PTGX vs AAOI

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Applied Optoelectronics Inc (AAOI, Company).

PTGX is from the Healthcare sector, while AAOI is from the Technology sector.

5-Year PerformanceAAOI has outperformed PTGX, delivering a return of +71.7% compared to +23.2%

PTGX vs AAOI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	AAOI(COMPANY)
Market Cap	$9B	$9.04B
Max Drawdown	85.79%	98.49%
Sharpe Ratio	1.98	1.68
5Y Beta	0.24	3.81
Industry	Biotechnology	Communication Equipment
P/E Ratio	-76.12	-185.08
Forward P/E	29.15	84.03
PEG Ratio	0.00	0.78
5Y EPS CAGR	1.43%	-23.67%
Debt to Equity	0.00%	3.73%
Free Cash Flow Yield	-1.31%	-4.62%
P/S Ratio	121.63	18.11
P/B Ratio	13.82	8.78

Market Cap

PTGX

$9B

Winner

AAOI

$9.04B

Max Drawdown

Winner

PTGX

85.79%

AAOI

98.49%

Sharpe Ratio

Winner

PTGX

1.98

AAOI

1.68

5Y Beta

Winner

PTGX

0.24

AAOI

3.81

Industry

PTGX

Biotechnology

AAOI

Communication Equipment

P/E Ratio

PTGX

-76.12

Winner

AAOI

-185.08

Forward P/E

Winner

PTGX

29.15

AAOI

84.03

PEG Ratio

Winner

PTGX

0.00

AAOI

0.78

5Y EPS CAGR

Winner

PTGX

1.43%

AAOI

-23.67%

Debt to Equity

Winner

PTGX

0.00%

AAOI

3.73%

Free Cash Flow Yield

Winner

PTGX

-1.31%

AAOI

-4.62%

P/S Ratio

PTGX

121.63

Winner

AAOI

18.11

P/B Ratio

PTGX

13.82

Winner

AAOI

8.78

PTGX vs AAOI - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	AAOI
1 month	+24.25%	-31.53%
3 months	+32.99%	-20.37%
6 months	+63.82%	+252.29%
1 year	+148.78%	+324.50%
5 years(CAGR)	+23.25%	+71.73%
10 years(CAGR)	+27.64%	+26.92%
Max(CAGR)	+27.64%	+21.48%

Winner

PTGX

+24.25%

AAOI

-31.53%

Winner

PTGX

+32.99%

AAOI

-20.37%

PTGX

+63.82%

Winner

AAOI

+252.29%

PTGX

+148.78%

Winner

AAOI

+324.50%

5Y(CAGR)

PTGX

+23.25%

Winner

AAOI

+71.73%

10Y(CAGR)

Winner

PTGX

+27.64%

AAOI

+26.92%

Max(CAGR)

Winner

PTGX

+27.64%

AAOI

+21.48%

PTGX vs AAOI - Annual Returns (2013 - 2026)

Returns include dividend reinvestment.

Year	PTGX	AAOI
2026	+50.75%	+202.83%
2025	+124.06%	-2.08%
2024	+64.82%	+97.22%
2023	+112.71%	+927.66%
2022	-69.11%	-64.14%
2021	+74.49%	-41.32%
2020	+190.91%	-31.92%
2019	+2.32%	-25.19%
2018	-68.18%	-59.30%
2017	-1.79%	+63.72%
2016	+87.95%	+43.89%
2015	N/A	+59.04%
2014	N/A	-23.31%
2013	N/A	+50.70%

PTGX vs AAOI Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for AAOI was -98.49%, occurring on Jul 11, 2022. Recovery took 2156 trading sessions.

The current PTGX drawdown is -6.70%. The current AAOI drawdown is -46.25%.

Rank	PTGX	AAOI
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-98.49% Aug 1, 2017 - Mar 2, 2026
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-69.44% Mar 10, 2014 - Jan 12, 2017
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-48.72% May 13, 2026 - Jul 7, 2026
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-33.40% Mar 11, 2026 - Apr 8, 2026
#5	-19.04% Mar 19, 2021 - May 18, 2021	-31.83% Mar 27, 2017 - May 9, 2017
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-21.75% Jun 2, 2017 - Jul 13, 2017
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-20.81% Dec 11, 2013 - Feb 20, 2014
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-18.84% May 1, 2026 - May 11, 2026
#9	-12.03% Apr 17, 2026 - Jun 11, 2026	-16.03% Apr 20, 2026 - Apr 30, 2026
#10	-11.53% Aug 19, 2016 - Aug 31, 2016	-13.09% Mar 7, 2017 - Mar 24, 2017
#11	-9.62% Jun 8, 2021 - Jun 11, 2021	-9.60% Oct 22, 2013 - Nov 29, 2013
#12	-8.53% Aug 27, 2025 - Sep 18, 2025	-7.11% Feb 21, 2014 - Feb 28, 2014
#13	-7.43% Mar 31, 2026 - Apr 15, 2026	-6.99% Mar 2, 2026 - Mar 9, 2026
#14	-7.20% Jun 14, 2021 - Jun 16, 2021	-6.95% Apr 13, 2026 - Apr 16, 2026
#15	-6.70% Jul 7, 2026 - Jul 10, 2026	-6.67% Nov 29, 2013 - Dec 6, 2013