CANC vs USEW

Comparison between TEMA ONCOLOGY ETF (CANC, ETF) and Cambria US EW ETF (USEW, ETF).

CANC vs USEW - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	CANC(ETF)	USEW(ETF)
Net Assets	$190M	$190M
Expense Ratio	0.75%	0.30%
Max Drawdown	97.53%	8.25%
Sharpe Ratio	1.94	1.18
5Y Beta	0.74	0.88
P/E Ratio	-28.60	N/A
5Y EPS CAGR	10.35%	N/A
Debt to Equity	66.51%	N/A
P/S Ratio	8.97	N/A
P/B Ratio	7.20	N/A

Net Assets

CANC

$190M

Winner

USEW

$190M

Expense Ratio

CANC

0.75%

Winner

USEW

0.30%

Max Drawdown

CANC

97.53%

Winner

USEW

8.25%

Sharpe Ratio

Winner

CANC

1.94

USEW

1.18

5Y Beta

Winner

CANC

0.74

USEW

0.88

P/E Ratio

CANC

-28.60

USEW

N/A

5Y EPS CAGR

CANC

10.35%

USEW

N/A

Debt to Equity

CANC

66.51%

USEW

N/A

P/S Ratio

CANC

8.97

USEW

N/A

P/B Ratio

CANC

7.20

USEW

N/A

CANC vs USEW - Holdings Comparison

CANC and USEW have 11 common holdings. Overlap is 0.93%

CANC's top 25 holdings weight is 74.89%. USEW's top 25 holdings weight is 48.80%.

Rank	CANC	USEW
#1	REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 6.05%	INVESCO S&P 500® LOW VOLATILITY ETF (SPLV) - 6.64%
#2	ELI LILLY AND CO (LLY) - 4.93%	STATE STREET® SPDR® S&P 500® ETF (SPY) - 4.04%
#3	COGENT BIOSCIENCES INC (COGT) - 4.92%	NVIDIA CORP (NVDA) - 3.44%
#4	NOVARTIS AG REGISTERED SHARES (n/a) - 4.01%	MICROSOFT CORP (MSFT) - 3.34%
#5	ROCHE HOLDING AG ADR (RHHBY) - 3.76%	APPLE INC (AAPL) - 3.01%
#6	MERCK & CO INC (MRK) - 3.39%	INVESCO QQQ TRUST (QQQ) - 2.88%
#7	JOHNSON & JOHNSON (JNJ) - 3.34%	FIDELITY VALUE FACTOR ETF (FVAL) - 2.74%
#8	LEGEND BIOTECH CORP ADR (LEGN) - 3.27%	VANGUARD S&P 500 ETF (VOO) - 2.46%
#9	BRISTOL-MYERS SQUIBB CO (BMY) - 3.25%	ISHARES RUSSELL 1000 VALUE ETF (IWD) - 1.89%
#10	ABBVIE INC (ABBV) - 3.23%	n/a (MDYV) - 1.86%
#11	IMMUNOME INC ORDINARY SHARES (IMNM) - 3.21%	INVESCO S&P 500® EQUAL WEIGHT ETF (RSP) - 1.83%
#12	EXELIXIS INC (EXEL) - 2.86%	VANGUARD TOTAL STOCK MARKET ETF (VTI) - 1.68%
#13	ASTRAZENECA PLC (AZN:XLON) - 2.72%	ALPHABET INC CLASS C (GOOG) - 1.67%
#14	IDEAYA BIOSCIENCES INC (IDYA) - 2.63%	INVESCO S&P GLOBAL WATER ETF (CGW) - 1.55%
#15	CG ONCOLOGY INC (CGON) - 2.61%	AMAZON.COM INC (AMZN) - 1.53%
#16	BRIDGEBIO PHARMA INC (BBIO) - 2.59%	META PLATFORMS INC CLASS A (META) - 1.46%
#17	AMGEN INC (AMGN) - 2.53%	BERKSHIRE HATHAWAY INC CLASS B (BRK-B) - 1.46%
#18	GENMAB AS ADR (GMAB) - 2.42%	BROADCOM INC (AVGO) - 1.37%
#19	CELCUITY INC (CELC) - 2.40%	VANGUARD VALUE ETF (VTV) - 1.25%
#20	FIRST AMERICAN TREASURY OBLIGS X (FXFXX) - 1.91%	PROSHARES S&P 500 DIVIDEND ARISTOCRATS (NOBL) - 1.12%
#21	ERASCA INC (ERAS) - 1.88%	n/a (SHOP) - 0.33%
#22	BEONE MEDICINES LTD ADR (ONC) - 1.86%	ISHARES CORE S&P MID-CAP ETF (IJH) - 0.32%
#23	RELAY THERAPEUTICS INC ORDINARY SHARES (RLAY) - 1.78%	ISHARES MSCI USA MOMENTUM FACTOR ETF (MTUM) - 0.32%
#24	HALOZYME THERAPEUTICS INC (HALO) - 1.68%	ISHARES MSCI USA MIN VOL FACTOR ETF (USMV) - 0.31%
#25	ENLIVEN THERAPEUTICS INC (ELVN) - 1.66%	AMERICAN EXPRESS CO (AXP) - 0.30%
Total Holdings	60	557

