ALKS vs PTGX

Comparison between Alkermes plc (ALKS, Company) and Protagonist Therapeutics Inc (PTGX, Company).

Both ALKS and PTGX are from the Healthcare sector.

5-Year PerformancePTGX has outperformed ALKS, delivering a return of +23.2% compared to +15.4%

ALKS vs PTGX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	ALKS(COMPANY)	PTGX(COMPANY)
Market Cap	$9.04B	$9B
Max Drawdown	96.14%	85.79%
Sharpe Ratio	1.42	1.98
5Y Beta	0.61	0.24
Industry	Drug Manufacturers - Specialty & Generic	Biotechnology
P/E Ratio	58.53	-76.12
Forward P/E	142.86	29.15
PEG Ratio	1.96	0.00
5Y EPS CAGR	N/A	1.43%
Debt to Equity	86.23%	0.00%
Free Cash Flow Yield	2.45%	-1.31%
P/S Ratio	5.79	121.63
P/B Ratio	5.19	13.82

Market Cap

Winner

ALKS

$9.04B

PTGX

$9B

Max Drawdown

ALKS

96.14%

Winner

PTGX

85.79%

Sharpe Ratio

ALKS

1.42

Winner

PTGX

1.98

5Y Beta

ALKS

0.61

Winner

PTGX

0.24

Industry

ALKS

Drug Manufacturers - Specialty & Generic

PTGX

Biotechnology

P/E Ratio

ALKS

58.53

Winner

PTGX

-76.12

Forward P/E

ALKS

142.86

Winner

PTGX

29.15

PEG Ratio

ALKS

1.96

Winner

PTGX

0.00

5Y EPS CAGR

ALKS

N/A

PTGX

1.43%

Debt to Equity

ALKS

86.23%

Winner

PTGX

0.00%

Free Cash Flow Yield

Winner

ALKS

2.45%

PTGX

-1.31%

P/S Ratio

Winner

ALKS

5.79

PTGX

121.63

P/B Ratio

Winner

ALKS

5.19

PTGX

13.82

ALKS vs PTGX - Historical Returns

Returns include dividend reinvestment.

Period	ALKS	PTGX
1 month	+18.48%	+24.25%
3 months	+55.70%	+32.99%
6 months	+75.12%	+63.82%
1 year	+70.52%	+148.78%
5 years(CAGR)	+15.41%	+23.25%
10 years(CAGR)	+0.55%	+27.64%
Max(CAGR)	+4.00%	+27.64%

ALKS

+18.48%

Winner

PTGX

+24.25%

Winner

ALKS

+55.70%

PTGX

+32.99%

Winner

ALKS

+75.12%

PTGX

+63.82%

ALKS

+70.52%

Winner

PTGX

+148.78%

5Y(CAGR)

ALKS

+15.41%

Winner

PTGX

+23.25%

10Y(CAGR)

ALKS

+0.55%

Winner

PTGX

+27.64%

Max(CAGR)

ALKS

+4.00%

Winner

PTGX

+27.64%

ALKS vs PTGX - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	ALKS	PTGX
2026	+83.79%	+50.75%
2025	-2.68%	+124.06%
2024	+0.49%	+64.82%
2023	+7.23%	+112.71%
2022	+8.20%	-69.11%
2021	+17.83%	+74.49%
2020	+0.96%	+190.91%
2019	-29.92%	+2.32%
2018	-46.56%	-68.18%
2017	-2.44%	-1.79%
2016	-25.72%	+87.95%
2015	+36.30%	N/A
2014	+45.53%	N/A
2013	+110.89%	N/A
2012	+6.81%	N/A
2011	+38.33%	N/A
2010	+26.47%	N/A
2009	-12.14%	N/A
2008	-29.47%	N/A
2007	+19.10%	N/A
2006	-34.84%	N/A
2005	+36.47%	N/A
2004	+0.86%	N/A
2003	+102.70%	N/A
2002	-75.65%	N/A
2001	-4.60%	N/A
2000	+27.74%	N/A
1999	+34.60%	N/A

ALKS vs PTGX Drawdown Comparison

The maximum drawdown for ALKS was -96.14%, occurring on Jul 11, 2002. This drawdown has not yet recovered.

The maximum drawdown for PTGX was -85.79%, occurring on Jun 13, 2022. Recovery took 882 trading sessions.

The current ALKS drawdown is -47.03%. The current PTGX drawdown is -6.70%.

Rank	ALKS	PTGX
#1	-96.14% Mar 1, 2000 - Jul 11, 2002	-85.79% Sep 1, 2021 - Mar 10, 2025
#2	-14.44% Jan 20, 2000 - Feb 3, 2000	-82.13% Dec 5, 2016 - Feb 16, 2021
#3	-12.68% Nov 26, 1999 - Dec 17, 1999	-31.58% Mar 11, 2025 - Aug 27, 2025
#4	-10.50% Dec 23, 1999 - Jan 7, 2000	-20.33% Oct 17, 2016 - Nov 10, 2016
#5	-9.45% Feb 18, 2000 - Feb 29, 2000	-19.04% Mar 19, 2021 - May 18, 2021
#6	-4.37% Nov 11, 1999 - Nov 16, 1999	-16.38% Dec 12, 2025 - Mar 9, 2026
#7	-4.12% Feb 11, 2000 - Feb 16, 2000	-15.52% Oct 10, 2025 - Nov 24, 2025
#8	-3.50% Jan 10, 2000 - Jan 13, 2000	-12.77% Feb 16, 2021 - Mar 2, 2021
#9	-3.33% Feb 8, 2000 - Feb 10, 2000	-12.03% Apr 17, 2026 - Jun 11, 2026
#10	-2.86% Nov 16, 1999 - Nov 22, 1999	-11.53% Aug 19, 2016 - Aug 31, 2016
#11	-2.52% Nov 2, 1999 - Nov 5, 1999	-9.62% Jun 8, 2021 - Jun 11, 2021
#12	-2.49% Nov 22, 1999 - Nov 26, 1999	-8.53% Aug 27, 2025 - Sep 18, 2025
#13	-0.62% Nov 9, 1999 - Nov 11, 1999	-7.43% Mar 31, 2026 - Apr 15, 2026
#14	-0.49% Dec 21, 1999 - Dec 23, 1999	-7.20% Jun 14, 2021 - Jun 16, 2021
#15	N/A	-6.70% Jul 7, 2026 - Jul 10, 2026