IONS vs PEN

Comparison between Ionis Pharmaceuticals Inc (IONS, Company) and Penumbra Inc (PEN, Company).

Both IONS and PEN are from the Healthcare sector.

5-Year PerformanceIONS has outperformed PEN, delivering a return of +15.7% compared to +3.5%

IONS vs PEN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	IONS(COMPANY)	PEN(COMPANY)
Market Cap	$13B	$13B
Max Drawdown	91.72%	62.64%
Sharpe Ratio	1.90	0.37
5Y Beta	0.75	0.54
Industry	Biotechnology	Medical Devices
P/E Ratio	-72.93	77.46
Forward P/E	96.15	62.89
PEG Ratio	-1.54	0.73
5Y EPS CAGR	-21.44%	46.16%
Debt to Equity	88.01%	0.00%
Free Cash Flow Yield	-7.62%	1.67%
P/S Ratio	12.00	9.08
P/B Ratio	25.84	8.94

Market Cap

Winner

IONS

$13B

PEN

$13B

Max Drawdown

IONS

91.72%

Winner

PEN

62.64%

Sharpe Ratio

Winner

IONS

1.90

PEN

0.37

5Y Beta

IONS

0.75

Winner

PEN

0.54

Industry

IONS

Biotechnology

PEN

Medical Devices

P/E Ratio

Winner

IONS

-72.93

PEN

77.46

Forward P/E

IONS

96.15

Winner

PEN

62.89

PEG Ratio

Winner

IONS

-1.54

PEN

0.73

5Y EPS CAGR

IONS

-21.44%

Winner

PEN

46.16%

Debt to Equity

IONS

88.01%

Winner

PEN

0.00%

Free Cash Flow Yield

IONS

-7.62%

Winner

PEN

1.67%

P/S Ratio

IONS

12.00

Winner

PEN

9.08

P/B Ratio

IONS

25.84

Winner

PEN

8.94

IONS vs PEN - Historical Returns

Returns include dividend reinvestment.

Period	IONS	PEN
1 month	+0.97%	-2.67%
3 months	-10.71%	-4.96%
6 months	+2.94%	+21.05%
1 year	+131.18%	+11.60%
5 years(CAGR)	+15.68%	+3.49%
10 years(CAGR)	+8.22%	+19.66%
Max(CAGR)	+7.64%	+21.31%

Winner

IONS

+0.97%

PEN

-2.67%

IONS

-10.71%

Winner

PEN

-4.96%

IONS

+2.94%

Winner

PEN

+21.05%

Winner

IONS

+131.18%

PEN

+11.60%

5Y(CAGR)

Winner

IONS

+15.68%

PEN

+3.49%

10Y(CAGR)

IONS

+8.22%

Winner

PEN

+19.66%

Max(CAGR)

IONS

+7.64%

Winner

PEN

+21.31%

IONS vs PEN - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	IONS	PEN
2026	-4.97%	+4.14%
2025	+128.05%	+29.55%
2024	-33.88%	-2.98%
2023	+34.62%	+13.72%
2022	+15.86%	-21.66%
2021	-46.41%	+63.62%
2020	-7.14%	+6.84%
2019	+12.35%	+33.48%
2018	+9.77%	+35.25%
2017	+6.25%	+46.92%
2016	-22.45%	+14.52%
2015	+0.58%	+30.29%
2014	+54.85%	N/A
2013	+268.21%	N/A
2012	+44.00%	N/A
2011	-29.93%	N/A
2010	-10.20%	N/A
2009	-23.22%	N/A
2008	-7.80%	N/A
2007	+44.10%	N/A
2006	+111.81%	N/A
2005	-9.66%	N/A
2004	-13.36%	N/A
2003	-4.97%	N/A
2002	-68.69%	N/A
2001	+130.55%	N/A
2000	+77.49%	N/A
1999	-44.34%	N/A

IONS vs PEN Drawdown Comparison

The maximum drawdown for IONS was -91.43%, occurring on Mar 18, 2003. Recovery took 3357 trading sessions.

The maximum drawdown for PEN was -62.64%, occurring on Jun 16, 2022. Recovery took 511 trading sessions.

The current IONS drawdown is -12.47%. The current PEN drawdown is -10.34%.

Rank	IONS	PEN
#1	-91.43% Mar 6, 2000 - Jul 11, 2013	-62.64% Apr 28, 2021 - May 9, 2023
#2	-73.25% Mar 19, 2015 - Mar 14, 2019	-52.44% Jun 30, 2023 - Jan 15, 2026
#3	-70.39% Apr 8, 2019 - Feb 6, 2026	-35.86% Nov 12, 2020 - Feb 9, 2021
#4	-68.14% Dec 2, 1999 - Mar 1, 2000	-35.83% Feb 19, 2020 - Jul 8, 2020
#5	-61.05% Feb 21, 2014 - Dec 10, 2014	-31.65% Jun 6, 2018 - Jun 14, 2019
#6	-28.35% Jul 12, 2013 - Sep 19, 2013	-28.12% Jul 24, 2019 - Feb 11, 2020
#7	-20.89% Sep 23, 2013 - Nov 27, 2013	-26.97% Nov 9, 2017 - Mar 6, 2018
#8	-19.78% Jan 12, 2015 - Mar 19, 2015	-26.12% Sep 22, 2016 - Feb 21, 2017
#9	-19.45% Feb 6, 2026 - Mar 24, 2026	-24.61% Jan 4, 2016 - Jun 6, 2016
#10	-11.84% Dec 12, 2014 - Dec 19, 2014	-21.70% Aug 13, 2020 - Oct 27, 2020
#11	-11.49% Dec 19, 2014 - Jan 5, 2015	-13.42% Dec 1, 2015 - Dec 11, 2015
#12	-8.95% Jan 31, 2014 - Feb 13, 2014	-12.79% Mar 1, 2021 - Apr 23, 2021
#13	-8.58% Nov 11, 1999 - Nov 17, 1999	-12.45% Oct 8, 2015 - Nov 13, 2015
#14	-7.67% Jan 22, 2014 - Jan 31, 2014	-11.94% Jun 23, 2017 - Oct 2, 2017
#15	-7.49% Dec 23, 2013 - Jan 8, 2014	-11.02% Mar 21, 2018 - Apr 27, 2018