CANC vs USEW - Historical Returns

Returns include dividend reinvestment.

Period	CANC	USEW
1 month	+8.03%	+0.17%
3 months	+4.16%	+6.10%
6 months	+11.29%	+8.53%
1 year	+58.11%	N/A
5 years(CAGR)	-7.41%	N/A
Max(CAGR)	-7.41%	+18.92%

Winner

CANC

+8.03%

USEW

+0.17%

CANC

+4.16%

Winner

USEW

+6.10%

Winner

CANC

+11.29%

USEW

+8.53%

CANC

+58.11%

USEW

N/A

5Y(CAGR)

CANC

-7.41%

USEW

N/A

Max(CAGR)

CANC

-7.41%

Winner

USEW

+18.92%

CANC vs USEW - Annual Returns (2021 - 2026)

Returns include dividend reinvestment.

Year	CANC	USEW
2026	+18.95%	+9.76%
2025	+42.13%	+0.77%
2024	-6.11%	N/A
2023	+515.06%	N/A
2022	-85.58%	N/A
2021	-51.82%	N/A

CANC vs USEW Drawdown Comparison

The maximum drawdown for CANC was -97.53%, occurring on Apr 5, 2023. This drawdown has not yet recovered.

The maximum drawdown for USEW was -7.85%, occurring on Mar 30, 2026. Recovery took 54 trading sessions.

The current CANC drawdown is -50.88%. The current USEW drawdown is -1.01%.

Rank	CANC	USEW
#1	-97.53% Oct 20, 2021 - Apr 5, 2023	-7.85% Jan 27, 2026 - Apr 15, 2026
#2	-16.18% Oct 5, 2021 - Oct 20, 2021	-3.00% Jun 4, 2026 - Jun 15, 2026
#3	N/A	-2.03% Jan 12, 2026 - Jan 27, 2026
#4	N/A	-1.83% Jul 10, 2026 - Jul 20, 2026
#5	N/A	-1.62% May 14, 2026 - May 22, 2026
#6	N/A	-1.45% Jun 15, 2026 - Jun 30, 2026
#7	N/A	-1.25% Dec 24, 2025 - Jan 6, 2026
#8	N/A	-1.02% Jul 6, 2026 - Jul 10, 2026
#9	N/A	-0.79% May 6, 2026 - May 14, 2026
#10	N/A	-0.67% Jan 6, 2026 - Jan 9, 2026
#11	N/A	-0.63% Apr 17, 2026 - Apr 30, 2026
#12	N/A	-0.48% May 1, 2026 - May 5, 2026
#13	N/A	-0.42% Jun 2, 2026 - Jun 4, 2026
#14	N/A	-0.21% Jun 30, 2026 - Jul 6, 2026
#15	N/A	-0.11% May 26, 2026 - May 28, 2026