JHG vs SYRE

Comparison between Janus Henderson Group plc Ordinary Shares (JHG, Company) and Spyre Therapeutics Inc (SYRE, Company).

JHG is from the Financial Services sector, while SYRE is from the Healthcare sector.

5-Year PerformanceJHG has outperformed SYRE, delivering a return of +10.6% compared to -10.2%

JHG vs SYRE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	JHG(COMPANY)	SYRE(COMPANY)
Market Cap	$8B	$8.05B
Max Drawdown	92.68%	99.11%
Sharpe Ratio	1.39	2.92
5Y Beta	N/A	1.76
Industry	Asset Management	Biotechnology
P/E Ratio	10.22	-41.36
Forward P/E	12.00	N/A
PEG Ratio	0.10	N/A
Dividend Yield	1.54%	N/A
5Y Dividends CAGR	2.00%	N/A
5Y EPS CAGR	9.39%	-2.15%
Debt to Equity	7.64%	0.00%
Free Cash Flow Yield	11.76%	-2.31%

Market Cap

JHG

$8B

Winner

SYRE

$8.05B

Max Drawdown

Winner

JHG

92.68%

SYRE

99.11%

Sharpe Ratio

JHG

1.39

Winner

SYRE

2.92

5Y Beta

JHG

N/A

SYRE

1.76

Industry

JHG

Asset Management

SYRE

Biotechnology

P/E Ratio

JHG

10.22

Winner

SYRE

-41.36

Forward P/E

JHG

12.00

SYRE

N/A

PEG Ratio

JHG

0.10

SYRE

N/A

Dividend Yield

JHG

1.54%

SYRE

N/A

5Y Dividends CAGR

JHG

2.00%

SYRE

N/A

5Y EPS CAGR

Winner

JHG

9.39%

SYRE

-2.15%

Debt to Equity

JHG

7.64%

Winner

SYRE

0.00%

Free Cash Flow Yield

Winner

JHG

11.76%

SYRE

-2.31%

JHG vs SYRE - Historical Returns

Returns include dividend reinvestment.

Period	JHG	SYRE
1 month	+0.43%	+22.12%
3 months	+1.03%	+47.95%
6 months	+9.21%	+208.46%
1 year	+34.10%	+566.69%
5 years(CAGR)	+10.64%	-10.25%
10 years(CAGR)	+10.48%	-1.01%
Max(CAGR)	-0.05%	-8.15%

JHG

+0.43%

Winner

SYRE

+22.12%

JHG

+1.03%

Winner

SYRE

+47.95%

JHG

+9.21%

Winner

SYRE

+208.46%

JHG

+34.10%

Winner

SYRE

+566.69%

5Y(CAGR)

Winner

JHG

+10.64%

SYRE

-10.25%

10Y(CAGR)

Winner

JHG

+10.48%

SYRE

-1.01%

Max(CAGR)

Winner

JHG

-0.05%

SYRE

-8.15%

JHG vs SYRE - Annual Returns (2000 - 2026)

Returns include dividend reinvestment.

Year	JHG	SYRE
2026	+8.73%	+233.78%
2025	+14.66%	+37.36%
2024	+48.50%	+8.79%
2023	+33.06%	+104.27%
2022	-40.58%	-90.57%
2021	+38.94%	-44.51%
2020	+41.59%	+1.55%
2019	+26.37%	-4.98%
2018	-43.67%	+39.22%
2017	+36.64%	+18.38%
2016	-3.63%	-55.48%
2015	-12.32%	N/A
2014	+33.42%	N/A
2013	+38.21%	N/A
2012	+28.70%	N/A
2011	-52.91%	N/A
2010	-6.22%	N/A
2009	+50.28%	N/A
2008	-74.57%	N/A
2007	+51.59%	N/A
2006	+14.23%	N/A
2005	+13.60%	N/A
2004	+0.66%	N/A
2003	+23.20%	N/A
2002	-51.63%	N/A
2001	-22.91%	N/A
2000	+2.76%	N/A

JHG vs SYRE Drawdown Comparison

The maximum drawdown for JHG was -92.68%, occurring on Mar 2, 2009. This drawdown has not yet recovered.

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The current JHG drawdown is -29.76%. The current SYRE drawdown is -65.95%.

Rank	JHG	SYRE
#1	-92.68% Sep 11, 2000 - Mar 2, 2009	-99.11% Apr 8, 2016 - Jun 21, 2023
#2	-18.24% Jul 24, 2000 - Sep 7, 2000	N/A
#3	-8.92% Jul 14, 2000 - Jul 21, 2000	N/A

Correlation

Correlation between JHG and SYRE is -0.49 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.49

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