SYRE vs NFG

Comparison between Spyre Therapeutics Inc (SYRE, Company) and National Fuel Gas Company (NFG, Company).

SYRE is from the Healthcare sector, while NFG is from the Energy sector.

5-Year PerformanceNFG has outperformed SYRE, delivering a return of +13.4% compared to -7.9%

SYRE vs NFG - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	NFG(COMPANY)
Market Cap	$7.72B	$7.70B
Max Drawdown	99.11%	57.73%
Sharpe Ratio	2.88	-0.29
5Y Beta	1.76	0.19
Industry	Biotechnology	Oil & Gas Integrated
P/E Ratio	-39.65	11.01
Forward P/E	N/A	9.02
PEG Ratio	N/A	0.01
Dividend Yield	N/A	2.65%
5Y Dividends CAGR	N/A	8.53%
5Y EPS CAGR	-2.15%	50.94%
Debt to Equity	0.00%	62.36%
Free Cash Flow Yield	-2.41%	3.98%
P/S Ratio	650.22	3.07
P/B Ratio	16.86	2.02

Market Cap

Winner

SYRE

$7.72B

NFG

$7.70B

Max Drawdown

SYRE

99.11%

Winner

NFG

57.73%

Sharpe Ratio

Winner

SYRE

2.88

NFG

-0.29

5Y Beta

SYRE

1.76

Winner

NFG

0.19

Industry

SYRE

Biotechnology

NFG

Oil & Gas Integrated

P/E Ratio

Winner

SYRE

-39.65

NFG

11.01

Forward P/E

SYRE

N/A

NFG

9.02

PEG Ratio

SYRE

N/A

NFG

0.01

Dividend Yield

SYRE

N/A

NFG

2.65%

5Y Dividends CAGR

SYRE

N/A

NFG

8.53%

5Y EPS CAGR

SYRE

-2.15%

Winner

NFG

50.94%

Debt to Equity

Winner

SYRE

0.00%

NFG

62.36%

Free Cash Flow Yield

SYRE

-2.41%

Winner

NFG

3.98%

P/S Ratio

SYRE

650.22

Winner

NFG

3.07

P/B Ratio

SYRE

16.86

Winner

NFG

2.02

SYRE vs NFG - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	NFG
1 month	+14.33%	+6.86%
3 months	+36.33%	-1.52%
6 months	+217.39%	-0.21%
1 year	+487.04%	-4.19%
5 years(CAGR)	-7.91%	+13.38%
10 years(CAGR)	-1.66%	+7.30%
Max(CAGR)	-8.16%	+8.12%

Winner

SYRE

+14.33%

NFG

+6.86%

Winner

SYRE

+36.33%

NFG

-1.52%

Winner

SYRE

+217.39%

NFG

-0.21%

Winner

SYRE

+487.04%

NFG

-4.19%

5Y(CAGR)

SYRE

-7.91%

Winner

NFG

+13.38%

10Y(CAGR)

SYRE

-1.66%

Winner

NFG

+7.30%

Max(CAGR)

SYRE

-8.16%

Winner

NFG

+8.12%

SYRE vs NFG - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SYRE	NFG
2026	+231.92%	+1.84%
2025	+37.36%	+33.81%
2024	+8.79%	+23.76%
2023	+104.27%	-13.90%
2022	-90.57%	+1.85%
2021	-44.51%	+60.23%
2020	+1.55%	-4.19%
2019	-4.98%	-5.35%
2018	+39.22%	-6.48%
2017	+18.38%	-0.22%
2016	-55.48%	+37.01%
2015	N/A	-37.09%
2014	N/A	+0.93%
2013	N/A	+43.49%
2012	N/A	-6.41%
2011	N/A	-14.50%
2010	N/A	+32.91%
2009	N/A	+59.71%
2008	N/A	-30.64%
2007	N/A	+26.23%
2006	N/A	+22.64%
2005	N/A	+18.36%
2004	N/A	+18.48%
2003	N/A	+21.83%
2002	N/A	-11.11%
2001	N/A	-14.55%
2000	N/A	+42.62%
1999	N/A	-5.01%

SYRE vs NFG Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for NFG was -55.49%, occurring on Nov 20, 2008. Recovery took 620 trading sessions.

The current SYRE drawdown is -66.14%. The current NFG drawdown is -13.42%.

Rank	SYRE	NFG
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-55.49% May 21, 2008 - Nov 4, 2010
#2	N/A	-50.12% Jun 30, 2014 - Dec 8, 2021
#3	N/A	-46.44% Dec 28, 2000 - Sep 7, 2004
#4	N/A	-42.88% Jul 6, 2011 - Oct 22, 2013
#5	N/A	-35.75% Jun 7, 2022 - Jan 21, 2025
#6	N/A	-23.37% Nov 15, 1999 - May 11, 2000
#7	N/A	-20.93% Apr 7, 2026 - Jun 18, 2026
#8	N/A	-19.98% Dec 10, 2007 - Apr 8, 2008
#9	N/A	-16.30% Sep 26, 2025 - Mar 2, 2026
#10	N/A	-15.12% Oct 3, 2005 - May 8, 2006
#11	N/A	-10.93% Apr 4, 2011 - Jul 6, 2011
#12	N/A	-10.50% Apr 27, 2007 - Oct 1, 2007
#13	N/A	-10.08% Oct 11, 2000 - Nov 21, 2000
#14	N/A	-9.94% Feb 18, 2014 - Jun 17, 2014
#15	N/A	-9.54% Apr 20, 2022 - May 27, 2022

Correlation

Correlation between SYRE and NFG is -0.65 which considered as a moderate negative correlation - the stocks show some tendency to move in opposite directions.

-0.65

-101