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SPRO vs SPY

Comparison between Spero Therapeutics Inc (SPRO, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).

5-Year PerformanceSPY has outperformed SPRO, delivering a return of +13.4% compared to -28.6%

SPRO vs SPY - Performance Comparison

Key Characteristics

Financial metrics and valuation ratios

Market Cap / Net Assets
SPRO
$147M
Winner
SPY
$784B
Expense Ratio
SPRO
N/A
SPY
0.09%
Max Drawdown
SPRO
97.46%
Winner
SPY
56.47%
Sharpe Ratio
SPRO
0.09
Winner
SPY
1.50
5Y Beta
Winner
SPRO
0.60
SPY
1.00
Industry
SPRO
Biotechnology
SPY
N/A
P/E Ratio
Winner
SPRO
9.31
SPY
28.29
Forward P/E
SPRO
N/A
SPY
21.76
PEG Ratio
SPRO
0.00
SPY
N/A
5Y Dividends CAGR
Winner
SPRO
30.26%
SPY
5.43%
5Y EPS CAGR
SPRO
N/A
SPY
25.98%
Debt to Equity
Winner
SPRO
0.00%
SPY
30.79%
Free Cash Flow Yield
SPRO
4.93%
SPY
N/A
P/S Ratio
Winner
SPRO
2.42
SPY
3.79
P/B Ratio
Winner
SPRO
2.81
SPY
5.67

SPRO vs SPY - Historical Returns

Returns include dividend reinvestment.

1M
Winner
SPRO
+12.20%
SPY
+0.48%
3M
SPRO
+10.04%
Winner
SPY
+11.67%
6M
Winner
SPRO
+22.84%
SPY
+9.42%
1Y
SPRO
-1.38%
Winner
SPY
+24.27%
5Y(CAGR)
SPRO
-28.65%
Winner
SPY
+13.36%
10Y(CAGR)
SPRO
-2.10%
Winner
SPY
+15.42%
Max(CAGR)
SPRO
-0.31%
Winner
SPY
+8.49%

SPRO vs SPY - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

YearSPROSPY
2026+21.28%+8.88%
2025+115.74%+18.00%
2024-32.24%+25.59%
2023-15.52%+26.72%
2022-88.58%-18.64%
2021-10.71%+30.52%
2020+96.45%+17.28%
2019+53.59%+31.09%
2018-49.34%-5.24%
2017+2.17%+20.78%
2016N/A+13.59%
2015+125.03%+1.31%
2014-36.85%+14.56%
2013+87.73%+29.00%
2012-15.94%+14.17%
2011-18.88%+0.85%
2010-29.17%+13.14%
2009+37.55%+22.67%
2008-59.66%-36.25%
2007+44.06%+5.32%
2006+26.56%+13.85%
2005-15.34%+5.32%
2004+7.04%+10.75%
2003N/A+24.18%
2002N/A-22.42%
2001N/A-10.13%
2000N/A-8.84%
1999N/A+8.61%

SPRO vs SPY Drawdown Comparison

The maximum drawdown for SPRO was -97.46%, occurring on Apr 8, 2025. This drawdown has not yet recovered.

The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.

The current SPRO drawdown is -87.09%. The current SPY drawdown is -2.35%.

RankSPROSPY
#1-97.46%
Dec 28, 2020 - Apr 8, 2025		-55.20%
Oct 9, 2007 - Aug 16, 2012
#2-85.13%
Jul 17, 2007 - Nov 2, 2017		-47.50%
Mar 24, 2000 - Oct 26, 2006
#3-70.48%
Apr 12, 2018 - Dec 8, 2020		-33.70%
Feb 19, 2020 - Aug 10, 2020
#4-42.56%
May 17, 2005 - Feb 16, 2007		-24.50%
Jan 3, 2022 - Dec 13, 2023
#5-32.47%
Nov 13, 2017 - Apr 9, 2018		-19.34%
Sep 20, 2018 - Apr 12, 2019
#6-18.79%
Mar 12, 2007 - Jun 19, 2007		-18.76%
Feb 19, 2025 - Jun 26, 2025
#7-9.16%
Jun 25, 2007 - Jul 3, 2007		-13.02%
Jul 20, 2015 - Apr 18, 2016
#8-8.75%
Dec 3, 2004 - Mar 28, 2005		-10.10%
Jan 26, 2018 - Aug 6, 2018
#9-5.73%
Feb 21, 2007 - Mar 7, 2007		-9.44%
Sep 2, 2020 - Nov 11, 2020
#10-5.34%
Dec 8, 2020 - Dec 16, 2020		-9.30%
Jan 19, 2000 - Mar 17, 2000
#11-4.94%
Mar 28, 2005 - May 11, 2005		-9.05%
Jul 19, 2007 - Oct 5, 2007
#12-4.48%
Dec 17, 2020 - Dec 21, 2020		-8.88%
Jan 27, 2026 - Apr 14, 2026
#13-4.01%
Jul 9, 2007 - Jul 13, 2007		-8.41%
Jul 16, 2024 - Sep 19, 2024
#14-2.82%
Nov 22, 2004 - Nov 24, 2004		-7.35%
Sep 14, 2012 - Jan 2, 2013
#15-2.50%
Nov 24, 2004 - Dec 1, 2004		-7.27%
Sep 18, 2014 - Oct 31, 2014

Correlation

Correlation between SPRO and SPY is 0.14 which considered as a very weak or no correlation - the stocks move independently of each other.

0.14
-101

Dividend Comparison (1999 - 2026)

SPRO vs SPY dividend yield comparison.

YearSPROSPY
20260.00%0.24%
20250.00%1.07%
20240.00%1.21%
20230.00%1.40%
20220.00%1.65%
20210.00%1.20%
20200.00%1.52%
20190.00%1.75%
20180.00%2.04%
20170.00%1.80%
20160.00%2.03%
20151.26%2.06%
20143.77%1.87%
20132.41%1.81%
20123.40%2.18%
20112.67%2.05%
20101.67%1.80%
20090.00%1.95%
20080.00%3.02%
20070.00%1.85%
20060.00%1.73%
20050.00%1.73%
20040.00%1.82%
20030.00%1.47%
20020.00%1.70%
20010.00%1.25%
20000.00%1.15%
19990.00%0.24%

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