SPRO vs ANTA

Comparison between Spero Therapeutics Inc (SPRO, Company) and Antalpha Platform Holding Company (ANTA, Company).

SPRO is from the Healthcare sector, while ANTA is from the Financial Services sector.

SPRO vs ANTA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SPRO(COMPANY)	ANTA(COMPANY)
Market Cap	$147M	$147M
Max Drawdown	97.46%	60.62%
Sharpe Ratio	0.09	-0.54
5Y Beta	0.60	1.40
Industry	Biotechnology	Credit Services
P/E Ratio	9.31	6.00
Forward P/E	N/A	35.46
PEG Ratio	0.00	0.02
5Y Dividends CAGR	30.26%	N/A
Debt to Equity	0.00%	13.20%
Free Cash Flow Yield	4.93%	-2.88%
P/S Ratio	2.42	1.83
P/B Ratio	2.81	1.29

Market Cap

Winner

SPRO

$147M

ANTA

$147M

Max Drawdown

SPRO

97.46%

Winner

ANTA

60.62%

Sharpe Ratio

Winner

SPRO

0.09

ANTA

-0.54

5Y Beta

Winner

SPRO

0.60

ANTA

1.40

Industry

SPRO

Biotechnology

ANTA

Credit Services

P/E Ratio

SPRO

9.31

Winner

ANTA

6.00

Forward P/E

SPRO

N/A

ANTA

35.46

PEG Ratio

Winner

SPRO

0.00

ANTA

0.02

5Y Dividends CAGR

SPRO

30.26%

ANTA

N/A

Debt to Equity

Winner

SPRO

0.00%

ANTA

13.20%

Free Cash Flow Yield

Winner

SPRO

4.93%

ANTA

-2.88%

P/S Ratio

SPRO

2.42

Winner

ANTA

1.83

P/B Ratio

SPRO

2.81

Winner

ANTA

1.29

SPRO vs ANTA - Historical Returns

Returns include dividend reinvestment.

Period	SPRO	ANTA
1 month	+12.20%	-21.74%
3 months	+10.04%	-11.63%
6 months	+22.84%	-32.35%
1 year	-1.38%	-44.84%
5 years(CAGR)	-28.65%	N/A
10 years(CAGR)	-2.10%	N/A
Max(CAGR)	-0.31%	-43.98%

Winner

SPRO

+12.20%

ANTA

-21.74%

Winner

SPRO

+10.04%

ANTA

-11.63%

Winner

SPRO

+22.84%

ANTA

-32.35%

Winner

SPRO

-1.38%

ANTA

-44.84%

5Y(CAGR)

SPRO

-28.65%

ANTA

N/A

10Y(CAGR)

SPRO

-2.10%

ANTA

N/A

Max(CAGR)

Winner

SPRO

-0.31%

ANTA

-43.98%

SPRO vs ANTA - Annual Returns (2004 - 2026)

Returns include dividend reinvestment.

Year	SPRO	ANTA
2026	+21.28%	-25.08%
2025	+115.74%	-30.55%
2024	-32.24%	N/A
2023	-15.52%	N/A
2022	-88.58%	N/A
2021	-10.71%	N/A
2020	+96.45%	N/A
2019	+53.59%	N/A
2018	-49.34%	N/A
2017	+2.17%	N/A
2015	+125.03%	N/A
2014	-36.85%	N/A
2013	+87.73%	N/A
2012	-15.94%	N/A
2011	-18.88%	N/A
2010	-29.17%	N/A
2009	+37.55%	N/A
2008	-59.66%	N/A
2007	+44.06%	N/A
2006	+26.56%	N/A
2005	-15.34%	N/A
2004	+7.04%	N/A

SPRO vs ANTA Drawdown Comparison

The maximum drawdown for SPRO was -97.46%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for ANTA was -60.62%, occurring on Jun 8, 2026. This drawdown has not yet recovered.

The current SPRO drawdown is -87.09%. The current ANTA drawdown is -58.24%.

Rank	SPRO	ANTA
#1	-97.46% Dec 28, 2020 - Apr 8, 2025	-60.62% May 14, 2025 - Jun 8, 2026
#2	-85.13% Jul 17, 2007 - Nov 2, 2017	N/A
#3	-70.48% Apr 12, 2018 - Dec 8, 2020	N/A
#4	-42.56% May 17, 2005 - Feb 16, 2007	N/A
#5	-32.47% Nov 13, 2017 - Apr 9, 2018	N/A
#6	-18.79% Mar 12, 2007 - Jun 19, 2007	N/A
#7	-9.16% Jun 25, 2007 - Jul 3, 2007	N/A
#8	-8.75% Dec 3, 2004 - Mar 28, 2005	N/A
#9	-5.73% Feb 21, 2007 - Mar 7, 2007	N/A
#10	-5.34% Dec 8, 2020 - Dec 16, 2020	N/A
#11	-4.94% Mar 28, 2005 - May 11, 2005	N/A
#12	-4.48% Dec 17, 2020 - Dec 21, 2020	N/A
#13	-4.01% Jul 9, 2007 - Jul 13, 2007	N/A
#14	-2.82% Nov 22, 2004 - Nov 24, 2004	N/A
#15	-2.50% Nov 24, 2004 - Dec 1, 2004	N/A

Correlation

Correlation between SPRO and ANTA is -0.40 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.40

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