PTGX vs NPO

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and EnPro Industries Inc (NPO, Company).

PTGX is from the Healthcare sector, while NPO is from the Industrials sector.

5-Year PerformanceNPO has outperformed PTGX, delivering a return of +28.2% compared to +24.4%

PTGX vs NPO - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	NPO(COMPANY)
Market Cap	$6.48B	$6.44B
Max Drawdown	85.79%	73.26%
Sharpe Ratio	1.74	1.53
5Y Beta	0.26	1.50
Industry	Biotechnology	Specialty Industrial Machinery
P/E Ratio	-54.82	64.36
Forward P/E	21.37	33.11
PEG Ratio	0.00	1.34
Dividend Yield	N/A	0.42%
5Y Dividends CAGR	N/A	8.24%
5Y EPS CAGR	1.43%	6.73%
Debt to Equity	0.00%	38.74%
Free Cash Flow Yield	-1.82%	-0.43%
P/S Ratio	87.39	5.50
P/B Ratio	9.90	4.04

Market Cap

Winner

PTGX

$6.48B

NPO

$6.44B

Max Drawdown

PTGX

85.79%

Winner

NPO

73.26%

Sharpe Ratio

Winner

PTGX

1.74

NPO

1.53

5Y Beta

Winner

PTGX

0.26

NPO

1.50

Industry

PTGX

Biotechnology

NPO

Specialty Industrial Machinery

P/E Ratio

Winner

PTGX

-54.82

NPO

64.36

Forward P/E

Winner

PTGX

21.37

NPO

33.11

PEG Ratio

Winner

PTGX

0.00

NPO

1.34

Dividend Yield

PTGX

N/A

NPO

0.42%

5Y Dividends CAGR

PTGX

N/A

NPO

8.24%

5Y EPS CAGR

PTGX

1.43%

Winner

NPO

6.73%

Debt to Equity

Winner

PTGX

0.00%

NPO

38.74%

Free Cash Flow Yield

PTGX

-1.82%

Winner

NPO

-0.43%

P/S Ratio

PTGX

87.39

Winner

NPO

5.50

P/B Ratio

PTGX

9.90

Winner

NPO

4.04

PTGX vs NPO - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	NPO
1 month	-3.66%	+7.40%
3 months	+23.26%	+10.44%
6 months	+19.45%	+40.79%
1 year	+122.63%	+68.85%
5 years(CAGR)	+24.38%	+28.16%
10 years(CAGR)	+24.80%	+21.64%
Max(CAGR)	+24.80%	+16.76%

PTGX

-3.66%

Winner

NPO

+7.40%

Winner

PTGX

+23.26%

NPO

+10.44%

PTGX

+19.45%

Winner

NPO

+40.79%

Winner

PTGX

+122.63%

NPO

+68.85%

5Y(CAGR)

PTGX

+24.38%

Winner

NPO

+28.16%

10Y(CAGR)

Winner

PTGX

+24.80%

NPO

+21.64%

Max(CAGR)

Winner

PTGX

+24.80%

NPO

+16.76%

PTGX vs NPO - Annual Returns (2002 - 2026)

Returns include dividend reinvestment.

Year	PTGX	NPO
2026	+17.01%	+38.33%
2025	+124.06%	+27.37%
2024	+64.82%	+11.54%
2023	+112.71%	+45.70%
2022	-69.11%	+0.14%
2021	+74.49%	+51.83%
2020	+190.91%	+13.62%
2019	+2.32%	+10.28%
2018	-68.18%	-34.84%
2017	-1.79%	+39.41%
2016	+87.95%	+59.13%
2015	N/A	-28.56%
2014	N/A	+10.22%
2013	N/A	+37.69%
2012	N/A	+20.86%
2011	N/A	-21.70%
2010	N/A	+51.79%
2009	N/A	+20.59%
2008	N/A	-29.56%
2007	N/A	-6.87%
2006	N/A	+22.68%
2005	N/A	-7.55%
2004	N/A	+101.98%
2003	N/A	+251.39%
2002	N/A	-52.66%

PTGX vs NPO Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for NPO was -73.26%, occurring on Oct 14, 2002. Recovery took 239 trading sessions.

The current PTGX drawdown is -3.75%. The current NPO drawdown is -6.32%.

Rank	PTGX	NPO
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-73.26% May 28, 2002 - May 8, 2003
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-69.88% Jul 12, 2007 - Jun 28, 2011
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-65.76% Dec 27, 2017 - Mar 8, 2021
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-49.65% Jan 21, 2014 - Jul 10, 2017
#5	-19.04% Mar 19, 2021 - May 18, 2021	-44.37% Jul 19, 2011 - Mar 22, 2013
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-36.50% Jul 8, 2003 - Dec 16, 2003
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-33.79% Jan 13, 2022 - Nov 3, 2022
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-33.72% Feb 19, 2025 - Jul 25, 2025
#9	-11.53% Aug 19, 2016 - Aug 31, 2016	-26.40% Aug 2, 2004 - Nov 3, 2004
#10	-9.62% Jun 8, 2021 - Jun 11, 2021	-25.60% Dec 29, 2004 - Jul 28, 2005
#11	-8.53% Aug 27, 2025 - Sep 18, 2025	-25.41% May 4, 2006 - Feb 20, 2007
#12	-7.43% Mar 31, 2026 - Apr 15, 2026	-24.78% Nov 15, 2022 - Jun 13, 2023
#13	-7.20% Jun 14, 2021 - Jun 16, 2021	-24.68% Aug 31, 2005 - Mar 30, 2006
#14	-7.18% Apr 17, 2026 - May 1, 2026	-22.36% Jul 18, 2023 - Dec 14, 2023
#15	-6.02% Nov 26, 2025 - Dec 8, 2025	-18.74% Jun 8, 2021 - Nov 5, 2021