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CANC vs SPY

Comparison between TEMA ONCOLOGY ETF (CANC, ETF) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed CANC, delivering a return of +13.0% compared to -7.4%

CANC vs SPY - Performance Comparison

Key Characteristics

Financial metrics and valuation ratios

Net Assets
CANC
$190M
Winner
SPY
$781B
Expense Ratio
CANC
0.75%
Winner
SPY
0.09%
Max Drawdown
CANC
97.53%
Winner
SPY
56.47%
Sharpe Ratio
Winner
CANC
1.94
SPY
1.25
5Y Beta
Winner
CANC
0.74
SPY
1.00
P/E Ratio
Winner
CANC
-28.60
SPY
28.78
Forward P/E
CANC
N/A
SPY
21.23
5Y Dividends CAGR
CANC
N/A
SPY
6.00%
5Y EPS CAGR
CANC
10.35%
Winner
SPY
25.62%
Debt to Equity
CANC
66.51%
Winner
SPY
31.92%
P/S Ratio
CANC
8.97
Winner
SPY
3.76
P/B Ratio
CANC
7.20
Winner
SPY
5.64

CANC vs SPY - Holdings Comparison

CANC and SPY have 9 common holdings. Overlap is 4.18%

CANC's top 25 holdings weight is 74.89%. SPY's top 25 holdings weight is 51.74%.

RankCANCSPY
#1
REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 6.05%
NVIDIA CORP (NVDA) - 7.89%
#2
ELI LILLY AND CO (LLY) - 4.93%
APPLE INC (AAPL) - 7.37%
#3
COGENT BIOSCIENCES INC (COGT) - 4.92%
MICROSOFT CORP (MSFT) - 4.50%
#4
NOVARTIS AG REGISTERED SHARES (n/a) - 4.01%
AMAZON.COM INC (AMZN) - 3.82%
#5
ROCHE HOLDING AG ADR (RHHBY) - 3.76%
ALPHABET INC CLASS A (GOOGL) - 3.33%
#6
MERCK & CO INC (MRK) - 3.39%
BROADCOM INC (AVGO) - 2.86%
#7
JOHNSON & JOHNSON (JNJ) - 3.34%
ALPHABET INC CLASS C (GOOG) - 2.68%
#8
LEGEND BIOTECH CORP ADR (LEGN) - 3.27%
META PLATFORMS INC CLASS A (META) - 2.29%
#9
BRISTOL-MYERS SQUIBB CO (BMY) - 3.25%
TESLA INC (TSLA) - 1.70%
#10
ABBVIE INC (ABBV) - 3.23%
MICRON TECHNOLOGY INC (MU) - 1.56%
#11
IMMUNOME INC ORDINARY SHARES (IMNM) - 3.21%
JPMORGAN CHASE & CO (JPM) - 1.42%
#12
EXELIXIS INC (EXEL) - 2.86%
ELI LILLY AND CO (LLY) - 1.40%
#13
ASTRAZENECA PLC (AZN:XLON) - 2.72%
BERKSHIRE HATHAWAY INC CLASS B (BRK-B) - 1.37%
#14
IDEAYA BIOSCIENCES INC (IDYA) - 2.63%
ADVANCED MICRO DEVICES INC (AMD) - 1.32%
#15
CG ONCOLOGY INC (CGON) - 2.61%
EXXONMOBIL HOLDINGS CORP (XOM) - 0.92%
#16
BRIDGEBIO PHARMA INC (BBIO) - 2.59%
JOHNSON & JOHNSON (JNJ) - 0.91%
#17
AMGEN INC (AMGN) - 2.53%
VISA INC CLASS A (V) - 0.90%
#18
GENMAB AS ADR (GMAB) - 2.42%
WALMART INC (WMT) - 0.76%
#19
CELCUITY INC (CELC) - 2.40%
INTEL CORP (INTC) - 0.75%
#20
FIRST AMERICAN TREASURY OBLIGS X (FXFXX) - 1.91%
APPLIED MATERIALS INC (AMAT) - 0.70%
#21
ERASCA INC (ERAS) - 1.88%
CISCO SYSTEMS INC (CSCO) - 0.68%
#22
BEONE MEDICINES LTD ADR (ONC) - 1.86%
MASTERCARD INC CLASS A (MA) - 0.66%
#23
RELAY THERAPEUTICS INC ORDINARY SHARES (RLAY) - 1.78%
ABBVIE INC (ABBV) - 0.66%
#24
HALOZYME THERAPEUTICS INC (HALO) - 1.68%
CATERPILLAR INC (CAT) - 0.65%
#25
ENLIVEN THERAPEUTICS INC (ELVN) - 1.66%
LAM RESEARCH CORP (LRCX) - 0.64%
Total Holdings60505

CANC vs SPY - Historical Returns

Returns include dividend reinvestment.

