PTGX vs TGTX

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and TG Therapeutics Inc (TGTX, Company).

Both PTGX and TGTX are from the Healthcare sector.

5-Year PerformancePTGX has outperformed TGTX, delivering a return of +23.6% compared to +8.2%

PTGX vs TGTX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	TGTX(COMPANY)
Market Cap	$8.70B	$8.64B
Max Drawdown	85.79%	99.52%
Sharpe Ratio	1.88	0.94
5Y Beta	0.23	0.80
Industry	Biotechnology	Biotechnology
P/E Ratio	-73.61	18.97
Forward P/E	27.86	42.37
PEG Ratio	0.00	0.02
5Y EPS CAGR	1.43%	N/A
Debt to Equity	0.00%	127.78%
Free Cash Flow Yield	-1.36%	-0.16%
P/S Ratio	113.99	12.00
P/B Ratio	12.89	14.44

Market Cap

Winner

PTGX

$8.70B

TGTX

$8.64B

Max Drawdown

Winner

PTGX

85.79%

TGTX

99.52%

Sharpe Ratio

Winner

PTGX

1.88

TGTX

0.94

5Y Beta

Winner

PTGX

0.23

TGTX

0.80

Industry

PTGX

Biotechnology

TGTX

Biotechnology

P/E Ratio

Winner

PTGX

-73.61

TGTX

18.97

Forward P/E

Winner

PTGX

27.86

TGTX

42.37

PEG Ratio

Winner

PTGX

0.00

TGTX

0.02

5Y EPS CAGR

PTGX

1.43%

TGTX

N/A

Debt to Equity

Winner

PTGX

0.00%

TGTX

127.78%

Free Cash Flow Yield

PTGX

-1.36%

Winner

TGTX

-0.16%

P/S Ratio

PTGX

113.99

Winner

TGTX

12.00

P/B Ratio

Winner

PTGX

12.89

TGTX

14.44

PTGX vs TGTX - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	TGTX
1 month	+19.32%	+8.69%
3 months	+27.27%	+60.15%
6 months	+61.02%	+79.69%
1 year	+133.09%	+41.43%
5 years(CAGR)	+23.57%	+8.21%
10 years(CAGR)	+27.65%	+25.08%
Max(CAGR)	+27.65%	-8.33%

Winner

PTGX

+19.32%

TGTX

+8.69%

PTGX

+27.27%

Winner

TGTX

+60.15%

PTGX

+61.02%

Winner

TGTX

+79.69%

Winner

PTGX

+133.09%

TGTX

+41.43%

5Y(CAGR)

Winner

PTGX

+23.57%

TGTX

+8.21%

10Y(CAGR)

Winner

PTGX

+27.65%

TGTX

+25.08%

Max(CAGR)

Winner

PTGX

+27.65%

TGTX

-8.33%

PTGX vs TGTX - Annual Returns (2010 - 2026)

Returns include dividend reinvestment.

Year	PTGX	TGTX
2026	+51.43%	+87.60%
2025	+124.06%	-4.02%
2024	+64.82%	+76.64%
2023	+112.71%	+47.62%
2022	-69.11%	-42.15%
2021	+74.49%	-62.75%
2020	+190.91%	+375.94%
2019	+2.32%	+157.54%
2018	-68.18%	-53.14%
2017	-1.79%	+84.27%
2016	+87.95%	-59.25%
2015	N/A	-26.94%
2014	N/A	+286.34%
2013	N/A	+5.41%
2012	N/A	+223.56%
2011	N/A	-97.89%
2010	N/A	-77.50%

PTGX vs TGTX Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for TGTX was -99.52%, occurring on Dec 29, 2011. This drawdown has not yet recovered.

The current PTGX drawdown is -6.27%. The current TGTX drawdown is -76.47%.

Rank	PTGX	TGTX
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-99.52% May 4, 2010 - Dec 29, 2011
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	N/A
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	N/A
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	N/A
#5	-19.04% Mar 19, 2021 - May 18, 2021	N/A
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	N/A
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	N/A
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	N/A
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	N/A
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	N/A
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	N/A
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	N/A
#13	-7.78% Jul 7, 2026 - Jul 13, 2026	N/A
#14	-7.43% Mar 31, 2026 - Apr 15, 2026	N/A
#15	-7.20% Jun 14, 2021 - Jun 16, 2021	N/A