SYRE vs CLF

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Cleveland-Cliffs Inc (CLF, Company).

SYRE is from the Healthcare sector, while CLF is from the Basic Materials sector.

5-Year PerformanceCLF has outperformed SYRE, delivering a return of -9.5% compared to -11.3%

SYRE vs CLF - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	CLF(COMPANY)
Market Cap	$6.96B	$7B
Max Drawdown	99.11%	98.94%
Sharpe Ratio	2.89	0.98
5Y Beta	1.76	1.95
Industry	Biotechnology	Steel
P/E Ratio	-35.79	-5.28
Forward P/E	N/A	29.67
5Y Dividends CAGR	N/A	-6.01%
5Y EPS CAGR	-2.15%	81.08%
Debt to Equity	0.00%	133.34%
Free Cash Flow Yield	-2.67%	-14.23%

Market Cap

SYRE

$6.96B

Winner

CLF

$7B

Max Drawdown

SYRE

99.11%

Winner

CLF

98.94%

Sharpe Ratio

Winner

SYRE

2.89

CLF

0.98

5Y Beta

Winner

SYRE

1.76

CLF

1.95

Industry

SYRE

Biotechnology

CLF

Steel

P/E Ratio

Winner

SYRE

-35.79

CLF

-5.28

Forward P/E

SYRE

N/A

CLF

29.67

5Y Dividends CAGR

SYRE

N/A

CLF

-6.01%

5Y EPS CAGR

SYRE

-2.15%

Winner

CLF

81.08%

Debt to Equity

Winner

SYRE

0.00%

CLF

133.34%

Free Cash Flow Yield

Winner

SYRE

-2.67%

CLF

-14.23%

SYRE vs CLF - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	CLF
1 month	+26.06%	+15.20%
3 months	+105.16%	+50.12%
6 months	+163.94%	-5.39%
1 year	+485.81%	+67.53%
5 years(CAGR)	-11.31%	-9.54%
10 years(CAGR)	-2.30%	+10.19%
Max(CAGR)	-9.49%	+5.98%

Winner

SYRE

+26.06%

CLF

+15.20%

Winner

SYRE

+105.16%

CLF

+50.12%

Winner

SYRE

+163.94%

CLF

-5.39%

Winner

SYRE

+485.81%

CLF

+67.53%

5Y(CAGR)

SYRE

-11.31%

Winner

CLF

-9.54%

10Y(CAGR)

SYRE

-2.30%

Winner

CLF

+10.19%

Max(CAGR)

SYRE

-9.49%

Winner

CLF

+5.98%

SYRE vs CLF - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SYRE	CLF
2026	+188.88%	-9.71%
2025	+37.36%	+39.20%
2024	+8.79%	-52.45%
2023	+104.27%	+21.62%
2022	-90.57%	-25.86%
2021	-44.51%	+50.97%
2020	+1.55%	+88.69%
2019	-4.98%	+10.16%
2018	+39.22%	-2.66%
2017	+18.38%	-16.26%
2016	-55.48%	+403.59%
2015	N/A	-77.52%
2014	N/A	-71.27%
2013	N/A	-30.80%
2012	N/A	-38.56%
2011	N/A	-23.00%
2010	N/A	+63.25%
2009	N/A	+57.60%
2008	N/A	-46.54%
2007	N/A	+112.27%
2006	N/A	+5.86%
2005	N/A	+76.79%
2004	N/A	+95.85%
2003	N/A	+147.09%
2002	N/A	+7.53%
2001	N/A	-14.70%
2000	N/A	-24.00%
1999	N/A	+8.53%

SYRE vs CLF Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for CLF was -98.78%, occurring on Jan 12, 2016. This drawdown has not yet recovered.

The current SYRE drawdown is -70.53%. The current CLF drawdown is -87.44%.

Rank	SYRE	CLF
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-98.78% Jun 30, 2008 - Jan 12, 2016
#2	N/A	-51.61% Dec 27, 1999 - Apr 15, 2002
#3	N/A	-48.31% Apr 18, 2002 - Oct 13, 2003
#4	N/A	-41.76% Mar 4, 2004 - Sep 2, 2004
#5	N/A	-41.09% Feb 1, 2006 - Jan 30, 2007
#6	N/A	-38.96% Mar 4, 2005 - Sep 28, 2005
#7	N/A	-32.10% Jun 1, 2007 - Oct 1, 2007
#8	N/A	-27.95% Oct 12, 2007 - Dec 26, 2007
#9	N/A	-21.75% Jan 5, 2004 - Feb 17, 2004
#10	N/A	-20.24% Oct 6, 2004 - Nov 11, 2004
#11	N/A	-18.57% Dec 28, 2007 - Feb 1, 2008
#12	N/A	-17.14% Feb 28, 2008 - Apr 1, 2008
#13	N/A	-16.03% Sep 30, 2005 - Nov 9, 2005
#14	N/A	-12.12% Jun 5, 2008 - Jun 23, 2008
#15	N/A	-11.79% Feb 26, 2007 - Mar 20, 2007

Correlation

Correlation between SYRE and CLF is -0.39 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.39

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