VRTX vs SPY
Comparison between Vertex Pharmaceuticals Inc (VRTX, Company) and SPDR S&P 500 ETF Trust (SPY, ETF).
5-Year PerformanceVRTX has outperformed SPY, delivering a return of +14.9% compared to +13.3%
VRTX vs SPY - Performance Comparison
Key Characteristics
Financial metrics and valuation ratios
Market Cap / Net Assets
VRTX
$109B
Winner
SPY
$652B
Expense Ratio
VRTX
N/A
SPY
0.09%
Max Drawdown
VRTX
91.77%
Winner
SPY
56.47%
Sharpe Ratio
VRTX
0.04
Winner
SPY
2.07
5Y Beta
Winner
VRTX
0.51
SPY
1.00
Industry
VRTX
Biotechnology
SPY
N/A
P/E Ratio
Winner
VRTX
25.09
SPY
28.24
Forward P/E
VRTX
22.57
Winner
SPY
21.85
PEG Ratio
VRTX
2.11
SPY
N/A
5Y Dividends CAGR
VRTX
N/A
SPY
5.43%
5Y EPS CAGR
VRTX
9.89%
Winner
SPY
25.79%
Debt to Equity
Winner
VRTX
0.00%
SPY
22.35%
Free Cash Flow Yield
VRTX
3.41%
SPY
N/A
P/S Ratio
VRTX
8.88
Winner
SPY
3.55
P/B Ratio
VRTX
5.65
Winner
SPY
5.29
VRTX vs SPY - Historical Returns
Returns include dividend reinvestment.
1M
VRTX
-3.18%
Winner
SPY
+9.11%
3M
VRTX
-8.72%
Winner
SPY
+6.59%
6M
VRTX
+4.97%
Winner
SPY
+10.56%
1Y
VRTX
+0.05%
Winner
SPY
+32.04%
5Y(CAGR)
Winner
VRTX
+14.85%
SPY
+13.35%
10Y(CAGR)
Winner
VRTX
+17.19%
SPY
+15.49%
Max(CAGR)
Winner
VRTX
+14.03%
SPY
+8.50%
VRTX vs SPY - Annual Returns (1999 - 2026)
Returns include dividend reinvestment.
| Year | VRTX | SPY |
|---|---|---|
| 2026 | -4.93% | +8.27% |
| 2025 | +11.73% | +18.00% |
| 2024 | -2.00% | +25.59% |
| 2023 | +42.26% | +26.72% |
| 2022 | +29.77% | -18.64% |
| 2021 | -4.28% | +30.52% |
| 2020 | +7.70% | +17.28% |
| 2019 | +33.44% | +31.09% |
| 2018 | +8.37% | -5.24% |
| 2017 | +100.11% | +20.78% |
| 2016 | -40.05% | +13.59% |
| 2015 | +2.24% | +1.31% |
| 2014 | +60.91% | +14.56% |
| 2013 | +70.22% | +29.00% |
| 2012 | +30.00% | +14.17% |
| 2011 | -7.72% | +0.85% |
| 2010 | -20.82% | +13.14% |
| 2009 | +39.62% | +22.67% |
| 2008 | +31.23% | -36.25% |
| 2007 | -37.05% | +5.32% |
| 2006 | +34.12% | +13.85% |
| 2005 | +170.21% | +5.32% |
| 2004 | +0.67% | +10.75% |
| 2003 | -36.74% | +24.18% |
| 2002 | -35.41% | -22.42% |
| 2001 | -61.05% | -10.13% |
| 2000 | +281.33% | -8.84% |
| 1999 | +32.38% | +8.61% |
VRTX vs SPY Drawdown Comparison
The maximum drawdown for VRTX was -91.77%, occurring on Nov 11, 2003. Recovery took 3434 trading sessions.
The maximum drawdown for SPY was -55.20%, occurring on Mar 9, 2009. Recovery took 1224 trading sessions.
The current VRTX drawdown is -16.82%.
| Rank | VRTX | SPY |
|---|---|---|
| #1 | -91.77% Nov 2, 2000 - Jul 2, 2014 | -55.20% Oct 9, 2007 - Aug 16, 2012 |
| #2 | -55.25% Mar 6, 2000 - Jun 16, 2000 | -47.50% Mar 24, 2000 - Oct 26, 2006 |
| #3 | -49.10% Aug 19, 2015 - Jul 19, 2017 | -33.70% Feb 19, 2020 - Aug 10, 2020 |
| #4 | -41.60% Jul 20, 2020 - Aug 15, 2022 | -24.50% Jan 3, 2022 - Dec 13, 2023 |
| #5 | -29.08% Sep 28, 2000 - Oct 25, 2000 | -19.34% Sep 20, 2018 - Apr 12, 2019 |
| #6 | -29.07% Nov 8, 2024 - Aug 8, 2025 | -18.76% Feb 19, 2025 - Jun 26, 2025 |
| #7 | -22.82% Jul 12, 2000 - Aug 16, 2000 | -13.02% Jul 20, 2015 - Apr 18, 2016 |
| #8 | -21.18% Sep 28, 2018 - Jan 18, 2019 | -10.10% Jan 26, 2018 - Aug 6, 2018 |
| #9 | -19.52% Jan 21, 2000 - Feb 7, 2000 | -9.44% Sep 2, 2020 - Nov 11, 2020 |
| #10 | -19.39% Feb 11, 2020 - Apr 6, 2020 | -9.30% Jan 19, 2000 - Mar 17, 2000 |
| #11 | -17.73% Mar 12, 2018 - Jul 12, 2018 | -9.05% Jul 19, 2007 - Oct 5, 2007 |
| #12 | -17.36% Jul 24, 2017 - Jan 23, 2018 | -8.88% Jan 27, 2026 - Apr 14, 2026 |
| #13 | -15.45% Jan 18, 2019 - Oct 29, 2019 | -8.41% Jul 16, 2024 - Sep 19, 2024 |
| #14 | -15.26% Jan 22, 2015 - Mar 16, 2015 | -7.35% Sep 14, 2012 - Jan 2, 2013 |
| #15 | -14.46% Jul 11, 2014 - Sep 19, 2014 | -7.27% Sep 18, 2014 - Oct 31, 2014 |
Correlation
Correlation between VRTX and SPY is 0.97 which considered as a very strong positive correlation - the stocks move almost identically together.
0.97
-101
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