XBI vs SPY
Comparison between SPDR(R) S&P(R) BIOTECH ETF (XBI, ETF) and SPDR S&P 500 ETF Trust (SPY, ETF).
5-Year PerformanceSPY has outperformed XBI, delivering a return of +13.3% compared to +1.2%
XBI vs SPY - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Net Assets
XBI
$7.40B
Winner
SPY
$652B
Expense Ratio
XBI
0.35%
Winner
SPY
0.09%
Max Drawdown
XBI
63.90%
Winner
SPY
56.47%
Sharpe Ratio
Winner
XBI
2.19
SPY
2.07
5Y Beta
Winner
XBI
0.97
SPY
1.00
P/E Ratio
Winner
XBI
-10.99
SPY
28.24
Forward P/E
Winner
XBI
11.82
SPY
21.85
5Y Dividends CAGR
Winner
XBI
9.74%
SPY
5.43%
5Y EPS CAGR
XBI
5.78%
Winner
SPY
25.79%
Debt to Equity
XBI
37.46%
Winner
SPY
22.35%
P/S Ratio
XBI
8.33
Winner
SPY
3.55
P/B Ratio
Winner
XBI
4.84
SPY
5.29
XBI vs SPY - Holdings Comparison
XBI and SPY have 9 common holdings. Overlap is 1.44%
XBI's top 25 holdings weight is 32.10%. SPY's top 25 holdings weight is 51.32%.
| Rank | XBI | SPY |
|---|---|---|
| #1 | APELLIS PHARMACEUTICALS INC (APLS) - 1.75% | NVIDIA CORP (NVDA) - 8.45% |
| #2 | SUMMIT THERAPEUTICS INC ORDINARY SHARES (SMMT) - 1.62% | APPLE INC (AAPL) - 6.48% |
| #3 | REVOLUTION MEDICINES INC ORDINARY SHARES (RVMD) - 1.60% | MICROSOFT CORP (MSFT) - 5.20% |
| #4 | TWIST BIOSCIENCE CORP (TWST) - 1.43% | AMAZON.COM INC (AMZN) - 4.14% |
| #5 | TRAVERE THERAPEUTICS INC ORDINARY SHARES (TVTX) - 1.40% | ALPHABET INC CLASS A (GOOGL) - 3.32% |
| #6 | TG THERAPEUTICS INC (TGTX) - 1.38% | BROADCOM INC (AVGO) - 3.09% |
| #7 | ERASCA INC (ERAS) - 1.34% | ALPHABET INC CLASS C (GOOG) - 2.65% |
| #8 | ARROWHEAD PHARMACEUTICALS INC (ARWR) - 1.31% | META PLATFORMS INC CLASS A (META) - 2.40% |
| #9 | MADRIGAL PHARMACEUTICALS INC (MDGL) - 1.31% | TESLA INC (TSLA) - 1.73% |
| #10 | APOGEE THERAPEUTICS INC (APGE) - 1.30% | BERKSHIRE HATHAWAY INC CLASS B (BRK-B) - 1.43% |
| #11 | ALKERMES PLC (ALKS) - 1.29% | JPMORGAN CHASE & CO (JPM) - 1.37% |
| #12 | BEAM THERAPEUTICS INC (BEAM) - 1.26% | ELI LILLY AND CO (LLY) - 1.13% |
| #13 | n/a (PRAX) - 1.23% | EXXON MOBIL CORP (XOM) - 1.03% |
| #14 | SCHOLAR ROCK HOLDING CORP (SRRK) - 1.19% | MICRON TECHNOLOGY INC (MU) - 0.93% |
| #15 | CRISPR THERAPEUTICS AG (CRSP) - 1.19% | WALMART INC (WMT) - 0.91% |
| #16 | EXELIXIS INC (EXEL) - 1.17% | JOHNSON & JOHNSON (JNJ) - 0.90% |
| #17 | PROTAGONIST THERAPEUTICS INC (PTGX) - 1.17% | ADVANCED MICRO DEVICES INC (AMD) - 0.86% |
| #18 | CELCUITY INC (CELC) - 1.16% | VISA INC CLASS A (V) - 0.85% |
| #19 | CG ONCOLOGY INC (CGON) - 1.16% | COSTCO WHOLESALE CORP (COST) - 0.72% |
| #20 | PTC THERAPEUTICS INC (PTCT) - 1.15% | MASTERCARD INC CLASS A (MA) - 0.67% |
| #21 | KYMERA THERAPEUTICS INC ORDINARY SHARES (KYMR) - 1.15% | INTEL CORP (INTC) - 0.65% |
| #22 | BRIDGEBIO PHARMA INC (BBIO) - 1.14% | NETFLIX INC (NFLX) - 0.64% |
| #23 | NUVALENT INC CLASS A (NUVL) - 1.14% | CATERPILLAR INC (CAT) - 0.62% |
| #24 | KRYSTAL BIOTECH INC (KRYS) - 1.14% | CHEVRON CORP (CVX) - 0.58% |
| #25 | UNITED THERAPEUTICS CORP (UTHR) - 1.12% | PROCTER & GAMBLE CO (PG) - 0.57% |
| Total Holdings | 157 | 505 |
XBI vs SPY - Historical Returns
Returns include dividend reinvestment.
