SYRE vs GLXY

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Galaxy Digital (GLXY, Company).

SYRE is from the Healthcare sector, while GLXY is from the Financial Services sector.

SYRE vs GLXY - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	GLXY(COMPANY)
Market Cap	$5.92B	$5.92B
Max Drawdown	99.11%	60.71%
Sharpe Ratio	2.48	1.01
5Y Beta	1.78	3.81
Industry	Biotechnology	Capital Markets
P/E Ratio	-30.42	-20.32
Forward P/E	N/A	666.67
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-3.14%	5.00%
P/S Ratio	650.22	0.20
P/B Ratio	12.66	3.20

Market Cap

Winner

SYRE

$5.92B

GLXY

$5.92B

Max Drawdown

SYRE

99.11%

Winner

GLXY

60.71%

Sharpe Ratio

Winner

SYRE

2.48

GLXY

1.01

5Y Beta

Winner

SYRE

1.78

GLXY

3.81

Industry

SYRE

Biotechnology

GLXY

Capital Markets

P/E Ratio

Winner

SYRE

-30.42

GLXY

-20.32

Forward P/E

SYRE

N/A

GLXY

666.67

5Y EPS CAGR

SYRE

-2.15%

GLXY

N/A

Debt to Equity

SYRE

0.00%

GLXY

0.00%

Free Cash Flow Yield

SYRE

-3.14%

Winner

GLXY

5.00%

P/S Ratio

SYRE

650.22

Winner

GLXY

0.20

P/B Ratio

SYRE

12.66

Winner

GLXY

3.20

SYRE vs GLXY - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	GLXY
1 month	+11.56%	+13.58%
3 months	+89.65%	+45.58%
6 months	+150.69%	+37.04%
1 year	+386.50%	+73.62%
5 years(CAGR)	-12.61%	N/A
10 years(CAGR)	-4.61%	N/A
Max(CAGR)	-9.99%	+43.24%

SYRE

+11.56%

Winner

GLXY

+13.58%

Winner

SYRE

+89.65%

GLXY

+45.58%

Winner

SYRE

+150.69%

GLXY

+37.04%

Winner

SYRE

+386.50%

GLXY

+73.62%

5Y(CAGR)

SYRE

-12.61%

GLXY

N/A

10Y(CAGR)

SYRE

-4.61%

GLXY

N/A

Max(CAGR)

SYRE

-9.99%

Winner

GLXY

+43.24%

SYRE vs GLXY - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	GLXY
2026	+173.32%	+35.88%
2025	+37.36%	-1.93%
2024	+8.79%	N/A
2023	+104.27%	N/A
2022	-90.57%	N/A
2021	-44.51%	N/A
2020	+1.55%	N/A
2019	-4.98%	N/A
2018	+39.22%	N/A
2017	+18.38%	N/A
2016	-55.48%	N/A

SYRE vs GLXY Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for GLXY was -60.71%, occurring on Feb 5, 2026. This drawdown has not yet recovered.

The current SYRE drawdown is -72.12%. The current GLXY drawdown is -21.54%.

Rank	SYRE	GLXY
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-60.71% Oct 21, 2025 - Feb 5, 2026
#2	N/A	-28.16% Jul 24, 2025 - Sep 17, 2025
#3	N/A	-25.80% May 22, 2025 - Jul 17, 2025
#4	N/A	-10.52% Oct 9, 2025 - Oct 21, 2025
#5	N/A	-9.89% Sep 24, 2025 - Oct 1, 2025
#6	N/A	-7.36% May 19, 2025 - May 22, 2025
#7	N/A	-1.63% Sep 22, 2025 - Sep 24, 2025
#8	N/A	-0.99% Oct 2, 2025 - Oct 6, 2025
#9	N/A	-0.63% Sep 18, 2025 - Sep 22, 2025