PTGX vs SPY
Comparison between Protagonist Therapeutics Inc (PTGX, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).
5-Year PerformancePTGX has outperformed SPY, delivering a return of +27.4% compared to +13.7%
PTGX vs SPY - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap / Net Assets
PTGX
$6.67B
Winner
SPY
$735B
Expense Ratio
PTGX
N/A
SPY
0.09%
Max Drawdown
PTGX
85.79%
Winner
SPY
56.47%
Sharpe Ratio
Winner
PTGX
1.87
SPY
1.76
5Y Beta
Winner
PTGX
0.26
SPY
1.00
Industry
PTGX
Biotechnology
SPY
N/A
P/E Ratio
Winner
PTGX
-56.45
SPY
28.46
Forward P/E
PTGX
23.75
Winner
SPY
21.99
PEG Ratio
PTGX
0.00
SPY
N/A
5Y Dividends CAGR
PTGX
N/A
SPY
5.43%
5Y EPS CAGR
PTGX
1.43%
Winner
SPY
25.20%
Debt to Equity
Winner
PTGX
0.00%
SPY
33.33%
Free Cash Flow Yield
PTGX
-1.77%
SPY
N/A
P/S Ratio
PTGX
90.08
Winner
SPY
3.65
P/B Ratio
PTGX
9.75
Winner
SPY
5.50
PTGX vs SPY - Historical Returns
Returns include dividend reinvestment.
1M
PTGX
-3.09%
Winner
SPY
+5.60%
3M
Winner
PTGX
+25.39%
SPY
+8.72%
6M
Winner
PTGX
+20.77%
SPY
+10.63%
1Y
Winner
PTGX
+130.08%
SPY
+26.62%
5Y(CAGR)
Winner
PTGX
+27.37%
SPY
+13.70%
10Y(CAGR)
Winner
PTGX
+24.87%
SPY
+15.47%
Max(CAGR)
Winner
PTGX
+24.87%
SPY
+8.50%
PTGX vs SPY - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | PTGX | SPY |
|---|---|---|
| 2026 | +17.21% | +8.50% |
| 2025 | +124.06% | +18.00% |
| 2024 | +64.82% | +25.59% |
| 2023 | +112.71% | +26.72% |
| 2022 | -69.11% | -18.64% |
| 2021 | +74.49% | +30.52% |
| 2020 | +190.91% | +17.28% |
| 2019 | +2.32% | +31.09% |
| 2018 | -68.18% | -5.24% |
| 2017 | -1.79% | +20.78% |
| 2016 | +87.95% | +13.59% |
| 2015 | N/A | +1.31% |
| 2014 | N/A | +14.56% |
| 2013 | N/A | +29.00% |
| 2012 | N/A | +14.17% |
| 2011 | N/A | +0.85% |
| 2010 | N/A | +13.14% |
| 2009 | N/A | +22.67% |
| 2008 | N/A | -36.25% |
| 2007 | N/A | +5.32% |
| 2006 | N/A | +13.85% |
| 2005 | N/A | +5.32% |
| 2004 | N/A | +10.75% |
| 2003 | N/A | +24.18% |
| 2002 | N/A | -22.42% |
| 2001 | N/A | -10.13% |
| 2000 | N/A | -8.84% |
| 1999 | N/A | +8.61% |
PTGX vs SPY Drawdown Comparison
The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.
The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.
The current PTGX drawdown is -3.59%. The current SPY drawdown is -1.20%.
| Rank | PTGX | SPY |
|---|---|---|
| #1 | -85.79% Sep 1, 2021 - Mar 10, 2025 | -55.20% Oct 9, 2007 - Aug 16, 2012 |
| #2 | -82.13% Dec 5, 2016 - Feb 16, 2021 | -47.50% Mar 24, 2000 - Oct 26, 2006 |
| #3 | -31.58% Mar 11, 2025 - Aug 27, 2025 | -33.70% Feb 19, 2020 - Aug 10, 2020 |
| #4 | -20.33% Oct 17, 2016 - Nov 10, 2016 | -24.50% Jan 3, 2022 - Dec 13, 2023 |
| #5 | -19.04% Mar 19, 2021 - May 18, 2021 | -19.34% Sep 20, 2018 - Apr 12, 2019 |
| #6 | -16.38% Dec 12, 2025 - Mar 9, 2026 | -18.76% Feb 19, 2025 - Jun 26, 2025 |
| #7 | -15.52% Oct 10, 2025 - Nov 24, 2025 | -13.02% Jul 20, 2015 - Apr 18, 2016 |
| #8 | -12.77% Feb 16, 2021 - Mar 2, 2021 | -10.10% Jan 26, 2018 - Aug 6, 2018 |
| #9 | -11.53% Aug 19, 2016 - Aug 31, 2016 | -9.44% Sep 2, 2020 - Nov 11, 2020 |
| #10 | -9.62% Jun 8, 2021 - Jun 11, 2021 | -9.30% Jan 19, 2000 - Mar 17, 2000 |
| #11 | -8.53% Aug 27, 2025 - Sep 18, 2025 | -9.05% Jul 19, 2007 - Oct 5, 2007 |
| #12 | -7.43% Mar 31, 2026 - Apr 15, 2026 | -8.88% Jan 27, 2026 - Apr 14, 2026 |
| #13 | -7.20% Jun 14, 2021 - Jun 16, 2021 | -8.41% Jul 16, 2024 - Sep 19, 2024 |
| #14 | -7.18% Apr 17, 2026 - May 1, 2026 | -7.35% Sep 14, 2012 - Jan 2, 2013 |
| #15 | -6.02% Nov 26, 2025 - Dec 8, 2025 | -7.27% Sep 18, 2014 - Oct 31, 2014 |
Correlation
Correlation between PTGX and SPY is 0.84 which considered as a strong positive correlation - the stocks tend to move together.
0.84
-101
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