SYRE vs Z

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Zillow Group Inc - Class C (Z, Company).

SYRE is from the Healthcare sector, while Z is from the Communication Services sector.

5-Year PerformanceSYRE has outperformed Z, delivering a return of -10.2% compared to -20.2%

SYRE vs Z - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	Z(COMPANY)
Market Cap	$8.05B	$7.98B
Max Drawdown	99.11%	86.51%
Sharpe Ratio	2.92	-1.71
5Y Beta	1.76	1.20
Industry	Biotechnology	Internet Content & Information
P/E Ratio	-41.36	121.85
Forward P/E	N/A	14.31
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-2.31%	4.17%

Market Cap

Winner

SYRE

$8.05B

$7.98B

Max Drawdown

SYRE

99.11%

Winner

86.51%

Sharpe Ratio

Winner

SYRE

2.92

-1.71

5Y Beta

SYRE

1.76

Winner

1.20

Industry

SYRE

Biotechnology

Internet Content & Information

P/E Ratio

Winner

SYRE

-41.36

121.85

Forward P/E

SYRE

N/A

14.31

5Y EPS CAGR

SYRE

-2.15%

N/A

Debt to Equity

SYRE

0.00%

Free Cash Flow Yield

SYRE

-2.31%

Winner

4.17%

SYRE vs Z - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	Z
1 month	+22.12%	+4.59%
3 months	+47.95%	-22.20%
6 months	+208.46%	-50.15%
1 year	+566.69%	-55.83%
5 years(CAGR)	-10.25%	-20.25%
10 years(CAGR)	-1.01%	-0.96%
Max(CAGR)	-8.15%	+1.83%

Winner

SYRE

+22.12%

+4.59%

Winner

SYRE

+47.95%

-22.20%

Winner

SYRE

+208.46%

-50.15%

Winner

SYRE

+566.69%

-55.83%

5Y(CAGR)

Winner

SYRE

-10.25%

-20.25%

10Y(CAGR)

SYRE

-1.01%

Winner

-0.96%

Max(CAGR)

SYRE

-8.15%

Winner

+1.83%

SYRE vs Z - Annual Returns (2015 - 2026)

Returns include dividend reinvestment.

Year	SYRE	Z
2026	+233.78%	-48.66%
2025	+37.36%	-6.73%
2024	+8.79%	+29.34%
2023	+104.27%	+71.79%
2022	-90.57%	-49.23%
2021	-44.51%	-51.17%
2020	+1.55%	+187.10%
2019	-4.98%	+51.37%
2018	+39.22%	-25.66%
2017	+18.38%	+9.94%
2016	-55.48%	+64.95%
2015	N/A	-15.36%

SYRE vs Z Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for Z was -86.51%, occurring on Oct 14, 2022. This drawdown has not yet recovered.

The current SYRE drawdown is -65.95%. The current Z drawdown is -83.07%.

Rank	SYRE	Z
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-86.51% Feb 16, 2021 - Oct 14, 2022
#2	N/A	-61.86% Jun 15, 2018 - Jul 20, 2020
#3	N/A	-52.14% Oct 9, 2015 - Jun 17, 2016
#4	N/A	-25.94% Jun 23, 2017 - Mar 5, 2018
#5	N/A	-19.92% Mar 14, 2018 - Jun 1, 2018
#6	N/A	-19.75% Aug 1, 2016 - May 1, 2017
#7	N/A	-19.52% Oct 5, 2020 - Nov 6, 2020
#8	N/A	-15.23% Nov 6, 2020 - Dec 10, 2020
#9	N/A	-14.18% Jan 20, 2021 - Feb 4, 2021
#10	N/A	-12.15% Aug 3, 2015 - Sep 17, 2015
#11	N/A	-9.66% Sep 2, 2020 - Sep 15, 2020
#12	N/A	-8.09% Dec 23, 2020 - Jan 7, 2021
#13	N/A	-7.55% May 16, 2017 - Jun 1, 2017
#14	N/A	-7.26% Jun 23, 2016 - Jun 30, 2016
#15	N/A	-6.98% Sep 18, 2015 - Oct 6, 2015