ITUB vs VRTX

Comparison between Itau Unibanco Holding S.A. (ITUB, Company) and Vertex Pharmaceuticals Inc (VRTX, Company).

ITUB is from the Financial Services sector, while VRTX is from the Healthcare sector.

5-Year PerformanceITUB has outperformed VRTX, delivering a return of +29.6% compared to +14.9%

ITUB vs VRTX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ITUB(COMPANY)	VRTX(COMPANY)
Market Cap	$110B	$109B
Max Drawdown	74.70%	91.77%
Sharpe Ratio	1.46	0.04
5Y Beta	0.68	0.51
Industry	Banks - Regional	Biotechnology
P/E Ratio	11.48	25.09
Forward P/E	9.30	22.57
PEG Ratio	4.81	2.11
Dividend Yield	41.10%	N/A
5Y Dividends CAGR	50.88%	N/A
5Y EPS CAGR	15.16%	9.89%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	23.04%	3.41%
P/S Ratio	0.67	8.88
P/B Ratio	2.29	5.65

Market Cap

Winner

ITUB

$110B

VRTX

$109B

Max Drawdown

Winner

ITUB

74.70%

VRTX

91.77%

Sharpe Ratio

Winner

ITUB

1.46

VRTX

0.04

5Y Beta

ITUB

0.68

Winner

VRTX

0.51

Industry

ITUB

Banks - Regional

VRTX

Biotechnology

P/E Ratio

Winner

ITUB

11.48

VRTX

25.09

Forward P/E

Winner

ITUB

9.30

VRTX

22.57

PEG Ratio

ITUB

4.81

Winner

VRTX

2.11

Dividend Yield

ITUB

41.10%

VRTX

N/A

5Y Dividends CAGR

ITUB

50.88%

VRTX

N/A

5Y EPS CAGR

Winner

ITUB

15.16%

VRTX

9.89%

Debt to Equity

ITUB

0.00%

VRTX

0.00%

Free Cash Flow Yield

Winner

ITUB

23.04%

VRTX

3.41%

P/S Ratio

Winner

ITUB

0.67

VRTX

8.88

P/B Ratio

Winner

ITUB

2.29

VRTX

5.65

ITUB vs VRTX - Historical Returns

Returns include dividend reinvestment.

Period	ITUB	VRTX
1 month	-5.01%	-3.18%
3 months	-9.25%	-8.72%
6 months	+21.87%	+4.97%
1 year	+51.55%	+0.05%
5 years(CAGR)	+29.56%	+14.85%
10 years(CAGR)	+18.14%	+17.19%
Max(CAGR)	+15.15%	+14.03%

ITUB

-5.01%

Winner

VRTX

-3.18%

ITUB

-9.25%

Winner

VRTX

-8.72%

Winner

ITUB

+21.87%

VRTX

+4.97%

Winner

ITUB

+51.55%

VRTX

+0.05%

5Y(CAGR)

Winner

ITUB

+29.56%

VRTX

+14.85%

10Y(CAGR)

Winner

ITUB

+18.14%

VRTX

+17.19%

Max(CAGR)

Winner

ITUB

+15.15%

VRTX

+14.03%

ITUB vs VRTX - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	ITUB	VRTX
2026	+17.08%	-4.93%
2025	+86.05%	+11.73%
2024	-21.94%	-2.00%
2023	+67.63%	+42.26%
2022	+29.71%	+29.77%
2021	-2.56%	-4.28%
2020	-32.18%	+7.70%
2019	+1.95%	+33.44%
2018	+8.21%	+8.37%
2017	+25.69%	+100.11%
2016	+111.60%	-40.05%
2015	-41.39%	+2.24%
2014	+11.81%	+60.91%
2013	-0.15%	+70.22%
2012	-10.71%	+30.00%
2011	-22.22%	-7.72%
2010	+3.44%	-20.82%
2009	+84.25%	+39.62%
2008	-39.27%	+31.23%
2007	+44.83%	-37.05%
2006	+47.32%	+34.12%
2005	+62.42%	+170.21%
2004	+58.50%	+0.67%
2003	+107.90%	-36.74%
2002	-40.98%	-35.41%
2001	N/A	-61.05%
2000	N/A	+281.33%
1999	N/A	+32.38%

ITUB vs VRTX Drawdown Comparison

The maximum drawdown for ITUB was -69.35%, occurring on Oct 24, 2008. Recovery took 381 trading sessions.

The maximum drawdown for VRTX was -91.77%, occurring on Nov 11, 2003. Recovery took 3434 trading sessions.

The current ITUB drawdown is -11.62%. The current VRTX drawdown is -16.82%.

Rank	ITUB	VRTX
#1	-69.35% May 30, 2008 - Dec 2, 2009	-91.77% Nov 2, 2000 - Jul 2, 2014
#2	-66.01% Sep 2, 2014 - Feb 8, 2017	-55.25% Mar 6, 2000 - Jun 16, 2000
#3	-65.93% Apr 10, 2002 - Oct 28, 2003	-49.10% Aug 19, 2015 - Jul 19, 2017
#4	-61.98% Feb 4, 2019 - Jun 15, 2023	-41.60% Jul 20, 2020 - Aug 15, 2022
#5	-47.93% Nov 4, 2010 - Aug 27, 2014	-29.08% Sep 28, 2000 - Oct 25, 2000
#6	-39.32% Feb 26, 2018 - Feb 4, 2019	-29.07% Nov 8, 2024 - Aug 8, 2025
#7	-37.02% May 9, 2006 - Dec 27, 2006	-22.82% Jul 12, 2000 - Aug 16, 2000
#8	-34.31% Jan 13, 2004 - Sep 16, 2004	-21.18% Sep 28, 2018 - Jan 18, 2019
#9	-28.93% Jul 23, 2007 - Oct 1, 2007	-19.52% Jan 21, 2000 - Feb 7, 2000
#10	-28.22% Dec 7, 2007 - Apr 30, 2008	-19.39% Feb 11, 2020 - Apr 6, 2020
#11	-28.20% Feb 27, 2024 - Apr 23, 2025	-17.73% Mar 12, 2018 - Jul 12, 2018
#12	-27.12% Jan 5, 2010 - Sep 29, 2010	-17.36% Jul 24, 2017 - Jan 23, 2018
#13	-23.21% Feb 15, 2017 - Sep 6, 2017	-15.45% Jan 18, 2019 - Oct 29, 2019
#14	-21.00% Oct 31, 2007 - Dec 7, 2007	-15.26% Jan 22, 2015 - Mar 16, 2015
#15	-18.02% Feb 11, 2026 - Mar 20, 2026	-14.46% Jul 11, 2014 - Sep 19, 2014