RYTM vs MSM

Comparison between Rhythm Pharmaceuticals Inc (RYTM, Company) and MSC Industrial Direct Co. Inc - Class A (MSM, Company).

RYTM is from the Healthcare sector, while MSM is from the Industrials sector.

5-Year PerformanceRYTM has outperformed MSM, delivering a return of +36.4% compared to +10.4%

RYTM vs MSM - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	RYTM(COMPANY)	MSM(COMPANY)
Market Cap	$6.62B	$6.61B
Max Drawdown	92.10%	57.07%
Sharpe Ratio	0.98	1.53
5Y Beta	0.92	0.82
Industry	Biotechnology	Industrial Distribution
P/E Ratio	-31.81	34.70
Forward P/E	N/A	22.32
PEG Ratio	-2.61	N/A
Dividend Yield	N/A	2.95%
5Y Dividends CAGR	N/A	-7.89%
5Y EPS CAGR	17.00%	-8.84%
Debt to Equity	88.25%	0.00%
Free Cash Flow Yield	-1.82%	3.25%

Market Cap

Winner

RYTM

$6.62B

MSM

$6.61B

Max Drawdown

RYTM

92.10%

Winner

MSM

57.07%

Sharpe Ratio

RYTM

0.98

Winner

MSM

1.53

5Y Beta

RYTM

0.92

Winner

MSM

0.82

Industry

RYTM

Biotechnology

MSM

Industrial Distribution

P/E Ratio

Winner

RYTM

-31.81

MSM

34.70

Forward P/E

RYTM

N/A

MSM

22.32

PEG Ratio

RYTM

-2.61

MSM

N/A

Dividend Yield

RYTM

N/A

MSM

2.95%

5Y Dividends CAGR

RYTM

N/A

MSM

-7.89%

5Y EPS CAGR

Winner

RYTM

17.00%

MSM

-8.84%

Debt to Equity

RYTM

88.25%

Winner

MSM

0.00%

Free Cash Flow Yield

RYTM

-1.82%

Winner

MSM

3.25%

RYTM vs MSM - Historical Returns

Returns include dividend reinvestment.

Period	RYTM	MSM
1 month	+11.46%	+13.23%
3 months	+12.73%	+35.99%
6 months	-13.37%	+40.08%
1 year	+57.43%	+50.00%
5 years(CAGR)	+36.39%	+10.36%
10 years(CAGR)	+14.41%	+9.93%
Max(CAGR)	+14.41%	+12.61%

RYTM

+11.46%

Winner

MSM

+13.23%

RYTM

+12.73%

Winner

MSM

+35.99%

RYTM

-13.37%

Winner

MSM

+40.08%

Winner

RYTM

+57.43%

MSM

+50.00%

5Y(CAGR)

Winner

RYTM

+36.39%

MSM

+10.36%

10Y(CAGR)

Winner

RYTM

+14.41%

MSM

+9.93%

Max(CAGR)

Winner

RYTM

+14.41%

MSM

+12.61%

RYTM vs MSM - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	RYTM	MSM
2026	-7.83%	+40.75%
2025	+78.19%	+16.42%
2024	+24.04%	-22.03%
2023	+60.51%	+28.51%
2022	+172.91%	+1.01%
2021	-67.13%	+6.52%
2020	+29.83%	+24.83%
2019	-15.71%	+7.25%
2018	-4.00%	-18.73%
2017	-3.13%	+6.92%
2016	N/A	+67.44%
2015	N/A	-29.09%
2014	N/A	+6.04%
2013	N/A	+6.29%
2012	N/A	+7.44%
2011	N/A	+10.56%
2010	N/A	+40.74%
2009	N/A	+23.47%
2008	N/A	-5.08%
2007	N/A	+1.39%
2006	N/A	-4.62%
2005	N/A	+20.64%
2004	N/A	+31.97%
2003	N/A	+53.88%
2002	N/A	-7.79%
2001	N/A	+15.36%
2000	N/A	+33.78%
1999	N/A	+23.95%

RYTM vs MSM Drawdown Comparison

The maximum drawdown for RYTM was -92.10%, occurring on May 19, 2022. Recovery took 727 trading sessions.

The maximum drawdown for MSM was -57.07%, occurring on Sep 23, 2002. Recovery took 410 trading sessions.

The current RYTM drawdown is -17.71%.

Rank	RYTM	MSM
#1	-92.10% Jan 22, 2021 - Dec 12, 2023	-57.07% Mar 20, 2002 - Nov 3, 2003
#2	-63.29% Jul 5, 2018 - Jan 21, 2021	-50.77% Jul 9, 2007 - Apr 7, 2010
#3	-47.22% Jan 29, 2018 - Jun 1, 2018	-48.19% Feb 21, 2017 - Nov 24, 2020
#4	-35.54% Dec 11, 2025 - Mar 27, 2026	-47.44% May 31, 2000 - Mar 4, 2002
#5	-32.48% Feb 12, 2024 - Jul 16, 2024	-38.74% Jun 11, 2014 - Nov 23, 2016
#6	-30.27% Nov 8, 2024 - Jun 6, 2025	-32.73% Apr 6, 2011 - Jan 13, 2012
#7	-26.67% Oct 5, 2017 - Dec 1, 2017	-31.14% May 9, 2006 - Jun 1, 2007
#8	-24.99% Jun 6, 2018 - Jun 26, 2018	-30.83% Jan 20, 2000 - May 11, 2000
#9	-19.92% Dec 27, 2023 - Feb 9, 2024	-29.28% Oct 12, 2023 - Feb 6, 2026
#10	-19.17% Jul 16, 2024 - Sep 19, 2024	-26.06% Nov 29, 2004 - Jul 28, 2005
#11	-15.80% Oct 29, 2025 - Dec 11, 2025	-26.03% Mar 28, 2012 - Feb 12, 2013
#12	-13.83% Dec 18, 2017 - Jan 25, 2018	-23.27% Nov 2, 1999 - Dec 8, 1999
#13	-13.47% Sep 19, 2024 - Nov 5, 2024	-21.82% Apr 7, 2010 - Oct 21, 2010
#14	-11.19% Jun 26, 2018 - Jul 3, 2018	-21.27% May 14, 2021 - Apr 17, 2023
#15	-10.68% Dec 1, 2017 - Dec 18, 2017	-15.81% Jul 15, 2004 - Sep 29, 2004