IONS vs SPY
Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).
5-Year PerformanceIONS has outperformed SPY, delivering a return of +15.7% compared to +13.3%
IONS vs SPY - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
IONS vs SPY - Historical Returns
Returns include dividend reinvestment.
IONS vs SPY - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | IONS | SPY |
|---|---|---|
| 2026 | -4.97% | +8.27% |
| 2025 | +128.05% | +18.00% |
| 2024 | -33.88% | +25.59% |
| 2023 | +34.62% | +26.72% |
| 2022 | +15.86% | -18.64% |
| 2021 | -46.41% | +30.52% |
| 2020 | -7.14% | +17.28% |
| 2019 | +12.35% | +31.09% |
| 2018 | +9.77% | -5.24% |
| 2017 | +6.25% | +20.78% |
| 2016 | -22.45% | +13.59% |
| 2015 | +0.58% | +1.31% |
| 2014 | +54.85% | +14.56% |
| 2013 | +268.21% | +29.00% |
| 2012 | +44.00% | +14.17% |
| 2011 | -29.93% | +0.85% |
| 2010 | -10.20% | +13.14% |
| 2009 | -23.22% | +22.67% |
| 2008 | -7.80% | -36.25% |
| 2007 | +44.10% | +5.32% |
| 2006 | +111.81% | +13.85% |
| 2005 | -9.66% | +5.32% |
| 2004 | -13.36% | +10.75% |
| 2003 | -4.97% | +24.18% |
| 2002 | -68.69% | -22.42% |
| 2001 | +130.55% | -10.13% |
| 2000 | +77.49% | -8.84% |
| 1999 | -44.34% | +8.61% |
IONS vs SPY Drawdown Comparison
The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.
The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.
The current IONS drawdown is -12.47%.
| Rank | IONS | SPY |
|---|---|---|
| #1 | -91.43% Mar 6, 2000 - Jul 11, 2013 | -55.20% Oct 9, 2007 - Aug 16, 2012 |
| #2 | -73.25% Mar 19, 2015 - Mar 14, 2019 | -47.50% Mar 24, 2000 - Oct 26, 2006 |
| #3 | -70.39% Apr 8, 2019 - Feb 6, 2026 | -33.70% Feb 19, 2020 - Aug 10, 2020 |
| #4 | -68.14% Dec 2, 1999 - Mar 1, 2000 | -24.50% Jan 3, 2022 - Dec 13, 2023 |
| #5 | -61.05% Feb 21, 2014 - Dec 10, 2014 | -19.34% Sep 20, 2018 - Apr 12, 2019 |
| #6 | -28.35% Jul 12, 2013 - Sep 19, 2013 | -18.76% Feb 19, 2025 - Jun 26, 2025 |
| #7 | -20.89% Sep 23, 2013 - Nov 27, 2013 | -13.02% Jul 20, 2015 - Apr 18, 2016 |
| #8 | -19.78% Jan 12, 2015 - Mar 19, 2015 | -10.10% Jan 26, 2018 - Aug 6, 2018 |
| #9 | -19.45% Feb 6, 2026 - Mar 24, 2026 | -9.44% Sep 2, 2020 - Nov 11, 2020 |
| #10 | -11.84% Dec 12, 2014 - Dec 19, 2014 | -9.30% Jan 19, 2000 - Mar 17, 2000 |
| #11 | -11.49% Dec 19, 2014 - Jan 5, 2015 | -9.05% Jul 19, 2007 - Oct 5, 2007 |
| #12 | -8.95% Jan 31, 2014 - Feb 13, 2014 | -8.88% Jan 27, 2026 - Apr 14, 2026 |
| #13 | -8.58% Nov 11, 1999 - Nov 17, 1999 | -8.41% Jul 16, 2024 - Sep 19, 2024 |
| #14 | -7.67% Jan 22, 2014 - Jan 31, 2014 | -7.35% Sep 14, 2012 - Jan 2, 2013 |
| #15 | -7.49% Dec 23, 2013 - Jan 8, 2014 | -7.27% Sep 18, 2014 - Oct 31, 2014 |
Correlation
Correlation between IONS and SPY is 0.70 which considered as a moderate positive correlation - the stocks show some tendency to move together.
Dividend Comparison (1999 - 2026)
IONS vs SPY dividend yield comparison.
| Year | IONS | SPY |
|---|---|---|
| 2026 | 0.00% | 0.24% |
| 2025 | 0.00% | 1.07% |
| 2024 | 0.00% | 1.21% |
| 2023 | 0.00% | 1.40% |
| 2022 | 0.00% | 1.65% |
| 2021 | 0.00% | 1.20% |
| 2020 | 0.00% | 1.52% |
| 2019 | 0.00% | 1.75% |
| 2018 | 0.00% | 2.04% |
| 2017 | 0.00% | 1.80% |
| 2016 | 0.00% | 2.03% |
| 2015 | 0.00% | 2.06% |
| 2014 | 0.00% | 1.87% |
| 2013 | 0.00% | 1.81% |
| 2012 | 0.00% | 2.18% |
| 2011 | 0.00% | 2.05% |
| 2010 | 0.00% | 1.80% |
| 2009 | 0.00% | 1.95% |
| 2008 | 0.00% | 3.02% |
| 2007 | 0.00% | 1.85% |
| 2006 | 0.00% | 1.73% |
| 2005 | 0.00% | 1.73% |
| 2004 | 0.00% | 1.82% |
| 2003 | 0.00% | 1.47% |
| 2002 | 0.00% | 1.70% |
| 2001 | 0.00% | 1.25% |
| 2000 | 4.85% | 1.15% |
| 1999 | 3.52% | 0.24% |
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