PTGX vs KRYS

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Krystal Biotech Inc (KRYS, Company).

Both PTGX and KRYS are from the Healthcare sector.

5-Year PerformanceKRYS has outperformed PTGX, delivering a return of +43.6% compared to +27.5%

PTGX vs KRYS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	KRYS(COMPANY)
Market Cap	$9.83B	$9.85B
Max Drawdown	85.79%	53.42%
Sharpe Ratio	2.17	2.14
5Y Beta	N/A	0.85
Industry	Biotechnology	Biotechnology
P/E Ratio	122.81	40.35
Forward P/E	38.76	43.67
PEG Ratio	2.71	0.65
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	1.33%	2.62%
P/S Ratio	35.59	22.33
P/B Ratio	11.53	7.15

Market Cap

PTGX

$9.83B

Winner

KRYS

$9.85B

Max Drawdown

PTGX

85.79%

Winner

KRYS

53.42%

Sharpe Ratio

Winner

PTGX

2.17

KRYS

2.14

5Y Beta

PTGX

N/A

KRYS

0.85

Industry

PTGX

Biotechnology

KRYS

Biotechnology

P/E Ratio

PTGX

122.81

Winner

KRYS

40.35

Forward P/E

Winner

PTGX

38.76

KRYS

43.67

PEG Ratio

PTGX

2.71

Winner

KRYS

0.65

Debt to Equity

PTGX

0.00%

KRYS

0.00%

Free Cash Flow Yield

PTGX

1.33%

Winner

KRYS

2.62%

P/S Ratio

PTGX

35.59

Winner

KRYS

22.33

P/B Ratio

PTGX

11.53

Winner

KRYS

7.15

PTGX vs KRYS - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	KRYS
1 month	+11.66%	-6.21%
3 months	+56.18%	+14.08%
6 months	+89.59%	+17.48%
1 year	+179.91%	+127.49%
5 years(CAGR)	+27.52%	+43.57%
10 years(CAGR)	+29.74%	+47.18%
Max(CAGR)	+29.62%	+47.18%

Winner

PTGX

+11.66%

KRYS

-6.21%

Winner

PTGX

+56.18%

KRYS

+14.08%

Winner

PTGX

+89.59%

KRYS

+17.48%

Winner

PTGX

+179.91%

KRYS

+127.49%

5Y(CAGR)

PTGX

+27.52%

Winner

KRYS

+43.57%

10Y(CAGR)

PTGX

+29.74%

Winner

KRYS

+47.18%

Max(CAGR)

PTGX

+29.62%

Winner

KRYS

+47.18%

PTGX vs KRYS - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	PTGX	KRYS
2026	+80.48%	+34.79%
2025	+124.06%	+57.53%
2024	+64.82%	+25.37%
2023	+112.71%	+56.58%
2022	-69.11%	+9.86%
2021	+74.49%	+17.72%
2020	+190.91%	+5.28%
2019	+2.32%	+142.47%
2018	-68.18%	+126.36%
2017	-1.79%	-1.13%
2016	+87.95%	N/A

PTGX vs KRYS Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for KRYS was -53.42%, occurring on Nov 26, 2021. Recovery took 190 trading sessions.

The current PTGX drawdown is -0.81%. The current KRYS drawdown is -11.99%.

Rank	PTGX	KRYS
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-53.42% Mar 1, 2021 - Nov 29, 2021
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-46.65% Feb 12, 2020 - Jan 8, 2021
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-44.55% Nov 29, 2021 - Apr 13, 2023
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-42.26% Jul 26, 2024 - Nov 24, 2025
#5	-19.04% Mar 19, 2021 - May 18, 2021	-35.34% Jul 22, 2019 - Nov 13, 2019
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-28.43% Sep 11, 2018 - Oct 16, 2018
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-27.86% Dec 13, 2019 - Feb 12, 2020
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-26.81% Oct 18, 2017 - Mar 16, 2018
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-26.58% Jan 8, 2019 - Mar 25, 2019
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-26.34% Jun 13, 2023 - Jan 22, 2024
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	-24.99% May 14, 2019 - Jun 24, 2019
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	-24.14% Oct 16, 2018 - Nov 30, 2018
#13	-7.78% Jul 7, 2026 - Jul 17, 2026	-23.42% Mar 16, 2018 - Jun 6, 2018
#14	-7.43% Mar 31, 2026 - Apr 15, 2026	-19.86% Nov 30, 2018 - Jan 7, 2019
#15	-7.20% Jun 14, 2021 - Jun 16, 2021	-17.56% Jan 22, 2024 - Feb 26, 2024