PTGX vs LSTR

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and Landstar System Inc (LSTR, Company).

PTGX is from the Healthcare sector, while LSTR is from the Industrials sector.

5-Year PerformancePTGX has outperformed LSTR, delivering a return of +24.4% compared to +4.8%

PTGX vs LSTR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	LSTR(COMPANY)
Market Cap	$6.48B	$6.44B
Max Drawdown	85.79%	53.35%
Sharpe Ratio	1.74	1.00
5Y Beta	0.26	0.73
Industry	Biotechnology	Integrated Freight & Logistics
P/E Ratio	-54.82	50.27
Forward P/E	21.37	32.89
PEG Ratio	0.00	1.29
Dividend Yield	N/A	0.88%
5Y Dividends CAGR	N/A	7.09%
5Y EPS CAGR	1.43%	-9.61%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-1.82%	3.63%
P/S Ratio	87.39	1.34
P/B Ratio	9.90	7.73

Market Cap

Winner

PTGX

$6.48B

LSTR

$6.44B

Max Drawdown

PTGX

85.79%

Winner

LSTR

53.35%

Sharpe Ratio

Winner

PTGX

1.74

LSTR

1.00

5Y Beta

Winner

PTGX

0.26

LSTR

0.73

Industry

PTGX

Biotechnology

LSTR

Integrated Freight & Logistics

P/E Ratio

Winner

PTGX

-54.82

LSTR

50.27

Forward P/E

Winner

PTGX

21.37

LSTR

32.89

PEG Ratio

Winner

PTGX

0.00

LSTR

1.29

Dividend Yield

PTGX

N/A

LSTR

0.88%

5Y Dividends CAGR

PTGX

N/A

LSTR

7.09%

5Y EPS CAGR

Winner

PTGX

1.43%

LSTR

-9.61%

Debt to Equity

PTGX

0.00%

LSTR

0.00%

Free Cash Flow Yield

PTGX

-1.82%

Winner

LSTR

3.63%

P/S Ratio

PTGX

87.39

Winner

LSTR

1.34

P/B Ratio

PTGX

9.90

Winner

LSTR

7.73

PTGX vs LSTR - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	LSTR
1 month	-3.66%	+7.16%
3 months	+23.26%	+25.07%
6 months	+19.45%	+53.72%
1 year	+122.63%	+41.36%
5 years(CAGR)	+24.38%	+4.78%
10 years(CAGR)	+24.80%	+13.12%
Max(CAGR)	+24.80%	+15.66%

PTGX

-3.66%

Winner

LSTR

+7.16%

PTGX

+23.26%

Winner

LSTR

+25.07%

PTGX

+19.45%

Winner

LSTR

+53.72%

Winner

PTGX

+122.63%

LSTR

+41.36%

5Y(CAGR)

Winner

PTGX

+24.38%

LSTR

+4.78%

10Y(CAGR)

Winner

PTGX

+24.80%

LSTR

+13.12%

Max(CAGR)

Winner

PTGX

+24.80%

LSTR

+15.66%

PTGX vs LSTR - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	PTGX	LSTR
2026	+17.01%	+32.60%
2025	+124.06%	-13.66%
2024	+64.82%	-8.59%
2023	+112.71%	+20.61%
2022	-69.11%	-6.83%
2021	+74.49%	+37.14%
2020	+190.91%	+21.63%
2019	+2.32%	+18.51%
2018	-68.18%	-6.64%
2017	-1.79%	+22.00%
2016	+87.95%	+46.33%
2015	N/A	-17.08%
2014	N/A	+27.98%
2013	N/A	+8.10%
2012	N/A	+12.22%
2011	N/A	+16.61%
2010	N/A	+4.84%
2009	N/A	-2.45%
2008	N/A	-6.97%
2007	N/A	+5.49%
2006	N/A	-8.43%
2005	N/A	+11.50%
2004	N/A	+95.28%
2003	N/A	+30.07%
2002	N/A	+62.00%
2001	N/A	+29.48%
2000	N/A	+38.81%
1999	N/A	+4.42%

PTGX vs LSTR Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for LSTR was -53.20%, occurring on Mar 9, 2009. Recovery took 942 trading sessions.

The current PTGX drawdown is -3.75%. The current LSTR drawdown is -0.91%.

Rank	PTGX	LSTR
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-53.20% Jun 19, 2008 - Mar 15, 2012
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-44.34% Apr 12, 2000 - Feb 12, 2001
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-38.75% Jul 26, 2023 - Sep 23, 2025
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-31.03% Nov 28, 2014 - Nov 10, 2016
#5	-19.04% Mar 19, 2021 - May 18, 2021	-30.13% Sep 11, 2018 - Jul 29, 2020
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-28.21% May 23, 2007 - Mar 20, 2008
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-28.02% Mar 7, 2005 - Sep 16, 2005
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-24.33% Nov 4, 2021 - Feb 2, 2023
#9	-11.53% Aug 19, 2016 - Aug 31, 2016	-23.45% Jul 17, 2001 - Jan 23, 2002
#10	-9.62% Jun 8, 2021 - Jun 11, 2021	-22.52% Jul 3, 2006 - Apr 19, 2007
#11	-8.53% Aug 27, 2025 - Sep 18, 2025	-20.01% Apr 3, 2012 - Jan 22, 2013
#12	-7.43% Mar 31, 2026 - Apr 15, 2026	-18.42% Jun 17, 2002 - Aug 16, 2002
#13	-7.20% Jun 14, 2021 - Jun 16, 2021	-18.23% Feb 9, 2000 - Apr 12, 2000
#14	-7.18% Apr 17, 2026 - May 1, 2026	-18.18% Oct 15, 2002 - Dec 19, 2002
#15	-6.02% Nov 26, 2025 - Dec 8, 2025	-17.91% Dec 8, 1999 - Jan 10, 2000