IONS vs RGEN

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Repligen Corp (RGEN, Company).

Both IONS and RGEN are from the Healthcare sector.

5-Year PerformanceIONS has outperformed RGEN, delivering a return of +7.8% compared to -8.1%

IONS vs RGEN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	RGEN(COMPANY)
Market Cap	$8.98B	$8.95B
Max Drawdown	91.72%	92.06%
Sharpe Ratio	0.81	0.96
5Y Beta	0.66	1.35
Industry	Biotechnology	Medical Instruments & Supplies
P/E Ratio	-21.49	215.09
Forward P/E	96.15	72.99
PEG Ratio	27.33	3.54
5Y EPS CAGR	-8.41%	-2.47%
Debt to Equity	0.00%	26.09%
Free Cash Flow Yield	-6.25%	1.25%
P/S Ratio	10.30	11.40
P/B Ratio	20.81	4.00

Market Cap

Winner

IONS

$8.98B

RGEN

$8.95B

Max Drawdown

Winner

IONS

91.72%

RGEN

92.06%

Sharpe Ratio

IONS

0.81

Winner

RGEN

0.96

5Y Beta

Winner

IONS

0.66

RGEN

1.35

Industry

IONS

Biotechnology

RGEN

Medical Instruments & Supplies

P/E Ratio

Winner

IONS

-21.49

RGEN

215.09

Forward P/E

IONS

96.15

Winner

RGEN

72.99

PEG Ratio

IONS

27.33

Winner

RGEN

3.54

5Y EPS CAGR

IONS

-8.41%

Winner

RGEN

-2.47%

Debt to Equity

Winner

IONS

0.00%

RGEN

26.09%

Free Cash Flow Yield

IONS

-6.25%

Winner

RGEN

1.25%

P/S Ratio

Winner

IONS

10.30

RGEN

11.40

P/B Ratio

IONS

20.81

Winner

RGEN

4.00

IONS vs RGEN - Historical Returns

Returns include dividend reinvestment.

Period	IONS	RGEN
1 month	-34.48%	+17.21%
3 months	-25.60%	+29.64%
6 months	-34.61%	+15.28%
1 year	+37.78%	+44.38%
5 years(CAGR)	+7.83%	-8.14%
10 years(CAGR)	+4.65%	+18.52%
Max(CAGR)	+6.40%	+15.86%

IONS

-34.48%

Winner

RGEN

+17.21%

IONS

-25.60%

Winner

RGEN

+29.64%

IONS

-34.61%

Winner

RGEN

+15.28%

IONS

+37.78%

Winner

RGEN

+44.38%

5Y(CAGR)

Winner

IONS

+7.83%

RGEN

-8.14%

10Y(CAGR)

IONS

+4.65%

Winner

RGEN

+18.52%

Max(CAGR)

IONS

+6.40%

Winner

RGEN

+15.86%

IONS vs RGEN - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	RGEN
2026	-29.01%	-0.27%
2025	+128.05%	+14.55%
2024	-33.88%	-19.72%
2023	+34.62%	+10.99%
2022	+15.86%	-34.37%
2021	-46.41%	+38.91%
2020	-7.14%	+104.34%
2019	+12.35%	+78.95%
2018	+9.77%	+42.31%
2017	+6.25%	+16.47%
2016	-22.45%	+9.68%
2015	+0.58%	+40.75%
2014	+54.85%	+56.77%
2013	+268.21%	+105.73%
2012	+44.00%	+79.43%
2011	-29.93%	-23.23%
2010	-10.20%	+16.09%
2009	-23.22%	+4.85%
2008	-7.80%	-43.16%
2007	+44.10%	+133.93%
2006	+111.81%	-27.95%
2005	-9.66%	+37.93%
2004	-13.36%	-30.77%
2003	-4.97%	+47.14%
2002	-68.69%	+13.01%
2001	+130.55%	-31.63%
2000	+77.49%	+10.19%
1999	-44.34%	-1.98%

IONS vs RGEN Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for RGEN was -92.06%, occurring on Jul 23, 2004. Recovery took 3565 trading sessions.

The current IONS drawdown is -34.61%. The current RGEN drawdown is -49.45%.

Rank	IONS	RGEN
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-92.06% Mar 3, 2000 - May 7, 2014
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-68.27% Sep 23, 2021 - May 15, 2026
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-50.33% Jul 7, 2015 - Jun 23, 2017
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-39.47% Nov 18, 1999 - Jan 24, 2000
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-32.87% Sep 18, 2017 - Jun 22, 2018
#6	-40.15% Feb 6, 2026 - Jul 31, 2026	-29.94% Nov 8, 2018 - Apr 26, 2019
#7	-28.35% Jul 12, 2013 - Sep 19, 2013	-26.69% Feb 12, 2021 - Jul 27, 2021
#8	-20.89% Sep 23, 2013 - Nov 27, 2013	-26.06% Feb 18, 2000 - Mar 1, 2000
#9	-19.78% Jan 12, 2015 - Mar 19, 2015	-24.16% Jul 14, 2014 - Oct 28, 2014
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-23.73% Oct 30, 2014 - Jan 16, 2015
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-22.69% Aug 1, 2019 - Jan 9, 2020
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-22.16% Feb 19, 2020 - Apr 22, 2020
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-19.46% May 15, 2020 - Jul 30, 2020
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-17.65% Feb 10, 2000 - Feb 15, 2000
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-15.69% Jan 19, 2021 - Feb 11, 2021