PTGX vs AGNCM

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and AGNC Investment Corp (AGNCM, Company).

PTGX is from the Healthcare sector, while AGNCM is from the Real Estate sector.

5-Year PerformancePTGX has outperformed AGNCM, delivering a return of +24.8% compared to +7.6%

PTGX vs AGNCM - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	AGNCM(COMPANY)
Market Cap	$8.88B	$8.87B
Max Drawdown	85.79%	56.16%
Sharpe Ratio	2.09	0.93
5Y Beta	0.24	0.12
Industry	Biotechnology	Reit - Mortgage
P/E Ratio	110.94	30.46
Forward P/E	30.96	N/A
PEG Ratio	2.44	N/A
Dividend Yield	N/A	5.73%
5Y Dividends CAGR	N/A	9.54%
Debt to Equity	0.00%	N/A
Free Cash Flow Yield	1.47%	N/A
P/S Ratio	117.93	4.94
P/B Ratio	13.40	2.30

Market Cap

Winner

PTGX

$8.88B

AGNCM

$8.87B

Max Drawdown

PTGX

85.79%

Winner

AGNCM

56.16%

Sharpe Ratio

Winner

PTGX

2.09

AGNCM

0.93

5Y Beta

PTGX

0.24

Winner

AGNCM

0.12

Industry

PTGX

Biotechnology

AGNCM

Reit - Mortgage

P/E Ratio

PTGX

110.94

Winner

AGNCM

30.46

Forward P/E

PTGX

30.96

AGNCM

N/A

PEG Ratio

PTGX

2.44

AGNCM

N/A

Dividend Yield

PTGX

N/A

AGNCM

5.73%

5Y Dividends CAGR

PTGX

N/A

AGNCM

9.54%

Debt to Equity

PTGX

0.00%

AGNCM

N/A

Free Cash Flow Yield

PTGX

1.47%

AGNCM

N/A

P/S Ratio

PTGX

117.93

Winner

AGNCM

4.94

P/B Ratio

PTGX

13.40

Winner

AGNCM

2.30

PTGX vs AGNCM - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	AGNCM
1 month	+3.56%	+1.08%
3 months	+47.57%	+2.89%
6 months	+72.65%	+5.05%
1 year	+186.24%	+9.17%
5 years(CAGR)	+24.83%	+7.57%
10 years(CAGR)	+28.74%	N/A
Max(CAGR)	+28.74%	+8.31%

Winner

PTGX

+3.56%

AGNCM

+1.08%

Winner

PTGX

+47.57%

AGNCM

+2.89%

Winner

PTGX

+72.65%

AGNCM

+5.05%

Winner

PTGX

+186.24%

AGNCM

+9.17%

5Y(CAGR)

Winner

PTGX

+24.83%

AGNCM

+7.57%

10Y(CAGR)

PTGX

+28.74%

AGNCM

N/A

Max(CAGR)

Winner

PTGX

+28.74%

AGNCM

+8.31%

PTGX vs AGNCM - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	PTGX	AGNCM
2026	+67.32%	+6.24%
2025	+124.06%	+6.51%
2024	+64.82%	+16.94%
2023	+112.71%	+25.53%
2022	-69.11%	-16.89%
2021	+74.49%	+12.21%
2020	+190.91%	+3.83%
2019	+2.32%	+9.96%
2018	-68.18%	N/A
2017	-1.79%	N/A
2016	+87.95%	N/A

PTGX vs AGNCM Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for AGNCM was -55.99%, occurring on Mar 18, 2020. Recovery took 226 trading sessions.

The current PTGX drawdown is -0.21%.

Rank	PTGX	AGNCM
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-55.99% Feb 3, 2020 - Dec 23, 2020
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-28.38% Jan 3, 2022 - Jul 28, 2023
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-13.96% Sep 29, 2023 - Dec 26, 2023
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-6.49% Apr 1, 2025 - Jun 20, 2025
#5	-19.04% Mar 19, 2021 - May 18, 2021	-3.93% Jul 12, 2021 - Dec 31, 2021
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-3.65% Feb 18, 2026 - Apr 15, 2026
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-3.32% May 7, 2021 - Jun 9, 2021
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-3.04% Dec 30, 2020 - Mar 5, 2021
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-2.45% Aug 29, 2019 - Dec 18, 2019
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-2.36% Oct 7, 2025 - Dec 17, 2025
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	-2.03% Aug 2, 2023 - Aug 24, 2023
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	-1.97% Jun 24, 2025 - Jul 15, 2025
#13	-7.78% Jul 7, 2026 - Jul 17, 2026	-1.88% Dec 31, 2024 - Apr 1, 2025
#14	-7.43% Mar 31, 2026 - Apr 15, 2026	-1.82% Apr 21, 2021 - May 4, 2021
#15	-7.20% Jun 14, 2021 - Jun 16, 2021	-1.63% Dec 28, 2023 - Jan 8, 2024