VRTX vs SYK

Comparison between Vertex Pharmaceuticals Inc (VRTX, Company) and Stryker Corp (SYK, Company).

Both VRTX and SYK are from the Healthcare sector.

5-Year PerformanceVRTX has outperformed SYK, delivering a return of +19.5% compared to +4.1%

VRTX vs SYK - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	VRTX(COMPANY)	SYK(COMPANY)
Market Cap	$117B	$115B
Max Drawdown	91.77%	59.22%
Sharpe Ratio	0.12	-0.98
5Y Beta	0.50	0.60
Industry	Biotechnology	Medical Devices
P/E Ratio	26.93	36.64
Forward P/E	23.87	20.70
Dividend Yield	N/A	1.12%
5Y Dividends CAGR	N/A	12.17%
5Y EPS CAGR	9.89%	9.70%
Debt to Equity	0.00%	64.07%
Free Cash Flow Yield	3.18%	3.96%

Market Cap

Winner

VRTX

$117B

SYK

$115B

Max Drawdown

VRTX

91.77%

Winner

SYK

59.22%

Sharpe Ratio

Winner

VRTX

0.12

SYK

-0.98

5Y Beta

Winner

VRTX

0.50

SYK

0.60

Industry

VRTX

Biotechnology

SYK

Medical Devices

P/E Ratio

Winner

VRTX

26.93

SYK

36.64

Forward P/E

VRTX

23.87

Winner

SYK

20.70

Dividend Yield

VRTX

N/A

SYK

1.12%

5Y Dividends CAGR

VRTX

N/A

SYK

12.17%

5Y EPS CAGR

Winner

VRTX

9.89%

SYK

9.70%

Debt to Equity

Winner

VRTX

0.00%

SYK

64.07%

Free Cash Flow Yield

VRTX

3.18%

Winner

SYK

3.96%

VRTX vs SYK - Historical Returns

Returns include dividend reinvestment.

Period	VRTX	SYK
1 month	+5.13%	-3.86%
3 months	-0.76%	-13.51%
6 months	+2.11%	-14.15%
1 year	+3.85%	-18.57%
5 years(CAGR)	+19.50%	+4.08%
10 years(CAGR)	+18.13%	+11.39%
Max(CAGR)	+14.25%	+12.76%

Winner

VRTX

+5.13%

SYK

-3.86%

Winner

VRTX

-0.76%

SYK

-13.51%

Winner

VRTX

+2.11%

SYK

-14.15%

Winner

VRTX

+3.85%

SYK

-18.57%

5Y(CAGR)

Winner

VRTX

+19.50%

SYK

+4.08%

10Y(CAGR)

Winner

VRTX

+18.13%

SYK

+11.39%

Max(CAGR)

Winner

VRTX

+14.25%

SYK

+12.76%

VRTX vs SYK - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	VRTX	SYK
2026	+1.52%	-13.28%
2025	+11.73%	-1.12%
2024	-2.00%	+22.66%
2023	+42.26%	+23.01%
2022	+29.77%	-7.77%
2021	-4.28%	+13.00%
2020	+7.70%	+17.86%
2019	+33.44%	+37.30%
2018	+8.37%	+0.45%
2017	+100.11%	+31.25%
2016	-40.05%	+34.91%
2015	+2.24%	+0.38%
2014	+60.91%	+28.28%
2013	+70.22%	+36.65%
2012	+30.00%	+9.11%
2011	-7.72%	-7.64%
2010	-20.82%	+4.18%
2009	+39.62%	+22.54%
2008	+31.23%	-45.17%
2007	-37.05%	+36.15%
2006	+34.12%	+24.06%
2005	+170.21%	-7.69%
2004	+0.67%	+15.43%
2003	-36.74%	+25.19%
2002	-35.41%	+17.50%
2001	-61.05%	+20.31%
2000	+281.33%	+48.20%
1999	+32.38%	+11.72%

VRTX vs SYK Drawdown Comparison

The maximum drawdown for VRTX was -91.77%, occurring on Nov 11, 2003. Recovery took 3434 trading sessions.

The maximum drawdown for SYK was -58.62%, occurring on Mar 9, 2009. Recovery took 1441 trading sessions.

The current VRTX drawdown is -11.18%. The current SYK drawdown is -24.82%.

Rank	VRTX	SYK
#1	-91.77% Nov 2, 2000 - Jul 2, 2014	-58.62% Dec 26, 2007 - Sep 17, 2013
#2	-55.25% Mar 6, 2000 - Jun 16, 2000	-43.80% Feb 19, 2020 - Oct 12, 2020
#3	-49.10% Aug 19, 2015 - Jul 19, 2017	-35.95% Jan 19, 2000 - Jun 14, 2000
#4	-41.60% Jul 20, 2020 - Aug 15, 2022	-31.68% Sep 8, 2021 - Feb 1, 2023
#5	-29.08% Sep 28, 2000 - Oct 25, 2000	-30.45% Jul 7, 2004 - Jan 9, 2007
#6	-29.07% Nov 8, 2024 - Aug 8, 2025	-29.45% Jul 25, 2025 - May 11, 2026
#7	-22.82% Jul 12, 2000 - Aug 16, 2000	-26.85% Feb 27, 2002 - Oct 10, 2002
#8	-21.18% Sep 28, 2018 - Jan 18, 2019	-24.26% Jul 27, 2001 - Feb 27, 2002
#9	-19.52% Jan 21, 2000 - Feb 7, 2000	-19.74% Jul 26, 2000 - Nov 2, 2000
#10	-19.39% Feb 11, 2020 - Apr 6, 2020	-18.90% Jun 6, 2018 - Jan 30, 2019
#11	-17.73% Mar 12, 2018 - Jul 12, 2018	-18.18% Dec 6, 2000 - Feb 23, 2001
#12	-17.36% Jul 24, 2017 - Jan 23, 2018	-16.57% Jun 30, 2023 - Jan 10, 2024
#13	-15.45% Jan 18, 2019 - Oct 29, 2019	-15.79% Mar 1, 2001 - Apr 25, 2001
#14	-15.26% Jan 22, 2015 - Mar 16, 2015	-15.61% Aug 19, 2015 - Mar 10, 2016
#15	-14.46% Jul 11, 2014 - Sep 19, 2014	-15.45% Jan 27, 2025 - Jul 23, 2025