PTGX vs PRAX

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Praxis Precision Medicines Inc (PRAX, Company).

Both PTGX and PRAX are from the Healthcare sector.

5-Year PerformancePTGX has outperformed PRAX, delivering a return of +23.7% compared to +5.8%

PTGX vs PRAX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	PRAX(COMPANY)
Market Cap	$8.70B	$8.69B
Max Drawdown	85.79%	98.67%
Sharpe Ratio	1.92	1.42
5Y Beta	0.26	0.92
Industry	Biotechnology	Biotechnology
P/E Ratio	-73.60	-22.74
Forward P/E	29.33	N/A
PEG Ratio	0.00	-0.12
5Y EPS CAGR	1.43%	-18.18%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-1.36%	-3.25%
P/S Ratio	117.61	953.14
P/B Ratio	13.57	6.29

Market Cap

Winner

PTGX

$8.70B

PRAX

$8.69B

Max Drawdown

Winner

PTGX

85.79%

PRAX

98.67%

Sharpe Ratio

Winner

PTGX

1.92

PRAX

1.42

5Y Beta

Winner

PTGX

0.26

PRAX

0.92

Industry

PTGX

Biotechnology

PRAX

Biotechnology

P/E Ratio

Winner

PTGX

-73.60

PRAX

-22.74

Forward P/E

PTGX

29.33

PRAX

N/A

PEG Ratio

PTGX

0.00

Winner

PRAX

-0.12

5Y EPS CAGR

Winner

PTGX

1.43%

PRAX

-18.18%

Debt to Equity

PTGX

0.00%

PRAX

0.00%

Free Cash Flow Yield

Winner

PTGX

-1.36%

PRAX

-3.25%

P/S Ratio

Winner

PTGX

117.61

PRAX

953.14

P/B Ratio

PTGX

13.57

Winner

PRAX

6.29

PTGX vs PRAX - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	PRAX
1 month	+11.43%	+5.30%
3 months	+36.11%	-5.66%
6 months	+63.79%	+4.36%
1 year	+153.28%	+460.81%
5 years(CAGR)	+23.68%	+5.76%
10 years(CAGR)	+27.97%	N/A
Max(CAGR)	+27.97%	-4.21%

Winner

PTGX

+11.43%

PRAX

+5.30%

Winner

PTGX

+36.11%

PRAX

-5.66%

Winner

PTGX

+63.79%

PRAX

+4.36%

PTGX

+153.28%

Winner

PRAX

+460.81%

5Y(CAGR)

Winner

PTGX

+23.68%

PRAX

+5.76%

10Y(CAGR)

PTGX

+27.97%

PRAX

N/A

Max(CAGR)

Winner

PTGX

+27.97%

PRAX

-4.21%

PTGX vs PRAX - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	PTGX	PRAX
2026	+56.13%	+13.58%
2025	+124.06%	+270.65%
2024	+64.82%	+268.23%
2023	+112.71%	-42.20%
2022	-69.11%	-88.27%
2021	+74.49%	-63.60%
2020	+190.91%	+97.91%
2019	+2.32%	N/A
2018	-68.18%	N/A
2017	-1.79%	N/A
2016	+87.95%	N/A

PTGX vs PRAX Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for PRAX was -98.67%, occurring on Mar 30, 2023. This drawdown has not yet recovered.

The current PTGX drawdown is -3.41%. The current PRAX drawdown is -63.98%.

Rank	PTGX	PRAX
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-98.67% Jan 7, 2021 - Mar 30, 2023
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-21.78% Nov 9, 2020 - Nov 25, 2020
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-8.01% Dec 28, 2020 - Jan 6, 2021
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-7.00% Dec 11, 2020 - Dec 21, 2020
#5	-19.04% Mar 19, 2021 - May 18, 2021	-6.29% Oct 30, 2020 - Nov 9, 2020
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-4.48% Dec 2, 2020 - Dec 7, 2020
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-3.94% Dec 7, 2020 - Dec 11, 2020
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-3.16% Oct 22, 2020 - Oct 28, 2020
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-1.98% Oct 16, 2020 - Oct 21, 2020
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-1.50% Dec 23, 2020 - Dec 28, 2020
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	N/A
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	N/A
#13	-7.78% Jul 7, 2026 - Jul 17, 2026	N/A
#14	-7.43% Mar 31, 2026 - Apr 15, 2026	N/A
#15	-7.20% Jun 14, 2021 - Jun 16, 2021	N/A