SYRE vs NICE

Comparison between Spyre Therapeutics Inc (SYRE, Company) and NICE Ltd (NICE, Company).

SYRE is from the Healthcare sector, while NICE is from the Technology sector.

5-Year PerformanceNICE has outperformed SYRE, delivering a return of -16.0% compared to -16.9%

SYRE vs NICE - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	NICE(COMPANY)
Market Cap	$5.67B	$5.67B
Max Drawdown	99.11%	93.23%
Sharpe Ratio	2.60	-0.97
5Y Beta	1.75	0.78
Industry	Biotechnology	Software - Application
P/E Ratio	-29.14	9.26
Forward P/E	N/A	8.10
PEG Ratio	N/A	0.20
5Y EPS CAGR	-2.15%	26.56%
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-3.27%	12.31%

Market Cap

Winner

SYRE

$5.67B

NICE

$5.67B

Max Drawdown

SYRE

99.11%

Winner

NICE

93.23%

Sharpe Ratio

Winner

SYRE

2.60

NICE

-0.97

5Y Beta

SYRE

1.75

Winner

NICE

0.78

Industry

SYRE

Biotechnology

NICE

Software - Application

P/E Ratio

Winner

SYRE

-29.14

NICE

9.26

Forward P/E

SYRE

N/A

NICE

8.10

PEG Ratio

SYRE

N/A

NICE

0.20

5Y EPS CAGR

SYRE

-2.15%

Winner

NICE

26.56%

Debt to Equity

SYRE

0.00%

NICE

0.00%

Free Cash Flow Yield

SYRE

-3.27%

Winner

NICE

12.31%

SYRE vs NICE - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	NICE
1 month	-2.00%	-11.14%
3 months	+66.44%	-20.32%
6 months	+206.43%	-5.85%
1 year	+367.01%	-43.67%
5 years(CAGR)	-16.95%	-15.96%
10 years(CAGR)	-9.09%	+3.92%
Max(CAGR)	-11.38%	+7.17%

Winner

SYRE

-2.00%

NICE

-11.14%

Winner

SYRE

+66.44%

NICE

-20.32%

Winner

SYRE

+206.43%

NICE

-5.85%

Winner

SYRE

+367.01%

NICE

-43.67%

5Y(CAGR)

SYRE

-16.95%

Winner

NICE

-15.96%

10Y(CAGR)

SYRE

-9.09%

Winner

NICE

+3.92%

Max(CAGR)

SYRE

-11.38%

Winner

NICE

+7.17%

SYRE vs NICE - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SYRE	NICE
2026	+135.19%	-16.23%
2025	+37.36%	-33.36%
2024	+8.79%	-11.89%
2023	+104.27%	+4.43%
2022	-90.57%	-34.89%
2021	-44.51%	+8.88%
2020	+1.55%	+78.75%
2019	-4.98%	+45.20%
2018	+39.22%	+17.38%
2017	+18.38%	+34.21%
2016	-55.48%	+22.39%
2015	N/A	+15.20%
2014	N/A	+27.72%
2013	N/A	+18.34%
2012	N/A	-3.32%
2011	N/A	-3.47%
2010	N/A	+10.03%
2009	N/A	+32.54%
2008	N/A	-32.52%
2007	N/A	+14.10%
2006	N/A	+25.42%
2005	N/A	+55.66%
2004	N/A	+30.21%
2003	N/A	+203.59%
2002	N/A	-52.64%
2001	N/A	-2.57%
2000	N/A	-60.47%
1999	N/A	+58.01%

SYRE vs NICE Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for NICE was -93.23%, occurring on Oct 14, 2002. Recovery took 3713 trading sessions.

The current SYRE drawdown is -76.01%. The current NICE drawdown is -70.23%.

Rank	SYRE	NICE
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-93.23% Mar 1, 2000 - Dec 3, 2014
#2	N/A	-72.58% Nov 15, 2021 - May 13, 2026
#3	N/A	-35.23% Feb 20, 2020 - May 22, 2020
#4	N/A	-24.40% Dec 31, 2020 - Jul 22, 2021
#5	N/A	-21.90% Jun 10, 2015 - Jul 28, 2016
#6	N/A	-15.18% Jan 19, 2000 - Feb 8, 2000
#7	N/A	-14.71% Nov 12, 1999 - Dec 9, 1999
#8	N/A	-13.35% Sep 14, 2018 - Feb 25, 2019
#9	N/A	-12.20% Sep 9, 2021 - Nov 11, 2021
#10	N/A	-10.07% Aug 26, 2020 - Oct 12, 2020
#11	N/A	-9.01% Jan 12, 2018 - Feb 21, 2018
#12	N/A	-8.87% Jul 23, 2021 - Aug 24, 2021
#13	N/A	-8.87% Jan 3, 2000 - Jan 10, 2000
#14	N/A	-8.31% Nov 5, 2020 - Dec 16, 2020
#15	N/A	-8.29% Jun 6, 2017 - Sep 18, 2017