1M
Winner
CANC
+8.03%
SPY
+0.52%
3M
CANC
+4.16%
Winner
SPY
+6.55%
6M
Winner
CANC
+11.29%
SPY
+9.76%
1Y
Winner
CANC
+58.11%
SPY
+20.32%
5Y(CAGR)
CANC
-7.41%
Winner
SPY
+13.01%
10Y(CAGR)
CANC
N/A
SPY
+15.06%
Max(CAGR)
CANC
-7.41%
Winner
SPY
+8.50%

CANC vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

YearCANCSPY
2026+18.95%+10.11%
2025+42.13%+18.00%
2024-6.11%+25.59%
2023+515.06%+26.72%
2022-85.58%-18.64%
2021-51.82%+30.52%
2020N/A+17.28%
2019N/A+31.09%
2018N/A-5.24%
2017N/A+20.78%
2016N/A+13.59%
2015N/A+1.31%
2014N/A+14.56%
2013N/A+29.00%
2012N/A+14.17%
2011N/A+0.85%
2010N/A+13.14%
2009N/A+22.67%
2008N/A-36.25%
2007N/A+5.32%
2006N/A+13.85%
2005N/A+5.32%
2004N/A+10.75%
2003N/A+24.18%
2002N/A-22.42%
2001N/A-10.13%
2000N/A-8.84%
1999N/A+8.61%

CANC vs SPY Drawdown Comparison

The maximum drawdown for CANC was -97.53%, occurring on Apr 5, 2023. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current CANC drawdown is -50.88%. The current SPY drawdown is -1.24%.

RankCANCSPY
#1-97.53%
Oct 20, 2021 - Apr 5, 2023		-55.20%
Oct 9, 2007 - Aug 16, 2012
#2-16.18%
Oct 5, 2021 - Oct 20, 2021		-47.50%
Mar 24, 2000 - Oct 26, 2006
#3N/A-33.70%
Feb 19, 2020 - Aug 10, 2020
#4N/A-24.50%
Jan 3, 2022 - Dec 13, 2023
#5N/A-19.34%
Sep 20, 2018 - Apr 12, 2019
#6N/A-18.76%
Feb 19, 2025 - Jun 26, 2025
#7N/A-13.02%
Jul 20, 2015 - Apr 18, 2016
#8N/A-10.10%
Jan 26, 2018 - Aug 6, 2018
#9N/A-9.44%
Sep 2, 2020 - Nov 11, 2020
#10N/A-9.30%
Jan 19, 2000 - Mar 17, 2000
#11N/A-9.05%
Jul 19, 2007 - Oct 5, 2007
#12N/A-8.88%
Jan 27, 2026 - Apr 14, 2026
#13N/A-8.41%
Jul 16, 2024 - Sep 19, 2024
#14N/A-7.35%
Sep 14, 2012 - Jan 2, 2013
#15N/A-7.27%
Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between CANC and SPY is 0.63 which considered as a moderate positive correlation - the stocks show some tendency to move together.

0.63
-101

Dividend Comparison (1999 - 2026)

CANC vs SPY dividend yield comparison.

YearCANCSPY
20260.00%0.49%
20250.06%1.07%
20243.00%1.21%
20230.56%1.40%
20220.00%1.65%
20210.00%1.20%
20200.00%1.52%
20190.00%1.75%
20180.00%2.04%
20170.00%1.80%
20160.00%2.03%
20150.00%2.06%
20140.00%1.87%
20130.00%1.81%
20120.00%2.18%
20110.00%2.05%
20100.00%1.80%
20090.00%1.95%
20080.00%3.02%
20070.00%1.85%
20060.00%1.73%
20050.00%1.73%
20040.00%1.82%
20030.00%1.47%
20020.00%1.70%
20010.00%1.25%
20000.00%1.15%
19990.00%0.24%

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