PTGX vs ALKS

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Alkermes plc (ALKS, Company).

Both PTGX and ALKS are from the Healthcare sector.

5-Year PerformancePTGX has outperformed ALKS, delivering a return of +23.2% compared to +15.4%

PTGX vs ALKS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	ALKS(COMPANY)
Market Cap	$9B	$9.04B
Max Drawdown	85.79%	96.14%
Sharpe Ratio	1.98	1.42
5Y Beta	0.24	0.61
Industry	Biotechnology	Drug Manufacturers - Specialty & Generic
P/E Ratio	-76.12	58.53
Forward P/E	29.15	142.86
PEG Ratio	0.00	1.96
5Y EPS CAGR	1.43%	N/A
Debt to Equity	0.00%	86.23%
Free Cash Flow Yield	-1.31%	2.45%
P/S Ratio	121.63	5.79
P/B Ratio	13.82	5.19

Market Cap

PTGX

$9B

Winner

ALKS

$9.04B

Max Drawdown

Winner

PTGX

85.79%

ALKS

96.14%

Sharpe Ratio

Winner

PTGX

1.98

ALKS

1.42

5Y Beta

Winner

PTGX

0.24

ALKS

0.61

Industry

PTGX

Biotechnology

ALKS

Drug Manufacturers - Specialty & Generic

P/E Ratio

Winner

PTGX

-76.12

ALKS

58.53

Forward P/E

Winner

PTGX

29.15

ALKS

142.86

PEG Ratio

Winner

PTGX

0.00

ALKS

1.96

5Y EPS CAGR

PTGX

1.43%

ALKS

N/A

Debt to Equity

Winner

PTGX

0.00%

ALKS

86.23%

Free Cash Flow Yield

PTGX

-1.31%

Winner

ALKS

2.45%

P/S Ratio

PTGX

121.63

Winner

ALKS

5.79

P/B Ratio

PTGX

13.82

Winner

ALKS

5.19

PTGX vs ALKS - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	ALKS
1 month	+24.25%	+18.48%
3 months	+32.99%	+55.70%
6 months	+63.82%	+75.12%
1 year	+148.78%	+70.52%
5 years(CAGR)	+23.25%	+15.41%
10 years(CAGR)	+27.64%	+0.55%
Max(CAGR)	+27.64%	+4.00%

Winner

PTGX

+24.25%

ALKS

+18.48%

PTGX

+32.99%

Winner

ALKS

+55.70%

PTGX

+63.82%

Winner

ALKS

+75.12%

Winner

PTGX

+148.78%

ALKS

+70.52%

5Y(CAGR)

Winner

PTGX

+23.25%

ALKS

+15.41%

10Y(CAGR)

Winner

PTGX

+27.64%

ALKS

+0.55%

Max(CAGR)

Winner

PTGX

+27.64%

ALKS

+4.00%

PTGX vs ALKS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	PTGX	ALKS
2026	+50.75%	+83.79%
2025	+124.06%	-2.68%
2024	+64.82%	+0.49%
2023	+112.71%	+7.23%
2022	-69.11%	+8.20%
2021	+74.49%	+17.83%
2020	+190.91%	+0.96%
2019	+2.32%	-29.92%
2018	-68.18%	-46.56%
2017	-1.79%	-2.44%
2016	+87.95%	-25.72%
2015	N/A	+36.30%
2014	N/A	+45.53%
2013	N/A	+110.89%
2012	N/A	+6.81%
2011	N/A	+38.33%
2010	N/A	+26.47%
2009	N/A	-12.14%
2008	N/A	-29.47%
2007	N/A	+19.10%
2006	N/A	-34.84%
2005	N/A	+36.47%
2004	N/A	+0.86%
2003	N/A	+102.70%
2002	N/A	-75.65%
2001	N/A	-4.60%
2000	N/A	+27.74%
1999	N/A	+34.60%

PTGX vs ALKS Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for ALKS was -96.14%, occurring on Jul 11, 2002. This drawdown has not yet recovered.

The current PTGX drawdown is -6.70%. The current ALKS drawdown is -47.03%.

Rank	PTGX	ALKS
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-96.14% Mar 1, 2000 - Jul 11, 2002
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-14.44% Jan 20, 2000 - Feb 3, 2000
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-12.68% Nov 26, 1999 - Dec 17, 1999
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-10.50% Dec 23, 1999 - Jan 7, 2000
#5	-19.04% Mar 19, 2021 - May 18, 2021	-9.45% Feb 18, 2000 - Feb 29, 2000
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-4.37% Nov 11, 1999 - Nov 16, 1999
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-4.12% Feb 11, 2000 - Feb 16, 2000
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-3.50% Jan 10, 2000 - Jan 13, 2000
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-3.33% Feb 8, 2000 - Feb 10, 2000
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-2.86% Nov 16, 1999 - Nov 22, 1999
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	-2.52% Nov 2, 1999 - Nov 5, 1999
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	-2.49% Nov 22, 1999 - Nov 26, 1999
#13	-7.43% Mar 31, 2026 - Apr 15, 2026	-0.62% Nov 9, 1999 - Nov 11, 1999
#14	-7.20% Jun 14, 2021 - Jun 16, 2021	-0.49% Dec 21, 1999 - Dec 23, 1999
#15	-6.70% Jul 7, 2026 - Jul 10, 2026	N/A