RGEN vs IONS

Comparison between Repligen Corp (RGEN, Company) and Ionis Pharmaceuticals Inc (IONS, Company).

Both RGEN and IONS are from the Healthcare sector.

5-Year PerformanceIONS has outperformed RGEN, delivering a return of +7.8% compared to -8.1%

RGEN vs IONS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	RGEN(COMPANY)	IONS(COMPANY)
Market Cap	$8.95B	$8.98B
Max Drawdown	92.06%	91.72%
Sharpe Ratio	0.96	0.81
5Y Beta	1.35	0.66
Industry	Medical Instruments & Supplies	Biotechnology
P/E Ratio	215.09	-21.49
Forward P/E	72.99	96.15
PEG Ratio	3.54	27.33
5Y EPS CAGR	-2.47%	-8.41%
Debt to Equity	26.09%	0.00%
Free Cash Flow Yield	1.25%	-6.25%
P/S Ratio	11.40	10.30
P/B Ratio	4.00	20.81

Market Cap

RGEN

$8.95B

Winner

IONS

$8.98B

Max Drawdown

RGEN

92.06%

Winner

IONS

91.72%

Sharpe Ratio

Winner

RGEN

0.96

IONS

0.81

5Y Beta

RGEN

1.35

Winner

IONS

0.66

Industry

RGEN

Medical Instruments & Supplies

IONS

Biotechnology

P/E Ratio

RGEN

215.09

Winner

IONS

-21.49

Forward P/E

Winner

RGEN

72.99

IONS

96.15

PEG Ratio

Winner

RGEN

3.54

IONS

27.33

5Y EPS CAGR

Winner

RGEN

-2.47%

IONS

-8.41%

Debt to Equity

RGEN

26.09%

Winner

IONS

0.00%

Free Cash Flow Yield

Winner

RGEN

1.25%

IONS

-6.25%

P/S Ratio

RGEN

11.40

Winner

IONS

10.30

P/B Ratio

Winner

RGEN

4.00

IONS

20.81

RGEN vs IONS - Historical Returns

Returns include dividend reinvestment.

Period	RGEN	IONS
1 month	+17.21%	-34.48%
3 months	+29.64%	-25.60%
6 months	+15.28%	-34.61%
1 year	+44.38%	+37.78%
5 years(CAGR)	-8.14%	+7.83%
10 years(CAGR)	+18.52%	+4.65%
Max(CAGR)	+15.86%	+6.40%

Winner

RGEN

+17.21%

IONS

-34.48%

Winner

RGEN

+29.64%

IONS

-25.60%

Winner

RGEN

+15.28%

IONS

-34.61%

Winner

RGEN

+44.38%

IONS

+37.78%

5Y(CAGR)

RGEN

-8.14%

Winner

IONS

+7.83%

10Y(CAGR)

Winner

RGEN

+18.52%

IONS

+4.65%

Max(CAGR)

Winner

RGEN

+15.86%

IONS

+6.40%

RGEN vs IONS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	RGEN	IONS
2026	-0.27%	-29.01%
2025	+14.55%	+128.05%
2024	-19.72%	-33.88%
2023	+10.99%	+34.62%
2022	-34.37%	+15.86%
2021	+38.91%	-46.41%
2020	+104.34%	-7.14%
2019	+78.95%	+12.35%
2018	+42.31%	+9.77%
2017	+16.47%	+6.25%
2016	+9.68%	-22.45%
2015	+40.75%	+0.58%
2014	+56.77%	+54.85%
2013	+105.73%	+268.21%
2012	+79.43%	+44.00%
2011	-23.23%	-29.93%
2010	+16.09%	-10.20%
2009	+4.85%	-23.22%
2008	-43.16%	-7.80%
2007	+133.93%	+44.10%
2006	-27.95%	+111.81%
2005	+37.93%	-9.66%
2004	-30.77%	-13.36%
2003	+47.14%	-4.97%
2002	+13.01%	-68.69%
2001	-31.63%	+130.55%
2000	+10.19%	+77.49%
1999	-1.98%	-44.34%

RGEN vs IONS Drawdown Comparison

The maximum drawdown for RGEN was -92.06%, occurring on Jul 23, 2004. Recovery took 3565 trading sessions.

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The current RGEN drawdown is -49.45%. The current IONS drawdown is -34.61%.

Rank	RGEN	IONS
#1	-92.06% Mar 3, 2000 - May 7, 2014	-91.43% Mar 6, 2000 - Jul 11, 2013
#2	-68.27% Sep 23, 2021 - May 15, 2026	-73.25% Mar 19, 2015 - Mar 14, 2019
#3	-50.33% Jul 7, 2015 - Jun 23, 2017	-70.39% Apr 8, 2019 - Feb 6, 2026
#4	-39.47% Nov 18, 1999 - Jan 24, 2000	-68.14% Dec 2, 1999 - Mar 1, 2000
#5	-32.87% Sep 18, 2017 - Jun 22, 2018	-61.05% Feb 21, 2014 - Dec 10, 2014
#6	-29.94% Nov 8, 2018 - Apr 26, 2019	-40.15% Feb 6, 2026 - Jul 31, 2026
#7	-26.69% Feb 12, 2021 - Jul 27, 2021	-28.35% Jul 12, 2013 - Sep 19, 2013
#8	-26.06% Feb 18, 2000 - Mar 1, 2000	-20.89% Sep 23, 2013 - Nov 27, 2013
#9	-24.16% Jul 14, 2014 - Oct 28, 2014	-19.78% Jan 12, 2015 - Mar 19, 2015
#10	-23.73% Oct 30, 2014 - Jan 16, 2015	-11.84% Dec 12, 2014 - Dec 19, 2014
#11	-22.69% Aug 1, 2019 - Jan 9, 2020	-11.49% Dec 19, 2014 - Jan 5, 2015
#12	-22.16% Feb 19, 2020 - Apr 22, 2020	-8.95% Jan 31, 2014 - Feb 13, 2014
#13	-19.46% May 15, 2020 - Jul 30, 2020	-8.58% Nov 11, 1999 - Nov 17, 1999
#14	-17.65% Feb 10, 2000 - Feb 15, 2000	-7.67% Jan 22, 2014 - Jan 31, 2014
#15	-15.69% Jan 19, 2021 - Feb 11, 2021	-7.49% Dec 23, 2013 - Jan 8, 2014