PRAX vs SPY
Comparison between Praxis Precision Medicines Inc (PRAX, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).
5-Year PerformanceSPY has outperformed PRAX, delivering a return of +14.0% compared to +1.2%
PRAX vs SPY - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap / Net Assets
PRAX
$9.66B
Winner
SPY
$735B
Expense Ratio
PRAX
N/A
SPY
0.09%
Max Drawdown
PRAX
98.67%
Winner
SPY
56.47%
Sharpe Ratio
PRAX
1.63
Winner
SPY
1.87
5Y Beta
Winner
PRAX
0.90
SPY
1.00
Industry
PRAX
Biotechnology
SPY
N/A
P/E Ratio
Winner
PRAX
-25.27
SPY
28.55
Forward P/E
PRAX
N/A
SPY
21.99
PEG Ratio
PRAX
-0.14
SPY
N/A
5Y Dividends CAGR
PRAX
N/A
SPY
5.43%
5Y EPS CAGR
PRAX
-18.18%
Winner
SPY
25.29%
Debt to Equity
Winner
PRAX
0.00%
SPY
22.22%
Free Cash Flow Yield
PRAX
-2.92%
SPY
N/A
P/S Ratio
PRAX
N/A
SPY
3.63
P/B Ratio
PRAX
N/A
SPY
5.45
PRAX vs SPY - Historical Returns
Returns include dividend reinvestment.
1M
PRAX
+0.56%
Winner
SPY
+7.73%
3M
PRAX
+8.91%
Winner
SPY
+10.05%
6M
Winner
PRAX
+85.34%
SPY
+11.98%
1Y
Winner
PRAX
+831.32%
SPY
+28.79%
5Y(CAGR)
PRAX
+1.20%
Winner
SPY
+13.98%
10Y(CAGR)
PRAX
N/A
SPY
+15.71%
Max(CAGR)
PRAX
-3.32%
Winner
SPY
+8.55%
PRAX vs SPY - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | PRAX | SPY |
|---|---|---|
| 2026 | +20.64% | +9.82% |
| 2025 | +270.65% | +18.00% |
| 2024 | +268.23% | +25.59% |
| 2023 | -42.20% | +26.72% |
| 2022 | -88.27% | -18.64% |
| 2021 | -63.60% | +30.52% |
| 2020 | +97.91% | +17.28% |
| 2019 | N/A | +31.09% |
| 2018 | N/A | -5.24% |
| 2017 | N/A | +20.78% |
| 2016 | N/A | +13.59% |
| 2015 | N/A | +1.31% |
| 2014 | N/A | +14.56% |
| 2013 | N/A | +29.00% |
| 2012 | N/A | +14.17% |
| 2011 | N/A | +0.85% |
| 2010 | N/A | +13.14% |
| 2009 | N/A | +22.67% |
| 2008 | N/A | -36.25% |
| 2007 | N/A | +5.32% |
| 2006 | N/A | +13.85% |
| 2005 | N/A | +5.32% |
| 2004 | N/A | +10.75% |
| 2003 | N/A | +24.18% |
| 2002 | N/A | -22.42% |
| 2001 | N/A | -10.13% |
| 2000 | N/A | -8.84% |
| 1999 | N/A | +8.61% |
PRAX vs SPY Drawdown Comparison
The maximum drawdown for PRAX was -98.67%, occurring on Mar 30, 2023. This drawdown has not yet recovered.
The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.
The current PRAX drawdown is -61.74%.
| Rank | PRAX | SPY |
|---|---|---|
| #1 | -98.67% Jan 7, 2021 - Mar 30, 2023 | -55.20% Oct 9, 2007 - Aug 16, 2012 |
| #2 | -21.78% Nov 9, 2020 - Nov 25, 2020 | -47.50% Mar 24, 2000 - Oct 26, 2006 |
| #3 | -8.01% Dec 28, 2020 - Jan 6, 2021 | -33.70% Feb 19, 2020 - Aug 10, 2020 |
| #4 | -7.00% Dec 11, 2020 - Dec 21, 2020 | -24.50% Jan 3, 2022 - Dec 13, 2023 |
| #5 | -6.29% Oct 30, 2020 - Nov 9, 2020 | -19.34% Sep 20, 2018 - Apr 12, 2019 |
| #6 | -4.48% Dec 2, 2020 - Dec 7, 2020 | -18.76% Feb 19, 2025 - Jun 26, 2025 |
| #7 | -3.94% Dec 7, 2020 - Dec 11, 2020 | -13.02% Jul 20, 2015 - Apr 18, 2016 |
| #8 | -3.16% Oct 22, 2020 - Oct 28, 2020 | -10.10% Jan 26, 2018 - Aug 6, 2018 |
| #9 | -1.98% Oct 16, 2020 - Oct 21, 2020 | -9.44% Sep 2, 2020 - Nov 11, 2020 |
| #10 | -1.50% Dec 23, 2020 - Dec 28, 2020 | -9.30% Jan 19, 2000 - Mar 17, 2000 |
| #11 | N/A | -9.05% Jul 19, 2007 - Oct 5, 2007 |
| #12 | N/A | -8.88% Jan 27, 2026 - Apr 14, 2026 |
| #13 | N/A | -8.41% Jul 16, 2024 - Sep 19, 2024 |
| #14 | N/A | -7.35% Sep 14, 2012 - Jan 2, 2013 |
| #15 | N/A | -7.27% Sep 18, 2014 - Oct 31, 2014 |
Correlation
Correlation between PRAX and SPY is -0.17 which considered as a very weak or no correlation - the stocks move independently of each other.
-0.17
-101
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