TXMD vs DYAI

Comparison between TherapeuticsMD Inc (TXMD, Company) and Dyadic International Inc DE (DYAI, Company).

Both TXMD and DYAI are from the Healthcare sector.

5-Year PerformanceDYAI has outperformed TXMD, delivering a return of -24.4% compared to -48.1%

TXMD vs DYAI - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	TXMD(COMPANY)	DYAI(COMPANY)
Market Cap	$26M	$27M
Max Drawdown	99.89%	93.42%
Sharpe Ratio	1.31	0.18
5Y Beta	0.63	0.48
Industry	Drug Manufacturers - Specialty & Generic	Biotechnology
P/E Ratio	146.78	-3.46
Forward P/E	2.33	15.82
PEG Ratio	N/A	-0.45
5Y EPS CAGR	N/A	-7.16%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	N/A	-21.49%
P/S Ratio	N/A	6.46
P/B Ratio	N/A	21.01

Market Cap

TXMD

$26M

Winner

DYAI

$27M

Max Drawdown

TXMD

99.89%

Winner

DYAI

93.42%

Sharpe Ratio

Winner

TXMD

1.31

DYAI

0.18

5Y Beta

TXMD

0.63

Winner

DYAI

0.48

Industry

TXMD

Drug Manufacturers - Specialty & Generic

DYAI

Biotechnology

P/E Ratio

TXMD

146.78

Winner

DYAI

-3.46

Forward P/E

Winner

TXMD

2.33

DYAI

15.82

PEG Ratio

TXMD

N/A

DYAI

-0.45

5Y EPS CAGR

TXMD

N/A

DYAI

-7.16%

Debt to Equity

TXMD

0.00%

DYAI

0.00%

Free Cash Flow Yield

TXMD

N/A

DYAI

-21.49%

P/S Ratio

TXMD

N/A

DYAI

6.46

P/B Ratio

TXMD

N/A

DYAI

21.01

TXMD vs DYAI - Historical Returns

Returns include dividend reinvestment.

Period	TXMD	DYAI
1 month	+12.38%	+17.84%
3 months	+1.79%	+5.80%
6 months	+35.93%	-5.39%
1 year	+102.68%	-7.76%
5 years(CAGR)	-48.14%	-24.42%
10 years(CAGR)	-40.67%	-6.60%
Max(CAGR)	-9.38%	-6.89%

TXMD

+12.38%

Winner

DYAI

+17.84%

TXMD

+1.79%

Winner

DYAI

+5.80%

Winner

TXMD

+35.93%

DYAI

-5.39%

Winner

TXMD

+102.68%

DYAI

-7.76%

5Y(CAGR)

TXMD

-48.14%

Winner

DYAI

-24.42%

10Y(CAGR)

TXMD

-40.67%

Winner

DYAI

-6.60%

Max(CAGR)

TXMD

-9.38%

Winner

DYAI

-6.89%

TXMD vs DYAI - Annual Returns (2003 - 2026)

Returns include dividend reinvestment.

Year	TXMD	DYAI
2026	+37.58%	-9.71%
2025	+3.82%	-45.98%
2024	-63.09%	+10.06%
2023	-64.00%	+16.67%
2022	-71.60%	-74.43%
2021	-71.33%	-12.40%
2020	-50.41%	+2.09%
2019	-37.63%	+183.06%
2018	-39.23%	+35.00%
2017	+1.17%	-16.77%
2016	-41.18%	-7.26%
2015	+136.22%	N/A
2014	-10.82%	N/A
2013	+60.31%	N/A
2012	+82.35%	N/A
2011	+4738.71%	N/A
2010	-98.00%	N/A
2009	+160.00%	N/A
2008	+48.52%	N/A
2007	-59.44%	N/A
2006	+33.33%	N/A
2005	+48.52%	N/A
2004	-8.18%	N/A
2003	-12.00%	N/A

TXMD vs DYAI Drawdown Comparison

The maximum drawdown for TXMD was -99.89%, occurring on Aug 24, 2011. Recovery took 1071 trading sessions.

The maximum drawdown for DYAI was -93.42%, occurring on Jun 9, 2026. This drawdown has not yet recovered.

The current TXMD drawdown is -99.59%. The current DYAI drawdown is -91.73%.

Rank	TXMD	DYAI
#1	-99.89% Jul 27, 2009 - Oct 25, 2013	-93.42% Jun 22, 2020 - Jun 9, 2026
#2	-99.87% Dec 29, 2015 - Mar 14, 2025	-62.88% Jun 19, 2019 - Jun 10, 2020
#3	-85.43% Mar 1, 2007 - Jul 21, 2009	-30.94% Jan 9, 2017 - Oct 4, 2018
#4	-80.00% Dec 11, 2003 - Jun 29, 2004	-25.23% Oct 5, 2018 - Feb 14, 2019
#5	-56.96% Mar 18, 2014 - Jun 5, 2015	-21.79% Jan 4, 2016 - Jan 6, 2017
#6	-53.02% Nov 24, 2004 - Apr 4, 2006	-13.04% Jun 10, 2020 - Jun 12, 2020
#7	-36.59% Jul 23, 2015 - Dec 8, 2015	-12.56% May 22, 2019 - Jun 3, 2019
#8	-31.82% Apr 4, 2006 - Dec 20, 2006	-12.36% May 10, 2019 - May 22, 2019
#9	-27.27% Feb 9, 2007 - Mar 1, 2007	-9.44% Apr 26, 2019 - May 9, 2019
#10	-25.10% Oct 28, 2013 - Dec 24, 2013	-9.25% Jun 6, 2019 - Jun 17, 2019
#11	-19.60% Jan 9, 2007 - Feb 9, 2007	-8.70% Apr 1, 2019 - Apr 15, 2019
#12	-11.11% Dec 20, 2006 - Jan 3, 2007	-6.68% Jun 15, 2020 - Jun 19, 2020
#13	-10.98% Jan 30, 2014 - Feb 27, 2014	-4.49% Apr 15, 2019 - Apr 26, 2019
#14	-8.69% Jun 5, 2015 - Jul 1, 2015	-4.20% Feb 25, 2019 - Mar 13, 2019
#15	-7.76% Dec 26, 2013 - Jan 10, 2014	-1.74% Mar 13, 2019 - Mar 18, 2019