IONS vs WAL

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Western Alliance Bancorp (WAL, Company).

IONS is from the Healthcare sector, while WAL is from the Financial Services sector.

5-Year PerformanceIONS has outperformed WAL, delivering a return of +7.8% compared to -2.0%

IONS vs WAL - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	WAL(COMPANY)
Market Cap	$8.98B	$8.95B
Max Drawdown	91.72%	92.14%
Sharpe Ratio	0.81	0.26
5Y Beta	0.66	1.45
Industry	Biotechnology	Banks - Regional
P/E Ratio	-21.49	9.71
Forward P/E	96.15	8.42
PEG Ratio	27.33	0.47
Dividend Yield	N/A	2.02%
5Y Dividends CAGR	N/A	10.07%
5Y EPS CAGR	-8.41%	12.09%
Debt to Equity	0.00%	79.52%
Free Cash Flow Yield	-6.25%	-17.11%
P/S Ratio	10.30	2.60
P/B Ratio	20.81	1.22

Market Cap

Winner

IONS

$8.98B

WAL

$8.95B

Max Drawdown

Winner

IONS

91.72%

WAL

92.14%

Sharpe Ratio

Winner

IONS

0.81

WAL

0.26

5Y Beta

Winner

IONS

0.66

WAL

1.45

Industry

IONS

Biotechnology

WAL

Banks - Regional

P/E Ratio

Winner

IONS

-21.49

WAL

9.71

Forward P/E

IONS

96.15

Winner

WAL

8.42

PEG Ratio

IONS

27.33

Winner

WAL

0.47

Dividend Yield

IONS

N/A

WAL

2.02%

5Y Dividends CAGR

IONS

N/A

WAL

10.07%

5Y EPS CAGR

IONS

-8.41%

Winner

WAL

12.09%

Debt to Equity

Winner

IONS

0.00%

WAL

79.52%

Free Cash Flow Yield

Winner

IONS

-6.25%

WAL

-17.11%

P/S Ratio

IONS

10.30

Winner

WAL

2.60

P/B Ratio

IONS

20.81

Winner

WAL

1.22

IONS vs WAL - Historical Returns

Returns include dividend reinvestment.

Period	IONS	WAL
1 month	-34.48%	-0.60%
3 months	-25.60%	-0.64%
6 months	-34.61%	-12.97%
1 year	+37.78%	+6.23%
5 years(CAGR)	+7.83%	-2.02%
10 years(CAGR)	+4.65%	+10.39%
Max(CAGR)	+6.40%	+6.29%

IONS

-34.48%

Winner

WAL

-0.60%

IONS

-25.60%

Winner

WAL

-0.64%

IONS

-34.61%

Winner

WAL

-12.97%

Winner

IONS

+37.78%

WAL

+6.23%

5Y(CAGR)

Winner

IONS

+7.83%

WAL

-2.02%

10Y(CAGR)

IONS

+4.65%

Winner

WAL

+10.39%

Max(CAGR)

Winner

IONS

+6.40%

WAL

+6.29%

IONS vs WAL - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	WAL
2026	-29.01%	-3.89%
2025	+128.05%	+3.36%
2024	-33.88%	+31.83%
2023	+34.62%	+16.17%
2022	+15.86%	-44.64%
2021	-46.41%	+84.52%
2020	-7.14%	+6.36%
2019	+12.35%	+44.41%
2018	+9.77%	-30.56%
2017	+6.25%	+14.78%
2016	-22.45%	+38.66%
2015	+0.58%	+29.69%
2014	+54.85%	+19.11%
2013	+268.21%	+116.71%
2012	+44.00%	+60.52%
2011	-29.93%	-17.92%
2010	-10.20%	+87.28%
2009	-23.22%	-62.65%
2008	-7.80%	-42.01%
2007	+44.10%	-45.34%
2006	+111.81%	+15.29%
2005	-9.66%	+14.88%
2004	-13.36%	N/A
2003	-4.97%	N/A
2002	-68.69%	N/A
2001	+130.55%	N/A
2000	+77.49%	N/A
1999	-44.34%	N/A

IONS vs WAL Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for WAL was -92.14%, occurring on Nov 11, 2009. Recovery took 2337 trading sessions.

The current IONS drawdown is -34.61%. The current WAL drawdown is -26.56%.

Rank	IONS	WAL
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-92.14% Jul 28, 2006 - Nov 9, 2015
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-84.79% Nov 3, 2021 - May 4, 2023
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-64.49% Jun 8, 2018 - Jan 6, 2021
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-29.41% Nov 30, 2015 - Oct 5, 2016
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-20.51% Aug 3, 2005 - Jan 31, 2006
#6	-40.15% Feb 6, 2026 - Jul 31, 2026	-17.26% Apr 27, 2021 - Sep 29, 2021
#7	-28.35% Jul 12, 2013 - Sep 19, 2013	-17.19% Apr 19, 2006 - Jul 28, 2006
#8	-20.89% Sep 23, 2013 - Nov 27, 2013	-15.64% Mar 1, 2017 - Oct 2, 2017
#9	-19.78% Jan 12, 2015 - Mar 19, 2015	-10.50% Mar 9, 2018 - Jun 6, 2018
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-8.18% Mar 19, 2021 - Apr 16, 2021
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-7.06% Oct 10, 2016 - Nov 9, 2016
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-6.37% Oct 22, 2021 - Nov 3, 2021
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-6.25% Feb 24, 2021 - Mar 12, 2021
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-5.89% Dec 8, 2016 - Jan 27, 2017
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-5.87% Jan 14, 2021 - Feb 4, 2021