SYRE vs OR

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Osisko Gold Royalties Ltd (OR, Company).

SYRE is from the Healthcare sector, while OR is from the Basic Materials sector.

5-Year PerformanceOR has outperformed SYRE, delivering a return of +19.7% compared to -13.3%

SYRE vs OR - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	OR(COMPANY)
Market Cap	$5.92B	$5.94B
Max Drawdown	99.11%	63.70%
Sharpe Ratio	2.48	0.76
5Y Beta	1.78	0.58
Industry	Biotechnology	Gold
P/E Ratio	-30.42	37.08
Forward P/E	N/A	23.81
PEG Ratio	N/A	0.05
Dividend Yield	N/A	0.67%
5Y Dividends CAGR	N/A	11.61%
5Y EPS CAGR	-2.15%	35.27%
Debt to Equity	0.00%	0.31%
Free Cash Flow Yield	-3.14%	1.57%
P/S Ratio	650.22	18.82
P/B Ratio	12.66	4.21

Market Cap

SYRE

$5.92B

Winner

$5.94B

Max Drawdown

SYRE

99.11%

Winner

63.70%

Sharpe Ratio

Winner

SYRE

2.48

0.76

5Y Beta

SYRE

1.78

Winner

0.58

Industry

SYRE

Biotechnology

Gold

P/E Ratio

Winner

SYRE

-30.42

37.08

Forward P/E

SYRE

N/A

23.81

PEG Ratio

SYRE

N/A

0.05

Dividend Yield

SYRE

N/A

0.67%

5Y Dividends CAGR

SYRE

N/A

11.61%

5Y EPS CAGR

SYRE

-2.15%

Winner

35.27%

Debt to Equity

Winner

SYRE

0.00%

0.31%

Free Cash Flow Yield

SYRE

-3.14%

Winner

1.57%

P/S Ratio

SYRE

650.22

Winner

18.82

P/B Ratio

SYRE

12.66

Winner

4.21

SYRE vs OR - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	OR
1 month	+7.66%	-14.59%
3 months	+99.93%	-19.43%
6 months	+140.30%	-5.88%
1 year	+356.18%	+28.93%
5 years(CAGR)	-13.30%	+19.72%
10 years(CAGR)	-6.27%	+11.59%
Max(CAGR)	-10.30%	+13.79%

Winner

SYRE

+7.66%

-14.59%

Winner

SYRE

+99.93%

-19.43%

Winner

SYRE

+140.30%

-5.88%

Winner

SYRE

+356.18%

+28.93%

5Y(CAGR)

SYRE

-13.30%

Winner

+19.72%

10Y(CAGR)

SYRE

-6.27%

Winner

+11.59%

Max(CAGR)

SYRE

-10.30%

Winner

+13.79%

SYRE vs OR - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	OR
2026	+164.19%	-3.78%
2025	+37.36%	+91.23%
2024	+8.79%	+29.95%
2023	+104.27%	+18.19%
2022	-90.57%	+2.76%
2021	-44.51%	-5.73%
2020	+1.55%	+32.40%
2019	-4.98%	+10.84%
2018	+39.22%	-22.58%
2017	+18.38%	+17.93%
2016	-55.48%	-2.30%

SYRE vs OR Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for OR was -61.89%, occurring on Mar 13, 2020. Recovery took 924 trading sessions.

The current SYRE drawdown is -73.05%. The current OR drawdown is -29.02%.

Rank	SYRE	OR
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-61.89% Sep 7, 2017 - May 11, 2021
#2	N/A	-38.15% Aug 1, 2016 - Sep 7, 2017
#3	N/A	-37.19% Jun 15, 2021 - Mar 17, 2023
#4	N/A	-34.29% May 3, 2023 - Jul 15, 2024
#5	N/A	-33.97% Mar 2, 2026 - Jun 10, 2026
#6	N/A	-24.49% Oct 7, 2025 - Jan 13, 2026
#7	N/A	-17.41% Jan 28, 2026 - Feb 26, 2026
#8	N/A	-14.86% Oct 22, 2024 - Mar 25, 2025
#9	N/A	-14.77% Apr 29, 2016 - Jun 9, 2016
#10	N/A	-14.72% Feb 8, 2016 - Apr 11, 2016
#11	N/A	-12.31% Jul 17, 2024 - Sep 20, 2024
#12	N/A	-12.18% Jan 7, 2016 - Feb 1, 2016
#13	N/A	-11.80% Jul 6, 2016 - Aug 1, 2016
#14	N/A	-8.90% Mar 31, 2025 - Apr 10, 2025
#15	N/A	-7.72% May 9, 2025 - May 20, 2025

Correlation

Correlation between SYRE and OR is -0.52 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.52

-101