VRTX vs MFG

Comparison between Vertex Pharmaceuticals Inc (VRTX, Company) and Mizuho Financial Group Inc (MFG, Company).

VRTX is from the Healthcare sector, while MFG is from the Financial Services sector.

5-Year PerformanceMFG has outperformed VRTX, delivering a return of +28.2% compared to +14.9%

VRTX vs MFG - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	VRTX(COMPANY)	MFG(COMPANY)
Market Cap	$109B	$110B
Max Drawdown	91.77%	86.75%
Sharpe Ratio	0.04	1.97
5Y Beta	0.51	1.11
Industry	Biotechnology	Banks - Regional
P/E Ratio	25.09	15.72
Forward P/E	22.57	13.11
PEG Ratio	2.11	0.69
Dividend Yield	N/A	2.26%
5Y Dividends CAGR	N/A	32.63%
5Y EPS CAGR	9.89%	13.59%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	3.41%	-2.97%
P/S Ratio	8.88	0.03
P/B Ratio	5.65	1.44

Market Cap

VRTX

$109B

Winner

MFG

$110B

Max Drawdown

VRTX

91.77%

Winner

MFG

86.75%

Sharpe Ratio

VRTX

0.04

Winner

MFG

1.97

5Y Beta

Winner

VRTX

0.51

MFG

1.11

Industry

VRTX

Biotechnology

MFG

Banks - Regional

P/E Ratio

VRTX

25.09

Winner

MFG

15.72

Forward P/E

VRTX

22.57

Winner

MFG

13.11

PEG Ratio

VRTX

2.11

Winner

MFG

0.69

Dividend Yield

VRTX

N/A

MFG

2.26%

5Y Dividends CAGR

VRTX

N/A

MFG

32.63%

5Y EPS CAGR

VRTX

9.89%

Winner

MFG

13.59%

Debt to Equity

VRTX

0.00%

MFG

0.00%

Free Cash Flow Yield

Winner

VRTX

3.41%

MFG

-2.97%

P/S Ratio

VRTX

8.88

Winner

MFG

0.03

P/B Ratio

VRTX

5.65

Winner

MFG

1.44

VRTX vs MFG - Historical Returns

Returns include dividend reinvestment.

Period	VRTX	MFG
1 month	-3.18%	-1.25%
3 months	-8.72%	-11.33%
6 months	+4.97%	+31.07%
1 year	+0.05%	+77.28%
5 years(CAGR)	+14.85%	+28.18%
10 years(CAGR)	+17.19%	+14.27%
Max(CAGR)	+14.03%	+0.30%

VRTX

-3.18%

Winner

MFG

-1.25%

Winner

VRTX

-8.72%

MFG

-11.33%

VRTX

+4.97%

Winner

MFG

+31.07%

VRTX

+0.05%

Winner

MFG

+77.28%

5Y(CAGR)

VRTX

+14.85%

Winner

MFG

+28.18%

10Y(CAGR)

Winner

VRTX

+17.19%

MFG

+14.27%

Max(CAGR)

Winner

VRTX

+14.03%

MFG

+0.30%

VRTX vs MFG - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	VRTX	MFG
2026	-4.93%	+17.27%
2025	+11.73%	+54.62%
2024	-2.00%	+48.52%
2023	+42.26%	+25.67%
2022	+29.77%	+15.29%
2021	-4.28%	+2.43%
2020	+7.70%	-15.11%
2019	+33.44%	+1.31%
2018	+8.37%	-18.03%
2017	+100.11%	+2.64%
2016	-40.05%	-6.13%
2015	+2.24%	+23.94%
2014	+60.91%	-18.45%
2013	+70.22%	+17.89%
2012	+30.00%	+38.55%
2011	-7.72%	-25.70%
2010	-20.82%	+8.69%
2009	+39.62%	-37.15%
2008	+31.23%	-37.49%
2007	-37.05%	-33.09%
2006	+34.12%	-3.03%
2005	+170.21%	N/A
2004	+0.67%	N/A
2003	-36.74%	N/A
2002	-35.41%	N/A
2001	-61.05%	N/A
2000	+281.33%	N/A
1999	+32.38%	N/A

VRTX vs MFG Drawdown Comparison

The maximum drawdown for VRTX was -91.77%, occurring on Nov 11, 2003. Recovery took 3434 trading sessions.

The maximum drawdown for MFG was -80.58%, occurring on Mar 16, 2020. Recovery took 4776 trading sessions.

The current VRTX drawdown is -16.82%. The current MFG drawdown is -13.88%.

Rank	VRTX	MFG
#1	-91.77% Nov 2, 2000 - Jul 2, 2014	-80.58% Jan 22, 2007 - Jan 14, 2026
#2	-55.25% Mar 6, 2000 - Jun 16, 2000	-24.78% Feb 11, 2026 - Mar 20, 2026
#3	-49.10% Aug 19, 2015 - Jul 19, 2017	-7.78% Nov 14, 2006 - Dec 4, 2006
#4	-41.60% Jul 20, 2020 - Aug 15, 2022	-5.33% Dec 15, 2006 - Jan 22, 2007
#5	-29.08% Sep 28, 2000 - Oct 25, 2000	-4.02% Dec 4, 2006 - Dec 15, 2006
#6	-29.07% Nov 8, 2024 - Aug 8, 2025	-3.83% Nov 8, 2006 - Nov 14, 2006
#7	-22.82% Jul 12, 2000 - Aug 16, 2000	-3.12% Feb 4, 2026 - Feb 6, 2026
#8	-21.18% Sep 28, 2018 - Jan 18, 2019	-2.56% Jan 16, 2026 - Jan 27, 2026
#9	-19.52% Jan 21, 2000 - Feb 7, 2000	-0.58% Jan 27, 2026 - Feb 2, 2026
#10	-19.39% Feb 11, 2020 - Apr 6, 2020	N/A
#11	-17.73% Mar 12, 2018 - Jul 12, 2018	N/A
#12	-17.36% Jul 24, 2017 - Jan 23, 2018	N/A
#13	-15.45% Jan 18, 2019 - Oct 29, 2019	N/A
#14	-15.26% Jan 22, 2015 - Mar 16, 2015	N/A
#15	-14.46% Jul 11, 2014 - Sep 19, 2014	N/A