SYRE vs LQDA

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Liquidia Corp (LQDA, Company).

Both SYRE and LQDA are from the Healthcare sector.

5-Year PerformanceLQDA has outperformed SYRE, delivering a return of +95.6% compared to -13.2%

SYRE vs LQDA - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	LQDA(COMPANY)
Market Cap	$7.01B	$7B
Max Drawdown	99.11%	93.87%
Sharpe Ratio	2.86	3.08
5Y Beta	1.75	1.14
Industry	Biotechnology	Drug Manufacturers - Specialty & Generic
P/E Ratio	-36.02	329.73
Forward P/E	N/A	36.23
5Y EPS CAGR	-2.15%	N/A
Debt to Equity	0.00%	0.00%
Free Cash Flow Yield	-2.65%	0.59%

Market Cap

Winner

SYRE

$7.01B

LQDA

$7B

Max Drawdown

SYRE

99.11%

Winner

LQDA

93.87%

Sharpe Ratio

SYRE

2.86

Winner

LQDA

3.08

5Y Beta

SYRE

1.75

Winner

LQDA

1.14

Industry

SYRE

Biotechnology

LQDA

Drug Manufacturers - Specialty & Generic

P/E Ratio

Winner

SYRE

-36.02

LQDA

329.73

Forward P/E

SYRE

N/A

LQDA

36.23

5Y EPS CAGR

SYRE

-2.15%

LQDA

N/A

Debt to Equity

SYRE

0.00%

LQDA

0.00%

Free Cash Flow Yield

SYRE

-2.65%

Winner

LQDA

0.59%

SYRE vs LQDA - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	LQDA
1 month	+25.26%	+43.22%
3 months	+82.07%	+109.47%
6 months	+183.29%	+151.37%
1 year	+458.90%	+554.48%
5 years(CAGR)	-13.19%	+95.57%
10 years(CAGR)	-3.31%	N/A
Max(CAGR)	-9.63%	+28.05%

SYRE

+25.26%

Winner

LQDA

+43.22%

SYRE

+82.07%

Winner

LQDA

+109.47%

Winner

SYRE

+183.29%

LQDA

+151.37%

SYRE

+458.90%

Winner

LQDA

+554.48%

5Y(CAGR)

SYRE

-13.19%

Winner

LQDA

+95.57%

10Y(CAGR)

SYRE

-3.31%

LQDA

N/A

Max(CAGR)

SYRE

-9.63%

Winner

LQDA

+28.05%

SYRE vs LQDA - Annual Returns (2016 - 2026)

Returns include dividend reinvestment.

Year	SYRE	LQDA
2026	+183.29%	+151.37%
2025	+37.36%	+185.04%
2024	+8.79%	+1.99%
2023	+104.27%	+97.54%
2022	-90.57%	+23.93%
2021	-44.51%	+62.33%
2020	+1.55%	-32.95%
2019	-4.98%	-78.84%
2018	+39.22%	+95.14%
2017	+18.38%	N/A
2016	-55.48%	N/A

SYRE vs LQDA Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for LQDA was -93.87%, occurring on Aug 4, 2021. Recovery took 1824 trading sessions.

The current SYRE drawdown is -71.10%. The current LQDA drawdown is -1.00%.

Rank	SYRE	LQDA
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-93.87% Oct 9, 2018 - Jan 13, 2026
#2	N/A	-35.66% Feb 3, 2026 - May 11, 2026
#3	N/A	-11.16% May 28, 2026 - Jun 4, 2026
#4	N/A	-8.70% Oct 3, 2018 - Oct 9, 2018
#5	N/A	-8.64% Aug 22, 2018 - Sep 4, 2018
#6	N/A	-8.03% Sep 27, 2018 - Oct 2, 2018
#7	N/A	-6.18% Sep 11, 2018 - Sep 21, 2018
#8	N/A	-5.60% Aug 14, 2018 - Aug 17, 2018
#9	N/A	-5.28% Jun 15, 2026 - Jun 22, 2026
#10	N/A	-5.15% Jan 14, 2026 - Jan 22, 2026
#11	N/A	-4.32% Sep 5, 2018 - Sep 10, 2018
#12	N/A	-4.00% May 14, 2026 - May 19, 2026
#13	N/A	-3.90% Jun 26, 2026 - Jun 30, 2026
#14	N/A	-3.03% May 21, 2026 - May 27, 2026
#15	N/A	-1.92% Jun 22, 2026 - Jun 24, 2026