SYRE vs GVA

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Granite Construction Inc (GVA, Company).

SYRE is from the Healthcare sector, while GVA is from the Industrials sector.

5-Year PerformanceGVA has outperformed SYRE, delivering a return of +30.0% compared to -13.3%

SYRE vs GVA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	GVA(COMPANY)
Market Cap	$5.92B	$5.94B
Max Drawdown	99.11%	86.24%
Sharpe Ratio	2.43	1.66
5Y Beta	1.75	0.86
Industry	Biotechnology	Engineering & Construction
P/E Ratio	-30.42	32.06
Forward P/E	N/A	20.58
PEG Ratio	N/A	0.65
Dividend Yield	N/A	0.38%
5Y Dividends CAGR	N/A	4.56%
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	120.24%
Free Cash Flow Yield	-3.14%	5.09%
P/S Ratio	650.22	1.31
P/B Ratio	12.66	5.75

Market Cap

SYRE

$5.92B

Winner

GVA

$5.94B

Max Drawdown

SYRE

99.11%

Winner

GVA

86.24%

Sharpe Ratio

Winner

SYRE

2.43

GVA

1.66

5Y Beta

SYRE

1.75

Winner

GVA

0.86

Industry

SYRE

Biotechnology

GVA

Engineering & Construction

P/E Ratio

Winner

SYRE

-30.42

GVA

32.06

Forward P/E

SYRE

N/A

GVA

20.58

PEG Ratio

SYRE

N/A

GVA

0.65

Dividend Yield

SYRE

N/A

GVA

0.38%

5Y Dividends CAGR

SYRE

N/A

GVA

4.56%

5Y EPS CAGR

SYRE

-2.15%

GVA

N/A

Debt to Equity

Winner

SYRE

0.00%

GVA

120.24%

Free Cash Flow Yield

SYRE

-3.14%

Winner

GVA

5.09%

P/S Ratio

SYRE

650.22

Winner

GVA

1.31

P/B Ratio

SYRE

12.66

Winner

GVA

5.75

SYRE vs GVA - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	GVA
1 month	+7.66%	+0.13%
3 months	+99.93%	+13.81%
6 months	+140.30%	+22.45%
1 year	+356.18%	+57.87%
5 years(CAGR)	-13.30%	+30.00%
10 years(CAGR)	-6.27%	+13.90%
Max(CAGR)	-10.30%	+10.94%

Winner

SYRE

+7.66%

GVA

+0.13%

Winner

SYRE

+99.93%

GVA

+13.81%

Winner

SYRE

+140.30%

GVA

+22.45%

Winner

SYRE

+356.18%

GVA

+57.87%

5Y(CAGR)

SYRE

-13.30%

Winner

GVA

+30.00%

10Y(CAGR)

SYRE

-6.27%

Winner

GVA

+13.90%

Max(CAGR)

SYRE

-10.30%

Winner

GVA

+10.94%

SYRE vs GVA - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SYRE	GVA
2026	+164.19%	+18.61%
2025	+37.36%	+31.91%
2024	+8.79%	+75.44%
2023	+104.27%	+47.00%
2022	-90.57%	-8.92%
2021	-44.51%	+47.29%
2020	+1.55%	-0.40%
2019	-4.98%	-30.47%
2018	+39.22%	-36.37%
2017	+18.38%	+16.08%
2016	-55.48%	+33.59%
2015	N/A	+17.09%
2014	N/A	+13.24%
2013	N/A	+2.04%
2012	N/A	+40.60%
2011	N/A	-13.98%
2010	N/A	-18.14%
2009	N/A	-23.70%
2008	N/A	+23.30%
2007	N/A	-27.78%
2006	N/A	+36.91%
2005	N/A	+39.27%
2004	N/A	+13.51%
2003	N/A	+43.24%
2002	N/A	-35.38%
2001	N/A	+26.31%
2000	N/A	+66.79%
1999	N/A	-5.36%

SYRE vs GVA Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for GVA was -84.73%, occurring on Mar 17, 2020. Recovery took 1580 trading sessions.

The current SYRE drawdown is -73.05%. The current GVA drawdown is -1.77%.

Rank	SYRE	GVA
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-84.73% Jan 29, 2018 - May 9, 2024
#2	N/A	-75.06% Jul 13, 2007 - Oct 27, 2017
#3	N/A	-53.23% May 14, 2001 - Jul 1, 2005
#4	N/A	-29.06% Dec 4, 2024 - Aug 7, 2025
#5	N/A	-26.75% Apr 21, 2006 - Aug 22, 2006
#6	N/A	-25.19% May 11, 2000 - Nov 17, 2000
#7	N/A	-24.25% Oct 19, 2006 - Apr 27, 2007
#8	N/A	-16.54% Nov 15, 1999 - Jan 7, 2000
#9	N/A	-16.01% Oct 3, 2005 - Nov 22, 2005
#10	N/A	-15.69% Mar 21, 2000 - May 11, 2000
#11	N/A	-14.69% Feb 24, 2026 - Apr 30, 2026
#12	N/A	-12.42% Mar 2, 2001 - Apr 10, 2001
#13	N/A	-11.45% Jan 16, 2001 - Feb 9, 2001
#14	N/A	-11.39% Aug 13, 2025 - Dec 10, 2025
#15	N/A	-10.83% May 13, 2026 - May 21, 2026

Correlation

Correlation between SYRE and GVA is -0.44 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.44

-101