PB vs PTGX

Comparison between Prosperity Bancshares Inc (PB, Company) and Protagonist Therapeutics Inc (PTGX, Company).

PB is from the Financial Services sector, while PTGX is from the Healthcare sector.

5-Year PerformancePTGX has outperformed PB, delivering a return of +27.4% compared to +0.8%

PB vs PTGX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	PB(COMPANY)	PTGX(COMPANY)
Market Cap	$6.68B	$6.67B
Max Drawdown	49.66%	85.79%
Sharpe Ratio	-0.25	1.87
5Y Beta	0.71	0.26
Industry	Banks - Regional	Biotechnology
P/E Ratio	12.00	-56.45
Forward P/E	11.26	23.75
PEG Ratio	2.22	0.00
Dividend Yield	3.52%	N/A
5Y Dividends CAGR	4.49%	N/A
5Y EPS CAGR	-0.74%	1.43%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	7.84%	-1.77%
P/S Ratio	5.10	90.08
P/B Ratio	0.85	9.75

Market Cap

Winner

$6.68B

PTGX

$6.67B

Max Drawdown

Winner

49.66%

PTGX

85.79%

Sharpe Ratio

-0.25

Winner

PTGX

1.87

5Y Beta

0.71

Winner

PTGX

0.26

Industry

Banks - Regional

PTGX

Biotechnology

P/E Ratio

12.00

Winner

PTGX

-56.45

Forward P/E

Winner

11.26

PTGX

23.75

PEG Ratio

2.22

Winner

PTGX

0.00

Dividend Yield

3.52%

PTGX

N/A

5Y Dividends CAGR

4.49%

PTGX

N/A

5Y EPS CAGR

-0.74%

Winner

PTGX

1.43%

Debt to Equity

0.00%

PTGX

0.00%

Free Cash Flow Yield

Winner

7.84%

PTGX

-1.77%

P/S Ratio

Winner

5.10

PTGX

90.08

P/B Ratio

Winner

0.85

PTGX

9.75

PB vs PTGX - Historical Returns

Returns include dividend reinvestment.

Period	PB	PTGX
1 month	-3.79%	-3.09%
3 months	-7.59%	+25.39%
6 months	+1.30%	+20.77%
1 year	-4.62%	+130.08%
5 years(CAGR)	+0.79%	+27.37%
10 years(CAGR)	+5.97%	+24.87%
Max(CAGR)	+10.63%	+24.87%

-3.79%

Winner

PTGX

-3.09%

-7.59%

Winner

PTGX

+25.39%

+1.30%

Winner

PTGX

+20.77%

-4.62%

Winner

PTGX

+130.08%

5Y(CAGR)

+0.79%

Winner

PTGX

+27.37%

10Y(CAGR)

+5.97%

Winner

PTGX

+24.87%

Max(CAGR)

+10.63%

Winner

PTGX

+24.87%

PB vs PTGX - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	PB	PTGX
2026	-3.60%	+17.21%
2025	-4.28%	+124.06%
2024	+14.05%	+64.82%
2023	-2.68%	+112.71%
2022	+3.09%	-69.11%
2021	+7.95%	+74.49%
2020	-1.17%	+190.91%
2019	+14.64%	+2.32%
2018	-9.11%	-68.18%
2017	-0.56%	-1.79%
2016	+57.83%	+87.95%
2015	-10.79%	N/A
2014	-9.28%	N/A
2013	+47.82%	N/A
2012	+4.78%	N/A
2011	+2.66%	N/A
2010	-0.08%	N/A
2009	+43.04%	N/A
2008	+6.10%	N/A
2007	-15.00%	N/A
2006	+19.81%	N/A
2005	+0.63%	N/A
2004	+31.73%	N/A
2003	+20.00%	N/A
2002	+42.51%	N/A
2001	+38.92%	N/A
2000	+21.01%	N/A
1999	-0.06%	N/A

PB vs PTGX Drawdown Comparison

The maximum drawdown for PB was -47.91%, occurring on Jan 25, 2016. Recovery took 661 trading sessions.

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The current PB drawdown is -17.80%. The current PTGX drawdown is -3.59%.

Rank	PB	PTGX
#1	-47.91% Apr 2, 2014 - Nov 14, 2016	-85.79% Sep 1, 2021 - Mar 10, 2025
#2	-47.61% Sep 19, 2008 - Nov 20, 2009	-82.13% Dec 5, 2016 - Feb 16, 2021
#3	-42.29% Mar 12, 2018 - Feb 19, 2021	-31.58% Mar 11, 2025 - Aug 27, 2025
#4	-37.19% Mar 21, 2007 - Sep 19, 2008	-20.33% Oct 17, 2016 - Nov 10, 2016
#5	-34.39% Feb 7, 2023 - Sep 19, 2024	-19.04% Mar 19, 2021 - May 18, 2021
#6	-34.27% Apr 15, 2010 - Mar 31, 2011	-16.38% Dec 12, 2025 - Mar 9, 2026
#7	-31.50% Jul 21, 2011 - Mar 13, 2012	-15.52% Oct 10, 2025 - Nov 24, 2025
#8	-26.41% Mar 1, 2017 - Jan 24, 2018	-12.77% Feb 16, 2021 - Mar 2, 2021
#9	-25.92% Nov 19, 1999 - Sep 28, 2000	-11.53% Aug 19, 2016 - Aug 31, 2016
#10	-24.83% Nov 25, 2024 - Oct 16, 2025	-9.62% Jun 8, 2021 - Jun 11, 2021
#11	-22.56% Aug 14, 2002 - Jul 1, 2003	-8.53% Aug 27, 2025 - Sep 18, 2025
#12	-22.10% Aug 13, 2001 - Jan 10, 2002	-7.43% Mar 31, 2026 - Apr 15, 2026
#13	-17.58% Jan 14, 2022 - Feb 2, 2023	-7.20% Jun 14, 2021 - Jun 16, 2021
#14	-17.44% Mar 12, 2021 - Jan 13, 2022	-7.18% Apr 17, 2026 - May 1, 2026
#15	-16.77% Mar 19, 2012 - Mar 7, 2013	-6.02% Nov 26, 2025 - Dec 8, 2025