CRNX vs PTGX

Comparison between Crinetics Pharmaceuticals Inc (CRNX, Company) and Protagonist Therapeutics Inc (PTGX, Company).

Both CRNX and PTGX are from the Healthcare sector.

5-Year PerformanceCRNX has outperformed PTGX, delivering a return of +36.7% compared to +24.8%

CRNX vs PTGX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	CRNX(COMPANY)	PTGX(COMPANY)
Market Cap	$8.89B	$8.88B
Max Drawdown	68.70%	85.79%
Sharpe Ratio	1.32	2.09
5Y Beta	0.98	0.24
Industry	Biotechnology	Biotechnology
P/E Ratio	-16.74	110.94
Forward P/E	N/A	30.96
PEG Ratio	-0.73	2.44
5Y EPS CAGR	14.06%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-4.78%	1.47%
P/S Ratio	211.41	117.93
P/B Ratio	6.90	13.40

Market Cap

Winner

CRNX

$8.89B

PTGX

$8.88B

Max Drawdown

Winner

CRNX

68.70%

PTGX

85.79%

Sharpe Ratio

CRNX

1.32

Winner

PTGX

2.09

5Y Beta

CRNX

0.98

Winner

PTGX

0.24

Industry

CRNX

Biotechnology

PTGX

Biotechnology

P/E Ratio

Winner

CRNX

-16.74

PTGX

110.94

Forward P/E

CRNX

N/A

PTGX

30.96

PEG Ratio

Winner

CRNX

-0.73

PTGX

2.44

5Y EPS CAGR

CRNX

14.06%

PTGX

N/A

Debt to Equity

CRNX

0.00%

PTGX

0.00%

Free Cash Flow Yield

CRNX

-4.78%

Winner

PTGX

1.47%

P/S Ratio

CRNX

211.41

Winner

PTGX

117.93

P/B Ratio

Winner

CRNX

6.90

PTGX

13.40

CRNX vs PTGX - Historical Returns

Returns include dividend reinvestment.

Period	CRNX	PTGX
1 month	+0.66%	+3.56%
3 months	+93.33%	+47.57%
6 months	+85.69%	+72.65%
1 year	+201.58%	+186.24%
5 years(CAGR)	+36.70%	+24.83%
10 years(CAGR)	+16.54%	+28.74%
Max(CAGR)	+16.54%	+28.74%

CRNX

+0.66%

Winner

PTGX

+3.56%

Winner

CRNX

+93.33%

PTGX

+47.57%

Winner

CRNX

+85.69%

PTGX

+72.65%

Winner

CRNX

+201.58%

PTGX

+186.24%

5Y(CAGR)

Winner

CRNX

+36.70%

PTGX

+24.83%

10Y(CAGR)

CRNX

+16.54%

Winner

PTGX

+28.74%

Max(CAGR)

CRNX

+16.54%

Winner

PTGX

+28.74%

CRNX vs PTGX - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	CRNX	PTGX
2026	+79.93%	+67.32%
2025	-9.70%	+124.06%
2024	+44.48%	+64.82%
2023	+96.57%	+112.71%
2022	-35.36%	-69.11%
2021	+103.66%	+74.49%
2020	-44.45%	+190.91%
2019	-14.40%	+2.32%
2018	+22.36%	-68.18%
2017	N/A	-1.79%
2016	N/A	+87.95%

CRNX vs PTGX Drawdown Comparison

The maximum drawdown for CRNX was -68.70%, occurring on Mar 16, 2020. Recovery took 1326 trading sessions.

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The current PTGX drawdown is -0.21%.

Rank	CRNX	PTGX
#1	-68.70% Sep 12, 2018 - Dec 19, 2023	-85.79% Sep 1, 2021 - Mar 10, 2025
#2	-57.88% Nov 8, 2024 - Jul 7, 2026	-82.13% Dec 5, 2016 - Feb 16, 2021
#3	-18.72% May 16, 2024 - Jul 11, 2024	-31.58% Mar 11, 2025 - Aug 27, 2025
#4	-17.60% Mar 1, 2024 - Mar 28, 2024	-20.33% Oct 17, 2016 - Nov 10, 2016
#5	-13.35% Jul 16, 2024 - Oct 15, 2024	-19.04% Mar 19, 2021 - May 18, 2021
#6	-12.30% Apr 11, 2024 - May 8, 2024	-16.38% Dec 12, 2025 - Mar 9, 2026
#7	-9.31% Aug 23, 2018 - Sep 6, 2018	-15.52% Oct 10, 2025 - Nov 24, 2025
#8	-8.79% Feb 9, 2024 - Feb 27, 2024	-12.77% Feb 16, 2021 - Mar 2, 2021
#9	-7.55% Jul 18, 2018 - Jul 23, 2018	-12.03% Apr 17, 2026 - Jun 11, 2026
#10	-6.96% Dec 19, 2023 - Jan 9, 2024	-11.53% Aug 19, 2016 - Aug 31, 2016
#11	-6.46% Oct 22, 2024 - Nov 7, 2024	-9.62% Jun 8, 2021 - Jun 11, 2021
#12	-6.38% Jan 9, 2024 - Feb 8, 2024	-8.53% Aug 27, 2025 - Sep 18, 2025
#13	-5.82% May 8, 2024 - May 16, 2024	-7.78% Jul 7, 2026 - Jul 17, 2026
#14	-4.49% Aug 13, 2018 - Aug 17, 2018	-7.43% Mar 31, 2026 - Apr 15, 2026
#15	-4.26% Feb 28, 2024 - Mar 1, 2024	-7.20% Jun 14, 2021 - Jun 16, 2021