SPRO vs AMBI

Comparison between Spero Therapeutics Inc (SPRO, Company) and Ambipar Emergency Response - Class A (AMBI, Company).

SPRO is from the Healthcare sector, while AMBI is from the Industrials sector.

SPRO vs AMBI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SPRO(COMPANY)	AMBI(COMPANY)
Market Cap	$147M	$148M
Max Drawdown	97.46%	96.93%
Sharpe Ratio	0.09	-1.30
5Y Beta	0.60	N/A
Industry	Biotechnology	Waste Management
P/E Ratio	9.31	-103.26
PEG Ratio	0.00	N/A
5Y Dividends CAGR	30.26%	N/A
Debt to Equity	0.00%	N/A
Free Cash Flow Yield	4.93%	N/A
P/S Ratio	2.42	0.27
P/B Ratio	2.81	0.81

Market Cap

SPRO

$147M

Winner

AMBI

$148M

Max Drawdown

SPRO

97.46%

Winner

AMBI

96.93%

Sharpe Ratio

Winner

SPRO

0.09

AMBI

-1.30

5Y Beta

SPRO

0.60

AMBI

N/A

Industry

SPRO

Biotechnology

AMBI

Waste Management

P/E Ratio

SPRO

9.31

Winner

AMBI

-103.26

PEG Ratio

SPRO

0.00

AMBI

N/A

5Y Dividends CAGR

SPRO

30.26%

AMBI

N/A

Debt to Equity

SPRO

0.00%

AMBI

N/A

Free Cash Flow Yield

SPRO

4.93%

AMBI

N/A

P/S Ratio

SPRO

2.42

Winner

AMBI

0.27

P/B Ratio

SPRO

2.81

Winner

AMBI

0.81

SPRO vs AMBI - Historical Returns

Returns include dividend reinvestment.

Period	SPRO	AMBI
1 month	+12.20%	+0.00%
3 months	+10.04%	+0.00%
6 months	+22.84%	+0.00%
1 year	-1.38%	-88.57%
5 years(CAGR)	-28.65%	N/A
10 years(CAGR)	-2.10%	N/A
Max(CAGR)	-0.31%	-65.45%

Winner

SPRO

+12.20%

AMBI

+0.00%

Winner

SPRO

+10.04%

AMBI

+0.00%

Winner

SPRO

+22.84%

AMBI

+0.00%

Winner

SPRO

-1.38%

AMBI

-88.57%

5Y(CAGR)

SPRO

-28.65%

AMBI

N/A

10Y(CAGR)

SPRO

-2.10%

AMBI

N/A

Max(CAGR)

Winner

SPRO

-0.31%

AMBI

-65.45%

SPRO vs AMBI - Annual Returns (2004 - 2026)

Returns include dividend reinvestment.

Year	SPRO	AMBI
2026	+21.28%	+0.00%
2025	+115.74%	-89.91%
2024	-32.24%	-30.21%
2023	-15.52%	-55.38%
2022	-88.58%	N/A
2021	-10.71%	N/A
2020	+96.45%	N/A
2019	+53.59%	N/A
2018	-49.34%	N/A
2017	+2.17%	N/A
2015	+125.03%	N/A
2014	-36.85%	N/A
2013	+87.73%	N/A
2012	-15.94%	N/A
2011	-18.88%	N/A
2010	-29.17%	N/A
2009	+37.55%	N/A
2008	-59.66%	N/A
2007	+44.06%	N/A
2006	+26.56%	N/A
2005	-15.34%	N/A
2004	+7.04%	N/A

SPRO vs AMBI Drawdown Comparison

The maximum drawdown for SPRO was -97.46%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for AMBI was -96.93%, occurring on Oct 28, 2025. This drawdown has not yet recovered.

The current SPRO drawdown is -87.09%. The current AMBI drawdown is -96.93%.

Rank	SPRO	AMBI
#1	-97.46% Dec 28, 2020 - Apr 8, 2025	-96.93% Mar 3, 2023 - Oct 28, 2025
#2	-85.13% Jul 17, 2007 - Nov 2, 2017	N/A
#3	-70.48% Apr 12, 2018 - Dec 8, 2020	N/A
#4	-42.56% May 17, 2005 - Feb 16, 2007	N/A
#5	-32.47% Nov 13, 2017 - Apr 9, 2018	N/A
#6	-18.79% Mar 12, 2007 - Jun 19, 2007	N/A
#7	-9.16% Jun 25, 2007 - Jul 3, 2007	N/A
#8	-8.75% Dec 3, 2004 - Mar 28, 2005	N/A
#9	-5.73% Feb 21, 2007 - Mar 7, 2007	N/A
#10	-5.34% Dec 8, 2020 - Dec 16, 2020	N/A
#11	-4.94% Mar 28, 2005 - May 11, 2005	N/A
#12	-4.48% Dec 17, 2020 - Dec 21, 2020	N/A
#13	-4.01% Jul 9, 2007 - Jul 13, 2007	N/A
#14	-2.82% Nov 22, 2004 - Nov 24, 2004	N/A
#15	-2.50% Nov 24, 2004 - Dec 1, 2004	N/A

Correlation

Correlation between SPRO and AMBI is -0.50 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.50

-101