SYRE vs OUT

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Outfront Media Inc (OUT, Company).

SYRE is from the Healthcare sector, while OUT is from the Real Estate sector.

5-Year PerformanceOUT has outperformed SYRE, delivering a return of +13.5% compared to -16.9%

SYRE vs OUT - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	OUT(COMPANY)
Market Cap	$5.67B	$5.64B
Max Drawdown	99.11%	77.27%
Sharpe Ratio	2.60	2.37
5Y Beta	1.75	1.19
Industry	Biotechnology	Reit - Specialty
P/E Ratio	-29.14	30.12
Forward P/E	N/A	24.51
PEG Ratio	N/A	0.25
Dividend Yield	N/A	3.75%
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	390.47%
Free Cash Flow Yield	-3.27%	4.49%

Market Cap

Winner

SYRE

$5.67B

OUT

$5.64B

Max Drawdown

SYRE

99.11%

Winner

OUT

77.27%

Sharpe Ratio

Winner

SYRE

2.60

OUT

2.37

5Y Beta

SYRE

1.75

Winner

OUT

1.19

Industry

SYRE

Biotechnology

OUT

Reit - Specialty

P/E Ratio

Winner

SYRE

-29.14

OUT

30.12

Forward P/E

SYRE

N/A

OUT

24.51

PEG Ratio

SYRE

N/A

OUT

0.25

Dividend Yield

SYRE

N/A

OUT

3.75%

5Y EPS CAGR

SYRE

-2.15%

OUT

N/A

Debt to Equity

Winner

SYRE

0.00%

OUT

390.47%

Free Cash Flow Yield

SYRE

-3.27%

Winner

OUT

4.49%

SYRE vs OUT - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	OUT
1 month	-2.00%	+8.24%
3 months	+66.44%	+26.89%
6 months	+206.43%	+53.38%
1 year	+367.01%	+113.00%
5 years(CAGR)	-16.95%	+13.55%
10 years(CAGR)	-9.09%	+9.91%
Max(CAGR)	-11.38%	+7.73%

SYRE

-2.00%

Winner

OUT

+8.24%

Winner

SYRE

+66.44%

OUT

+26.89%

Winner

SYRE

+206.43%

OUT

+53.38%

Winner

SYRE

+367.01%

OUT

+113.00%

5Y(CAGR)

SYRE

-16.95%

Winner

OUT

+13.55%

10Y(CAGR)

SYRE

-9.09%

Winner

OUT

+9.91%

Max(CAGR)

SYRE

-11.38%

Winner

OUT

+7.73%

SYRE vs OUT - Annual Returns (2014 - 2026)

Returns include dividend reinvestment.

Year	SYRE	OUT
2026	+135.19%	+40.00%
2025	+37.36%	+43.04%
2024	+8.79%	+35.65%
2023	+104.27%	-6.81%
2022	-90.57%	-35.65%
2021	-44.51%	+45.74%
2020	+1.55%	-25.82%
2019	-4.98%	+56.70%
2018	+39.22%	-15.95%
2017	+18.38%	-2.10%
2016	-55.48%	+21.09%
2015	N/A	-13.77%
2014	N/A	+10.12%

SYRE vs OUT Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for OUT was -73.80%, occurring on Mar 20, 2020. Recovery took 1460 trading sessions.

The current SYRE drawdown is -76.01%. The current OUT drawdown is -3.10%.

Rank	SYRE	OUT
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-73.80% Feb 7, 2020 - Nov 28, 2025
#2	N/A	-38.39% Mar 20, 2015 - Apr 12, 2019
#3	N/A	-17.93% Jun 26, 2014 - Feb 13, 2015
#4	N/A	-12.37% Oct 4, 2019 - Jan 10, 2020
#5	N/A	-11.24% Mar 5, 2026 - Apr 9, 2026
#6	N/A	-7.87% Aug 19, 2019 - Sep 20, 2019
#7	N/A	-7.67% Apr 2, 2014 - Apr 16, 2014
#8	N/A	-7.05% May 8, 2026 - May 15, 2026
#9	N/A	-6.88% Feb 6, 2026 - Feb 26, 2026
#10	N/A	-5.46% Aug 8, 2019 - Aug 19, 2019
#11	N/A	-5.36% Apr 16, 2014 - May 9, 2014
#12	N/A	-5.11% Jun 10, 2019 - Jun 18, 2019
#13	N/A	-5.03% Jun 24, 2019 - Jul 23, 2019
#14	N/A	-4.93% Jul 24, 2019 - Aug 8, 2019
#15	N/A	-4.10% Jan 21, 2026 - Feb 3, 2026