PTGX vs MSA

Comparison between Protagonist Therapeutics Inc (PTGX, Company) and MSA Safety Inc (MSA, Company).

PTGX is from the Healthcare sector, while MSA is from the Industrials sector.

5-Year PerformancePTGX has outperformed MSA, delivering a return of +27.4% compared to +1.5%

PTGX vs MSA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PTGX(COMPANY)	MSA(COMPANY)
Market Cap	$6.67B	$6.68B
Max Drawdown	85.79%	71.48%
Sharpe Ratio	1.87	0.36
5Y Beta	0.26	0.80
Industry	Biotechnology	Security & Protection Services
P/E Ratio	-56.45	23.13
Forward P/E	23.75	19.61
PEG Ratio	0.00	10.04
Dividend Yield	N/A	1.22%
5Y Dividends CAGR	N/A	4.25%
5Y EPS CAGR	1.43%	20.02%
Debt to Equity	0.00%	45.24%
Free Cash Flow Yield	-1.77%	4.63%
P/S Ratio	90.08	3.47
P/B Ratio	9.75	4.85

Market Cap

PTGX

$6.67B

Winner

MSA

$6.68B

Max Drawdown

PTGX

85.79%

Winner

MSA

71.48%

Sharpe Ratio

Winner

PTGX

1.87

MSA

0.36

5Y Beta

Winner

PTGX

0.26

MSA

0.80

Industry

PTGX

Biotechnology

MSA

Security & Protection Services

P/E Ratio

Winner

PTGX

-56.45

MSA

23.13

Forward P/E

PTGX

23.75

Winner

MSA

19.61

PEG Ratio

Winner

PTGX

0.00

MSA

10.04

Dividend Yield

PTGX

N/A

MSA

1.22%

5Y Dividends CAGR

PTGX

N/A

MSA

4.25%

5Y EPS CAGR

PTGX

1.43%

Winner

MSA

20.02%

Debt to Equity

Winner

PTGX

0.00%

MSA

45.24%

Free Cash Flow Yield

PTGX

-1.77%

Winner

MSA

4.63%

P/S Ratio

PTGX

90.08

Winner

MSA

3.47

P/B Ratio

PTGX

9.75

Winner

MSA

4.85

PTGX vs MSA - Historical Returns

Returns include dividend reinvestment.

Period	PTGX	MSA
1 month	-3.09%	+3.55%
3 months	+25.39%	-14.94%
6 months	+20.77%	+10.20%
1 year	+130.08%	+9.32%
5 years(CAGR)	+27.37%	+1.54%
10 years(CAGR)	+24.87%	+15.25%
Max(CAGR)	+24.87%	+15.54%

PTGX

-3.09%

Winner

MSA

+3.55%

Winner

PTGX

+25.39%

MSA

-14.94%

Winner

PTGX

+20.77%

MSA

+10.20%

Winner

PTGX

+130.08%

MSA

+9.32%

5Y(CAGR)

Winner

PTGX

+27.37%

MSA

+1.54%

10Y(CAGR)

Winner

PTGX

+24.87%

MSA

+15.25%

Max(CAGR)

Winner

PTGX

+24.87%

MSA

+15.54%

PTGX vs MSA - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	PTGX	MSA
2026	+17.21%	+6.16%
2025	+124.06%	-1.68%
2024	+64.82%	-0.19%
2023	+112.71%	+19.28%
2022	-69.11%	-1.31%
2021	+74.49%	+4.45%
2020	+190.91%	+17.61%
2019	+2.32%	+34.89%
2018	-68.18%	+21.47%
2017	-1.79%	+13.96%
2016	+87.95%	+66.79%
2015	N/A	-15.40%
2014	N/A	+7.28%
2013	N/A	+20.56%
2012	N/A	+31.32%
2011	N/A	+7.35%
2010	N/A	+19.69%
2009	N/A	+14.11%
2008	N/A	-51.53%
2007	N/A	+41.36%
2006	N/A	+0.89%
2005	N/A	-26.70%
2004	N/A	+90.76%
2003	N/A	+160.78%
2002	N/A	-18.11%
2001	N/A	+67.71%
2000	N/A	+20.00%
1999	N/A	+5.15%

PTGX vs MSA Drawdown Comparison

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The maximum drawdown for MSA was -70.36%, occurring on Mar 9, 2009. Recovery took 1296 trading sessions.

The current PTGX drawdown is -3.59%. The current MSA drawdown is -15.19%.

Rank	PTGX	MSA
#1	-85.79% Sep 1, 2021 - Mar 10, 2025	-70.36% Dec 20, 2007 - Feb 14, 2013
#2	-82.13% Dec 5, 2016 - Feb 16, 2021	-45.18% Oct 4, 2001 - Aug 20, 2003
#3	-31.58% Mar 11, 2025 - Aug 27, 2025	-38.39% Feb 13, 2020 - Oct 8, 2020
#4	-20.33% Oct 17, 2016 - Nov 10, 2016	-35.28% Feb 22, 2021 - Jun 27, 2023
#5	-19.04% Mar 19, 2021 - May 18, 2021	-34.76% Jul 3, 2014 - Aug 23, 2016
#6	-16.38% Dec 12, 2025 - Mar 9, 2026	-34.27% Jul 16, 2024 - Feb 11, 2026
#7	-15.52% Oct 10, 2025 - Nov 24, 2025	-33.06% Dec 17, 2004 - Aug 8, 2007
#8	-12.77% Feb 16, 2021 - Mar 2, 2021	-26.47% Jun 13, 2000 - Dec 19, 2000
#9	-11.53% Aug 19, 2016 - Aug 31, 2016	-26.07% Jan 20, 2004 - Apr 5, 2004
#10	-9.62% Jun 8, 2021 - Jun 11, 2021	-21.83% Apr 5, 2004 - Jun 7, 2004
#11	-8.53% Aug 27, 2025 - Sep 18, 2025	-20.67% Feb 12, 2026 - Mar 30, 2026
#12	-7.43% Mar 31, 2026 - Apr 15, 2026	-20.64% Jun 1, 2017 - Nov 28, 2017
#13	-7.20% Jun 14, 2021 - Jun 16, 2021	-20.02% Sep 1, 2023 - Feb 29, 2024
#14	-7.18% Apr 17, 2026 - May 1, 2026	-19.78% Nov 16, 2018 - May 2, 2019
#15	-6.02% Nov 26, 2025 - Dec 8, 2025	-19.65% Aug 8, 2007 - Dec 20, 2007