SYRE vs JHG

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Janus Henderson Group plc Ordinary Shares (JHG, Company).

SYRE is from the Healthcare sector, while JHG is from the Financial Services sector.

5-Year PerformanceJHG has outperformed SYRE, delivering a return of +10.6% compared to -10.2%

SYRE vs JHG - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	JHG(COMPANY)
Market Cap	$8.05B	$8B
Max Drawdown	99.11%	92.68%
Sharpe Ratio	2.92	1.39
5Y Beta	1.76	N/A
Industry	Biotechnology	Asset Management
P/E Ratio	-41.36	10.22
Forward P/E	N/A	12.00
PEG Ratio	N/A	0.10
Dividend Yield	N/A	1.54%
5Y Dividends CAGR	N/A	2.00%
5Y EPS CAGR	-2.15%	9.39%
Debt to Equity	0.00%	7.64%
Free Cash Flow Yield	-2.31%	11.76%

Market Cap

Winner

SYRE

$8.05B

JHG

$8B

Max Drawdown

SYRE

99.11%

Winner

JHG

92.68%

Sharpe Ratio

Winner

SYRE

2.92

JHG

1.39

5Y Beta

SYRE

1.76

JHG

N/A

Industry

SYRE

Biotechnology

JHG

Asset Management

P/E Ratio

Winner

SYRE

-41.36

JHG

10.22

Forward P/E

SYRE

N/A

JHG

12.00

PEG Ratio

SYRE

N/A

JHG

0.10

Dividend Yield

SYRE

N/A

JHG

1.54%

5Y Dividends CAGR

SYRE

N/A

JHG

2.00%

5Y EPS CAGR

SYRE

-2.15%

Winner

JHG

9.39%

Debt to Equity

Winner

SYRE

0.00%

JHG

7.64%

Free Cash Flow Yield

SYRE

-2.31%

Winner

JHG

11.76%

SYRE vs JHG - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	JHG
1 month	+22.12%	+0.43%
3 months	+47.95%	+1.03%
6 months	+208.46%	+9.21%
1 year	+566.69%	+34.10%
5 years(CAGR)	-10.25%	+10.64%
10 years(CAGR)	-1.01%	+10.48%
Max(CAGR)	-8.15%	-0.05%

Winner

SYRE

+22.12%

JHG

+0.43%

Winner

SYRE

+47.95%

JHG

+1.03%

Winner

SYRE

+208.46%

JHG

+9.21%

Winner

SYRE

+566.69%

JHG

+34.10%

5Y(CAGR)

SYRE

-10.25%

Winner

JHG

+10.64%

10Y(CAGR)

SYRE

-1.01%

Winner

JHG

+10.48%

Max(CAGR)

SYRE

-8.15%

Winner

JHG

-0.05%

SYRE vs JHG - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	SYRE	JHG
2026	+233.78%	+8.73%
2025	+37.36%	+14.66%
2024	+8.79%	+48.50%
2023	+104.27%	+33.06%
2022	-90.57%	-40.58%
2021	-44.51%	+38.94%
2020	+1.55%	+41.59%
2019	-4.98%	+26.37%
2018	+39.22%	-43.67%
2017	+18.38%	+36.64%
2016	-55.48%	-3.63%
2015	N/A	-12.32%
2014	N/A	+33.42%
2013	N/A	+38.21%
2012	N/A	+28.70%
2011	N/A	-52.91%
2010	N/A	-6.22%
2009	N/A	+50.28%
2008	N/A	-74.57%
2007	N/A	+51.59%
2006	N/A	+14.23%
2005	N/A	+13.60%
2004	N/A	+0.66%
2003	N/A	+23.20%
2002	N/A	-51.63%
2001	N/A	-22.91%
2000	N/A	+2.76%

SYRE vs JHG Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for JHG was -92.68%, occurring on Mar 2, 2009. This drawdown has not yet recovered.

The current SYRE drawdown is -65.95%. The current JHG drawdown is -29.76%.

Rank	SYRE	JHG
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-92.68% Sep 11, 2000 - Mar 2, 2009
#2	N/A	-18.24% Jul 24, 2000 - Sep 7, 2000
#3	N/A	-8.92% Jul 14, 2000 - Jul 21, 2000

Correlation

Correlation between SYRE and JHG is -0.49 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.49

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