PTGX vs CRNX

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Crinetics Pharmaceuticals Inc (CRNX, Company).

Both PTGX and CRNX are from the Healthcare sector.

5-Year PerformanceCRNX has outperformed PTGX, delivering a return of +36.7% compared to +24.8%

PTGX vs CRNX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	CRNX(COMPANY)
Market Cap	$8.88B	$8.89B
Max Drawdown	85.79%	68.70%
Sharpe Ratio	2.09	1.32
5Y Beta	0.24	0.98
Industry	Biotechnology	Biotechnology
P/E Ratio	110.94	-16.74
Forward P/E	30.96	N/A
PEG Ratio	2.44	-0.73
5Y EPS CAGR	N/A	14.06%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	1.47%	-4.78%
P/S Ratio	117.93	211.41
P/B Ratio	13.40	6.90

Market Cap

PTGX

$8.88B

Winner

CRNX

$8.89B

Max Drawdown

PTGX

85.79%

Winner

CRNX

68.70%

Sharpe Ratio

Winner

PTGX

2.09

CRNX

1.32

5Y Beta

Winner

PTGX

0.24

CRNX

0.98

Industry

PTGX

Biotechnology

CRNX

Biotechnology

P/E Ratio

PTGX

110.94

Winner

CRNX

-16.74

Forward P/E

PTGX

30.96

CRNX

N/A

PEG Ratio

PTGX

2.44

Winner

CRNX

-0.73

5Y EPS CAGR

PTGX

N/A

CRNX

14.06%

Debt to Equity

PTGX

0.00%

CRNX

0.00%

Free Cash Flow Yield

Winner

PTGX

1.47%

CRNX

-4.78%

P/S Ratio

Winner

PTGX

117.93

CRNX

211.41

P/B Ratio

PTGX

13.40

Winner

CRNX

6.90

PTGX vs CRNX - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	CRNX
1 month	+3.56%	+0.66%
3 months	+47.57%	+93.33%
6 months	+72.65%	+85.69%
1 year	+186.24%	+201.58%
5 years(CAGR)	+24.83%	+36.70%
10 years(CAGR)	+28.74%	+16.54%
Max(CAGR)	+28.74%	+16.54%

Winner

PTGX

+3.56%

CRNX

+0.66%

PTGX

+47.57%

Winner

CRNX

+93.33%

PTGX

+72.65%

Winner

CRNX

+85.69%

PTGX

+186.24%

Winner

CRNX

+201.58%

5Y(CAGR)

PTGX

+24.83%

Winner

CRNX

+36.70%

10Y(CAGR)

Winner

PTGX

+28.74%

CRNX

+16.54%

Max(CAGR)

Winner

PTGX

+28.74%

CRNX

+16.54%

PTGX vs CRNX - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	PTGX	CRNX
2026	+67.32%	+79.93%
2025	+124.06%	-9.70%
2024	+64.82%	+44.48%
2023	+112.71%	+96.57%
2022	-69.11%	-35.36%
2021	+74.49%	+103.66%
2020	+190.91%	-44.45%
2019	+2.32%	-14.40%
2018	-68.18%	+22.36%
2017	-1.79%	N/A
2016	+87.95%	N/A

PTGX vs CRNX Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for CRNX was -68.70%, occurring on Mar 16, 2020. Recovery took 1326 trading sessions.

The current PTGX drawdown is -0.21%.

Rank	PTGX	CRNX
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-68.70% Sep 12, 2018 - Dec 19, 2023
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-57.88% Nov 8, 2024 - Jul 7, 2026
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-18.72% May 16, 2024 - Jul 11, 2024
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-17.60% Mar 1, 2024 - Mar 28, 2024
#5	-19.04% Mar 19, 2021 - May 18, 2021	-13.35% Jul 16, 2024 - Oct 15, 2024
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-12.30% Apr 11, 2024 - May 8, 2024
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-9.31% Aug 23, 2018 - Sep 6, 2018
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-8.79% Feb 9, 2024 - Feb 27, 2024
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-7.55% Jul 18, 2018 - Jul 23, 2018
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-6.96% Dec 19, 2023 - Jan 9, 2024
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	-6.46% Oct 22, 2024 - Nov 7, 2024
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	-6.38% Jan 9, 2024 - Feb 8, 2024
#13	-7.78% Jul 7, 2026 - Jul 17, 2026	-5.82% May 8, 2024 - May 16, 2024
#14	-7.43% Mar 31, 2026 - Apr 15, 2026	-4.49% Aug 13, 2018 - Aug 17, 2018
#15	-7.20% Jun 14, 2021 - Jun 16, 2021	-4.26% Feb 28, 2024 - Mar 1, 2024