SYRE vs EMN

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Eastman Chemical Company (EMN, Company).

SYRE is from the Healthcare sector, while EMN is from the Basic Materials sector.

5-Year PerformanceEMN has outperformed SYRE, delivering a return of -5.6% compared to -7.9%

SYRE vs EMN - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	EMN(COMPANY)
Market Cap	$7.72B	$7.68B
Max Drawdown	99.11%	76.78%
Sharpe Ratio	2.88	0.02
5Y Beta	1.76	1.09
Industry	Biotechnology	Specialty Chemicals
P/E Ratio	-39.65	16.23
Forward P/E	N/A	10.57
PEG Ratio	N/A	0.58
Dividend Yield	N/A	4.90%
5Y Dividends CAGR	N/A	4.18%
5Y EPS CAGR	-2.15%	-13.84%
Debt to Equity	0.00%	86.87%
Free Cash Flow Yield	-2.41%	6.48%
P/S Ratio	650.22	0.91
P/B Ratio	16.86	1.30

Market Cap

Winner

SYRE

$7.72B

EMN

$7.68B

Max Drawdown

SYRE

99.11%

Winner

EMN

76.78%

Sharpe Ratio

Winner

SYRE

2.88

EMN

0.02

5Y Beta

SYRE

1.76

Winner

EMN

1.09

Industry

SYRE

Biotechnology

EMN

Specialty Chemicals

P/E Ratio

Winner

SYRE

-39.65

EMN

16.23

Forward P/E

SYRE

N/A

EMN

10.57

PEG Ratio

SYRE

N/A

EMN

0.58

Dividend Yield

SYRE

N/A

EMN

4.90%

5Y Dividends CAGR

SYRE

N/A

EMN

4.18%

5Y EPS CAGR

Winner

SYRE

-2.15%

EMN

-13.84%

Debt to Equity

Winner

SYRE

0.00%

EMN

86.87%

Free Cash Flow Yield

SYRE

-2.41%

Winner

EMN

6.48%

P/S Ratio

SYRE

650.22

Winner

EMN

0.91

P/B Ratio

SYRE

16.86

Winner

EMN

1.30

SYRE vs EMN - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	EMN
1 month	+14.33%	+4.61%
3 months	+36.33%	-3.06%
6 months	+217.39%	+3.45%
1 year	+487.04%	+0.20%
5 years(CAGR)	-7.91%	-5.62%
10 years(CAGR)	-1.66%	+4.12%
Max(CAGR)	-8.16%	+8.51%

Winner

SYRE

+14.33%

EMN

+4.61%

Winner

SYRE

+36.33%

EMN

-3.06%

Winner

SYRE

+217.39%

EMN

+3.45%

Winner

SYRE

+487.04%

EMN

+0.20%

5Y(CAGR)

SYRE

-7.91%

Winner

EMN

-5.62%

10Y(CAGR)

SYRE

-1.66%

Winner

EMN

+4.12%

Max(CAGR)

SYRE

-8.16%

Winner

EMN

+8.51%

SYRE vs EMN - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SYRE	EMN
2026	+231.92%	+11.46%
2025	+37.36%	-24.53%
2024	+8.79%	+5.62%
2023	+104.27%	+13.61%
2022	-90.57%	-29.62%
2021	-44.51%	+25.71%
2020	+1.55%	+32.48%
2019	-4.98%	+12.06%
2018	+39.22%	-20.50%
2017	+18.38%	+25.08%
2016	-55.48%	+15.91%
2015	N/A	-9.67%
2014	N/A	-3.84%
2013	N/A	+17.63%
2012	N/A	+72.68%
2011	N/A	-6.26%
2010	N/A	+39.87%
2009	N/A	+90.79%
2008	N/A	-45.80%
2007	N/A	+4.61%
2006	N/A	+17.28%
2005	N/A	-6.99%
2004	N/A	+51.49%
2003	N/A	+10.46%
2002	N/A	-1.78%
2001	N/A	-14.35%
2000	N/A	+9.36%
1999	N/A	+27.57%

SYRE vs EMN Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for EMN was -76.10%, occurring on Mar 5, 2009. Recovery took 588 trading sessions.

The current SYRE drawdown is -66.14%. The current EMN drawdown is -34.74%.

Rank	SYRE	EMN
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-76.10% May 20, 2008 - Sep 20, 2010
#2	N/A	-62.79% Mar 12, 2018 - Nov 24, 2020
#3	N/A	-49.36% Jan 18, 2022 - Nov 20, 2025
#4	N/A	-44.78% May 17, 2001 - Sep 30, 2004
#5	N/A	-37.68% May 10, 2011 - Feb 3, 2012
#6	N/A	-32.81% Jun 4, 2014 - Jun 13, 2017
#7	N/A	-32.78% May 22, 2000 - Mar 7, 2001
#8	N/A	-32.38% Jan 6, 2000 - Apr 28, 2000
#9	N/A	-25.48% Mar 11, 2005 - Oct 27, 2006
#10	N/A	-22.79% Jun 1, 2021 - Jan 18, 2022
#11	N/A	-20.90% Feb 28, 2012 - Aug 7, 2012
#12	N/A	-17.42% Jul 23, 2007 - Apr 8, 2008
#13	N/A	-13.98% Feb 13, 2013 - Jul 15, 2013
#14	N/A	-11.60% Oct 23, 2013 - Feb 13, 2014
#15	N/A	-11.57% Dec 28, 2004 - Feb 25, 2005