RYTM vs LSTR

Comparison between Rhythm Pharmaceuticals Inc (RYTM, Company) and Landstar System Inc (LSTR, Company).

RYTM is from the Healthcare sector, while LSTR is from the Industrials sector.

5-Year PerformanceRYTM has outperformed LSTR, delivering a return of +38.7% compared to +8.5%

RYTM vs LSTR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	RYTM(COMPANY)	LSTR(COMPANY)
Market Cap	$7.12B	$7.15B
Max Drawdown	92.10%	53.35%
Sharpe Ratio	0.49	1.34
5Y Beta	0.88	0.73
Industry	Biotechnology	Integrated Freight & Logistics
P/E Ratio	-34.17	55.76
Forward P/E	N/A	38.17
PEG Ratio	-2.81	1.57
Dividend Yield	N/A	0.75%
5Y Dividends CAGR	N/A	7.09%
5Y EPS CAGR	17.00%	-9.61%
Debt to Equity	88.25%	0.00%
Free Cash Flow Yield	-1.69%	3.27%
P/S Ratio	32.84	1.49
P/B Ratio	59.49	9.09

Market Cap

RYTM

$7.12B

Winner

LSTR

$7.15B

Max Drawdown

RYTM

92.10%

Winner

LSTR

53.35%

Sharpe Ratio

RYTM

0.49

Winner

LSTR

1.34

5Y Beta

RYTM

0.88

Winner

LSTR

0.73

Industry

RYTM

Biotechnology

LSTR

Integrated Freight & Logistics

P/E Ratio

Winner

RYTM

-34.17

LSTR

55.76

Forward P/E

RYTM

N/A

LSTR

38.17

PEG Ratio

Winner

RYTM

-2.81

LSTR

1.57

Dividend Yield

RYTM

N/A

LSTR

0.75%

5Y Dividends CAGR

RYTM

N/A

LSTR

7.09%

5Y EPS CAGR

Winner

RYTM

17.00%

LSTR

-9.61%

Debt to Equity

RYTM

88.25%

Winner

LSTR

0.00%

Free Cash Flow Yield

RYTM

-1.69%

Winner

LSTR

3.27%

P/S Ratio

RYTM

32.84

Winner

LSTR

1.49

P/B Ratio

RYTM

59.49

Winner

LSTR

9.09

RYTM vs LSTR - Historical Returns

Returns include dividend reinvestment.

Period	RYTM	LSTR
1 month	-3.32%	+0.23%
3 months	+20.48%	+15.86%
6 months	-0.20%	+35.76%
1 year	+16.91%	+53.97%
5 years(CAGR)	+38.68%	+8.55%
10 years(CAGR)	+15.01%	+13.42%
Max(CAGR)	+15.01%	+15.92%

RYTM

-3.32%

Winner

LSTR

+0.23%

Winner

RYTM

+20.48%

LSTR

+15.86%

RYTM

-0.20%

Winner

LSTR

+35.76%

RYTM

+16.91%

Winner

LSTR

+53.97%

5Y(CAGR)

Winner

RYTM

+38.68%

LSTR

+8.55%

10Y(CAGR)

Winner

RYTM

+15.01%

LSTR

+13.42%

Max(CAGR)

RYTM

+15.01%

Winner

LSTR

+15.92%

RYTM vs LSTR - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	RYTM	LSTR
2026	-2.24%	+44.30%
2025	+78.19%	-13.66%
2024	+24.04%	-8.59%
2023	+60.51%	+20.61%
2022	+172.91%	-6.83%
2021	-67.13%	+37.14%
2020	+29.83%	+21.63%
2019	-15.71%	+18.51%
2018	-4.00%	-6.64%
2017	-3.13%	+22.00%
2016	N/A	+46.33%
2015	N/A	-17.08%
2014	N/A	+27.98%
2013	N/A	+8.10%
2012	N/A	+12.22%
2011	N/A	+16.61%
2010	N/A	+4.84%
2009	N/A	-2.45%
2008	N/A	-6.97%
2007	N/A	+5.49%
2006	N/A	-8.43%
2005	N/A	+11.50%
2004	N/A	+95.28%
2003	N/A	+30.07%
2002	N/A	+62.00%
2001	N/A	+29.48%
2000	N/A	+38.81%
1999	N/A	+4.42%

RYTM vs LSTR Drawdown Comparison

The maximum drawdown for RYTM was -92.10%, occurring on May 19, 2022. Recovery took 727 trading sessions.

The maximum drawdown for LSTR was -53.20%, occurring on Mar 9, 2009. Recovery took 942 trading sessions.

The current RYTM drawdown is -12.72%. The current LSTR drawdown is -7.72%.

Rank	RYTM	LSTR
#1	-92.10% Jan 22, 2021 - Dec 12, 2023	-53.20% Jun 19, 2008 - Mar 15, 2012
#2	-63.29% Jul 5, 2018 - Jan 21, 2021	-44.34% Apr 12, 2000 - Feb 12, 2001
#3	-47.22% Jan 29, 2018 - Jun 1, 2018	-38.75% Jul 26, 2023 - May 22, 2026
#4	-35.54% Dec 11, 2025 - Mar 27, 2026	-31.03% Nov 28, 2014 - Nov 10, 2016
#5	-32.48% Feb 12, 2024 - Jul 16, 2024	-30.13% Sep 11, 2018 - Jul 29, 2020
#6	-30.27% Nov 8, 2024 - Jun 6, 2025	-28.21% May 23, 2007 - Mar 20, 2008
#7	-26.67% Oct 5, 2017 - Dec 1, 2017	-28.02% Mar 7, 2005 - Sep 16, 2005
#8	-24.99% Jun 6, 2018 - Jun 26, 2018	-24.33% Nov 4, 2021 - Feb 2, 2023
#9	-19.92% Dec 27, 2023 - Feb 9, 2024	-23.45% Jul 17, 2001 - Jan 23, 2002
#10	-19.17% Jul 16, 2024 - Sep 19, 2024	-22.52% Jul 3, 2006 - Apr 19, 2007
#11	-15.80% Oct 29, 2025 - Dec 11, 2025	-20.01% Apr 3, 2012 - Jan 22, 2013
#12	-13.83% Dec 18, 2017 - Jan 25, 2018	-18.42% Jun 17, 2002 - Aug 16, 2002
#13	-13.47% Sep 19, 2024 - Nov 5, 2024	-18.23% Feb 9, 2000 - Apr 12, 2000
#14	-11.19% Jun 26, 2018 - Jul 3, 2018	-18.18% Oct 15, 2002 - Dec 19, 2002
#15	-10.68% Dec 1, 2017 - Dec 18, 2017	-17.91% Dec 8, 1999 - Jan 10, 2000