1M
XBI
+3.11%
Winner
SPY
+9.11%
3M
Winner
XBI
+6.82%
SPY
+6.59%
6M
Winner
XBI
+24.03%
SPY
+10.56%
1Y
Winner
XBI
+73.24%
SPY
+32.04%
5Y(CAGR)
XBI
+1.17%
Winner
SPY
+13.35%
10Y(CAGR)
XBI
+10.10%
Winner
SPY
+15.49%
Max(CAGR)
Winner
XBI
+11.26%
SPY
+8.50%
XBI vs SPY - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | XBI | SPY |
|---|---|---|
| 2026 | +10.85% | +8.27% |
| 2025 | +33.70% | +18.00% |
| 2024 | -0.05% | +25.59% |
| 2023 | +9.54% | +26.72% |
| 2022 | -28.10% | -18.64% |
| 2021 | -20.55% | +30.52% |
| 2020 | +49.01% | +17.28% |
| 2019 | +30.54% | +31.09% |
| 2018 | -17.55% | -5.24% |
| 2017 | +42.81% | +20.78% |
| 2016 | -12.49% | +13.59% |
| 2015 | +12.40% | +1.31% |
| 2014 | +44.27% | +14.56% |
| 2013 | +42.97% | +29.00% |
| 2012 | +32.95% | +14.17% |
| 2011 | +3.91% | +0.85% |
| 2010 | +15.74% | +13.14% |
| 2009 | -0.82% | +22.67% |
| 2008 | -8.58% | -36.25% |
| 2007 | +30.24% | +5.32% |
| 2006 | -6.48% | +13.85% |
| 2005 | N/A | +5.32% |
| 2004 | N/A | +10.75% |
| 2003 | N/A | +24.18% |
| 2002 | N/A | -22.42% |
| 2001 | N/A | -10.13% |
| 2000 | N/A | -8.84% |
| 1999 | N/A | +8.61% |
XBI vs SPY Drawdown Comparison
The maximum drawdown for XBI was -63.89%, occurring on May 11, 2022. This drawdown has not yet recovered.
The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.
The current XBI drawdown is -22.15%.
| Rank | XBI | SPY |
|---|---|---|
| #1 | -63.89% Feb 8, 2021 - May 11, 2022 | -55.20% Oct 9, 2007 - Aug 16, 2012 |
| #2 | -49.25% Jul 17, 2015 - Jan 12, 2018 | -47.50% Mar 24, 2000 - Oct 26, 2006 |
| #3 | -37.67% Aug 14, 2008 - Apr 14, 2011 | -33.70% Feb 19, 2020 - Aug 10, 2020 |
| #4 | -35.26% Jun 20, 2018 - May 11, 2020 | -24.50% Jan 3, 2022 - Dec 13, 2023 |
| #5 | -29.06% Feb 27, 2014 - Oct 28, 2014 | -19.34% Sep 20, 2018 - Apr 12, 2019 |
| #6 | -26.72% Jul 22, 2011 - Jan 27, 2012 | -18.76% Feb 19, 2025 - Jun 26, 2025 |
| #7 | -22.71% Dec 6, 2007 - Jul 15, 2008 | -13.02% Jul 20, 2015 - Apr 18, 2016 |
| #8 | -21.93% Feb 27, 2006 - Aug 8, 2007 | -10.10% Jan 26, 2018 - Aug 6, 2018 |
| #9 | -15.10% Sep 21, 2012 - Jan 14, 2013 | -9.44% Sep 2, 2020 - Nov 11, 2020 |
| #10 | -14.51% Jan 29, 2018 - Jun 5, 2018 | -9.30% Jan 19, 2000 - Mar 17, 2000 |
| #11 | -13.70% Jul 20, 2020 - Oct 12, 2020 | -9.05% Jul 19, 2007 - Oct 5, 2007 |
| #12 | -13.36% Oct 2, 2013 - Jan 7, 2014 | -8.88% Jan 27, 2026 - Apr 14, 2026 |
| #13 | -13.21% Mar 19, 2015 - May 29, 2015 | -8.41% Jul 16, 2024 - Sep 19, 2024 |
| #14 | -11.51% Jan 21, 2014 - Feb 20, 2014 | -7.35% Sep 14, 2012 - Jan 2, 2013 |
| #15 | -10.38% May 30, 2013 - Jul 10, 2013 | -7.27% Sep 18, 2014 - Oct 31, 2014 |
Correlation
Correlation between XBI and SPY is 0.81 which considered as a strong positive correlation - the stocks tend to move together.
0.81
-101
Dividend Comparison (1999 - 2026)
XBI vs SPY dividend yield comparison.
| Year | XBI | SPY |
|---|---|---|
| 2026 | 0.00% | 0.24% |
| 2025 | 0.37% | 1.07% |
| 2024 | 0.15% | 1.21% |
| 2023 | 0.02% | 1.40% |
| 2022 | 0.00% | 1.65% |
| 2021 | 0.04% | 1.20% |
| 2020 | 0.20% | 1.52% |
| 2019 | 0.00% | 1.75% |
| 2018 | 0.28% | 2.04% |
| 2017 | 0.24% | 1.80% |
| 2016 | 0.26% | 2.03% |
| 2015 | 0.61% | 2.06% |
| 2014 | 1.07% | 1.87% |
| 2013 | 0.17% | 1.81% |
| 2012 | 0.22% | 2.18% |
| 2011 | 0.00% | 2.05% |
| 2010 | 0.00% | 1.80% |
| 2009 | 0.28% | 1.95% |
| 2008 | 1.27% | 3.02% |
| 2007 | 0.26% | 1.85% |
| 2006 | 0.00% | 1.73% |
| 2005 | 0.00% | 1.73% |
| 2004 | 0.00% | 1.82% |
| 2003 | 0.00% | 1.47% |
| 2002 | 0.00% | 1.70% |
| 2001 | 0.00% | 1.25% |
| 2000 | 0.00% | 1.15% |
| 1999 | 0.00% | 0.24% |
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