SYRE vs CIFR

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Cipher Mining Inc (CIFR, Company).

SYRE is from the Healthcare sector, while CIFR is from the Technology sector.

5-Year PerformanceCIFR has outperformed SYRE, delivering a return of +14.9% compared to -10.2%

SYRE vs CIFR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	CIFR(COMPANY)
Market Cap	$8.05B	$8.05B
Max Drawdown	99.11%	97.16%
Sharpe Ratio	2.92	1.60
5Y Beta	1.76	3.26
Industry	Biotechnology	Information Technology Services
P/E Ratio	-41.36	-8.94
Forward P/E	N/A	85.47
PEG Ratio	N/A	-0.02
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	662.59%
Free Cash Flow Yield	-2.31%	-13.49%

Market Cap

SYRE

$8.05B

Winner

CIFR

$8.05B

Max Drawdown

SYRE

99.11%

Winner

CIFR

97.16%

Sharpe Ratio

Winner

SYRE

2.92

CIFR

1.60

5Y Beta

Winner

SYRE

1.76

CIFR

3.26

Industry

SYRE

Biotechnology

CIFR

Information Technology Services

P/E Ratio

Winner

SYRE

-41.36

CIFR

-8.94

Forward P/E

SYRE

N/A

CIFR

85.47

PEG Ratio

SYRE

N/A

CIFR

-0.02

5Y EPS CAGR

SYRE

-2.15%

CIFR

N/A

Debt to Equity

Winner

SYRE

0.00%

CIFR

662.59%

Free Cash Flow Yield

Winner

SYRE

-2.31%

CIFR

-13.49%

SYRE vs CIFR - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	CIFR
1 month	+22.12%	-23.67%
3 months	+47.95%	+10.39%
6 months	+208.46%	+13.41%
1 year	+566.69%	+232.83%
5 years(CAGR)	-10.25%	+14.88%
10 years(CAGR)	-1.01%	N/A
Max(CAGR)	-8.15%	+13.45%

Winner

SYRE

+22.12%

CIFR

-23.67%

Winner

SYRE

+47.95%

CIFR

+10.39%

Winner

SYRE

+208.46%

CIFR

+13.41%

Winner

SYRE

+566.69%

CIFR

+232.83%

5Y(CAGR)

SYRE

-10.25%

Winner

CIFR

+14.88%

10Y(CAGR)

SYRE

-1.01%

CIFR

N/A

Max(CAGR)

SYRE

-8.15%

Winner

CIFR

+13.45%

SYRE vs CIFR - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	CIFR
2026	+233.78%	+22.65%
2025	+37.36%	+205.59%
2024	+8.79%	+12.35%
2023	+104.27%	+545.62%
2022	-90.57%	-87.85%
2021	-44.51%	-53.61%
2020	+1.55%	+1.53%
2019	-4.98%	N/A
2018	+39.22%	N/A
2017	+18.38%	N/A
2016	-55.48%	N/A

SYRE vs CIFR Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for CIFR was -97.16%, occurring on Dec 28, 2022. Recovery took 1016 trading sessions.

The current SYRE drawdown is -65.95%. The current CIFR drawdown is -31.91%.

Rank	SYRE	CIFR
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-97.16% Sep 16, 2021 - Oct 3, 2025
#2	N/A	-51.38% Nov 5, 2025 - May 27, 2026
#3	N/A	-31.91% Jun 18, 2026 - Jul 14, 2026
#4	N/A	-23.40% Oct 15, 2025 - Nov 3, 2025
#5	N/A	-21.54% Mar 11, 2021 - Sep 9, 2021
#6	N/A	-20.05% Jun 2, 2026 - Jun 17, 2026
#7	N/A	-6.00% May 27, 2026 - Jun 2, 2026
#8	N/A	-5.67% Oct 9, 2025 - Oct 13, 2025
#9	N/A	-5.50% Sep 13, 2021 - Sep 16, 2021
#10	N/A	-4.21% Feb 19, 2021 - Mar 5, 2021
#11	N/A	-1.63% Jan 25, 2021 - Feb 19, 2021
#12	N/A	-1.13% Mar 9, 2021 - Mar 11, 2021
#13	N/A	-1.10% Nov 3, 2025 - Nov 5, 2025
#14	N/A	-1.08% Mar 5, 2021 - Mar 9, 2021
#15	N/A	-0.50% Dec 28, 2020 - Jan 6, 2021