, 2026 |
| #12 | -6.19% Dec 22, 2020 - Jan 7, 2021 | -0.48% May 1, 2026 - May 5, 2026 |
| #13 | -4.88% Oct 13, 2020 - Oct 27, 2020 | -0.42% Jun 2, 2026 - Jun 4, 2026 |
| #14 | -3.81% Jan 14, 2015 - Jan 20, 2015 | -0.21% Jun 30, 2026 - Jul 6, 2026 |
| #15 | -3.39% Oct 27, 2020 - Nov 4, 2020 | -0.11% May 26, 2026 - May 28, 2026 |
Correlation
Correlation between SBIO and USEW is 0.80 which considered as a strong positive correlation - the stocks tend to move together.
0.80
-101
Dividend Comparison (2017 - 2026)
SBIO vs USEW dividend yield comparison.
| Year | SBIO | USEW |
|---|---|---|
| 2026 | 0.00% | 0.44% |
| 2025 | 0.00% | 0.13% |
| 2024 | 3.55% | 0.00% |
| 2023 | 0.22% | 0.00% |
| 2019 | 0.04% | 0.00% |
| 2018 | 2.79% | 0.00% |
| 2017 | 1.77% | 0.00% |
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