PEN vs IONS

Comparison between Penumbra Inc (PEN, Company) and Ionis Pharmaceuticals Inc (IONS, Company).

Both PEN and IONS are from the Healthcare sector.

5-Year PerformanceIONS has outperformed PEN, delivering a return of +15.7% compared to +3.5%

PEN vs IONS - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PEN(COMPANY)	IONS(COMPANY)
Market Cap	$13B	$13B
Max Drawdown	62.64%	91.72%
Sharpe Ratio	0.37	1.90
5Y Beta	0.54	0.75
Industry	Medical Devices	Biotechnology
P/E Ratio	77.46	-72.93
Forward P/E	62.89	96.15
PEG Ratio	0.73	-1.54
5Y EPS CAGR	46.16%	-21.44%
Debt to Equity	0.00%	88.01%
Free Cash Flow Yield	1.67%	-7.62%
P/S Ratio	9.08	12.00
P/B Ratio	8.94	25.84

Market Cap

PEN

$13B

Winner

IONS

$13B

Max Drawdown

Winner

PEN

62.64%

IONS

91.72%

Sharpe Ratio

PEN

0.37

Winner

IONS

1.90

5Y Beta

Winner

PEN

0.54

IONS

0.75

Industry

PEN

Medical Devices

IONS

Biotechnology

P/E Ratio

PEN

77.46

Winner

IONS

-72.93

Forward P/E

Winner

PEN

62.89

IONS

96.15

PEG Ratio

PEN

0.73

Winner

IONS

-1.54

5Y EPS CAGR

Winner

PEN

46.16%

IONS

-21.44%

Debt to Equity

Winner

PEN

0.00%

IONS

88.01%

Free Cash Flow Yield

Winner

PEN

1.67%

IONS

-7.62%

P/S Ratio

Winner

PEN

9.08

IONS

12.00

P/B Ratio

Winner

PEN

8.94

IONS

25.84

PEN vs IONS - Historical Returns

Returns include dividend reinvestment.

Period	PEN	IONS
1 month	-2.67%	+0.97%
3 months	-4.96%	-10.71%
6 months	+21.05%	+2.94%
1 year	+11.60%	+131.18%
5 years(CAGR)	+3.49%	+15.68%
10 years(CAGR)	+19.66%	+8.22%
Max(CAGR)	+21.31%	+7.64%

PEN

-2.67%

Winner

IONS

+0.97%

Winner

PEN

-4.96%

IONS

-10.71%

Winner

PEN

+21.05%

IONS

+2.94%

PEN

+11.60%

Winner

IONS

+131.18%

5Y(CAGR)

PEN

+3.49%

Winner

IONS

+15.68%

10Y(CAGR)

Winner

PEN

+19.66%

IONS

+8.22%

Max(CAGR)

Winner

PEN

+21.31%

IONS

+7.64%

PEN vs IONS - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	PEN	IONS
2026	+4.14%	-4.97%
2025	+29.55%	+128.05%
2024	-2.98%	-33.88%
2023	+13.72%	+34.62%
2022	-21.66%	+15.86%
2021	+63.62%	-46.41%
2020	+6.84%	-7.14%
2019	+33.48%	+12.35%
2018	+35.25%	+9.77%
2017	+46.92%	+6.25%
2016	+14.52%	-22.45%
2015	+30.29%	+0.58%
2014	N/A	+54.85%
2013	N/A	+268.21%
2012	N/A	+44.00%
2011	N/A	-29.93%
2010	N/A	-10.20%
2009	N/A	-23.22%
2008	N/A	-7.80%
2007	N/A	+44.10%
2006	N/A	+111.81%
2005	N/A	-9.66%
2004	N/A	-13.36%
2003	N/A	-4.97%
2002	N/A	-68.69%
2001	N/A	+130.55%
2000	N/A	+77.49%
1999	N/A	-44.34%

PEN vs IONS Drawdown Comparison

The maximum drawdown for PEN was -62.64%, occurring on Jun 16, 2022. Recovery took 511 trading sessions.

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The current PEN drawdown is -10.34%. The current IONS drawdown is -12.47%.

Rank	PEN	IONS
#1	-62.64% Apr 28, 2021 - May 9, 2023	-91.43% Mar 6, 2000 - Jul 11, 2013
#2	-52.44% Jun 30, 2023 - Jan 15, 2026	-73.25% Mar 19, 2015 - Mar 14, 2019
#3	-35.86% Nov 12, 2020 - Feb 9, 2021	-70.39% Apr 8, 2019 - Feb 6, 2026
#4	-35.83% Feb 19, 2020 - Jul 8, 2020	-68.14% Dec 2, 1999 - Mar 1, 2000
#5	-31.65% Jun 6, 2018 - Jun 14, 2019	-61.05% Feb 21, 2014 - Dec 10, 2014
#6	-28.12% Jul 24, 2019 - Feb 11, 2020	-28.35% Jul 12, 2013 - Sep 19, 2013
#7	-26.97% Nov 9, 2017 - Mar 6, 2018	-20.89% Sep 23, 2013 - Nov 27, 2013
#8	-26.12% Sep 22, 2016 - Feb 21, 2017	-19.78% Jan 12, 2015 - Mar 19, 2015
#9	-24.61% Jan 4, 2016 - Jun 6, 2016	-19.45% Feb 6, 2026 - Mar 24, 2026
#10	-21.70% Aug 13, 2020 - Oct 27, 2020	-11.84% Dec 12, 2014 - Dec 19, 2014
#11	-13.42% Dec 1, 2015 - Dec 11, 2015	-11.49% Dec 19, 2014 - Jan 5, 2015
#12	-12.79% Mar 1, 2021 - Apr 23, 2021	-8.95% Jan 31, 2014 - Feb 13, 2014
#13	-12.45% Oct 8, 2015 - Nov 13, 2015	-8.58% Nov 11, 1999 - Nov 17, 1999
#14	-11.94% Jun 23, 2017 - Oct 2, 2017	-7.67% Jan 22, 2014 - Jan 31, 2014
#15	-11.02% Mar 21, 2018 - Apr 27, 2018	-7.49% Dec 23, 2013 - Jan 8, 2014