SYRE vs KEX

Comparison between Spyre Therapeutics Inc (SYRE, Company) and Kirby Corp (KEX, Company).

SYRE is from the Healthcare sector, while KEX is from the Industrials sector.

5-Year PerformanceKEX has outperformed SYRE, delivering a return of +16.3% compared to -13.2%

SYRE vs KEX - Performance Comparison

Log

Key Characteristics

Financial metrics and valuation ratios

Metric	SYRE(COMPANY)	KEX(COMPANY)
Market Cap	$7.01B	$7.03B
Max Drawdown	99.11%	75.42%
Sharpe Ratio	2.86	0.49
5Y Beta	1.75	0.99
Industry	Biotechnology	Marine Shipping
P/E Ratio	-36.02	21.16
Forward P/E	N/A	19.38
PEG Ratio	N/A	1.19
5Y EPS CAGR	-2.15%	23.95%
Debt to Equity	0.00%	28.62%
Free Cash Flow Yield	-2.65%	10.41%

Market Cap

SYRE

$7.01B

Winner

KEX

$7.03B

Max Drawdown

SYRE

99.11%

Winner

KEX

75.42%

Sharpe Ratio

Winner

SYRE

2.86

KEX

0.49

5Y Beta

SYRE

1.75

Winner

KEX

0.99

Industry

SYRE

Biotechnology

KEX

Marine Shipping

P/E Ratio

Winner

SYRE

-36.02

KEX

21.16

Forward P/E

SYRE

N/A

KEX

19.38

PEG Ratio

SYRE

N/A

KEX

1.19

5Y EPS CAGR

SYRE

-2.15%

Winner

KEX

23.95%

Debt to Equity

Winner

SYRE

0.00%

KEX

28.62%

Free Cash Flow Yield

SYRE

-2.65%

Winner

KEX

10.41%

SYRE vs KEX - Historical Returns

Returns include dividend reinvestment.

Period	SYRE	KEX
1 month	+25.26%	-9.44%
3 months	+82.07%	-4.47%
6 months	+183.29%	+16.03%
1 year	+458.90%	+10.61%
5 years(CAGR)	-13.19%	+16.31%
10 years(CAGR)	-3.31%	+7.46%
Max(CAGR)	-9.63%	+7.76%

Winner

SYRE

+25.26%

KEX

-9.44%

Winner

SYRE

+82.07%

KEX

-4.47%

Winner

SYRE

+183.29%

KEX

+16.03%

Winner

SYRE

+458.90%

KEX

+10.61%

5Y(CAGR)

SYRE

-13.19%

Winner

KEX

+16.31%

10Y(CAGR)

SYRE

-3.31%

Winner

KEX

+7.46%

Max(CAGR)

SYRE

-9.63%

Winner

KEX

+7.76%

SYRE vs KEX - Annual Returns (1999 - 2026)

Returns include dividend reinvestment.

Year	SYRE	KEX
2026	+183.29%	+16.03%
2025	+37.36%	+4.96%
2024	+8.79%	+33.94%
2023	+104.27%	+23.86%
2022	-90.57%	+7.46%
2021	-44.51%	+15.33%
2020	+1.55%	-41.72%
2019	-4.98%	+31.74%
2018	+39.22%	-0.65%
2017	+18.38%	+0.83%
2016	-55.48%	+29.83%
2015	N/A	-35.46%
2014	N/A	-16.63%
2013	N/A	+57.66%
2012	N/A	-4.68%
2011	N/A	+48.32%
2010	N/A	+26.07%
2009	N/A	+22.68%
2008	N/A	-41.14%
2007	N/A	+35.00%
2006	N/A	-35.73%
2005	N/A	+17.69%
2004	N/A	+25.90%
2003	N/A	+24.75%
2002	N/A	-2.87%
2001	N/A	+32.39%
2000	N/A	+4.69%
1999	N/A	+15.88%

SYRE vs KEX Drawdown Comparison

The maximum drawdown for SYRE was -99.11%, occurring on Jun 21, 2023. This drawdown has not yet recovered.

The maximum drawdown for KEX was -75.42%, occurring on Mar 3, 2009. Recovery took 1767 trading sessions.

The current SYRE drawdown is -71.10%. The current KEX drawdown is -14.91%.

Rank	SYRE	KEX
#1	-99.11% Apr 8, 2016 - Jun 21, 2023	-75.42% May 9, 2006 - May 17, 2013
#2	N/A	-72.25% Sep 11, 2014 - May 31, 2024
#3	N/A	-38.76% Nov 11, 2024 - Jan 22, 2026
#4	N/A	-36.23% Mar 12, 2002 - Dec 15, 2003
#5	N/A	-29.94% May 16, 2000 - May 30, 2001
#6	N/A	-17.30% Dec 21, 2004 - Jul 5, 2005
#7	N/A	-17.15% Jun 4, 2001 - Oct 15, 2001
#8	N/A	-16.99% Jul 16, 2024 - Nov 11, 2024
#9	N/A	-15.96% Jan 5, 2004 - Jun 7, 2004
#10	N/A	-14.91% Apr 29, 2026 - Jul 2, 2026
#11	N/A	-14.43% Jul 2, 2004 - Sep 30, 2004
#12	N/A	-13.92% Dec 29, 1999 - Apr 5, 2000
#13	N/A	-11.36% Jan 8, 2002 - Feb 13, 2002
#14	N/A	-9.98% Jan 22, 2026 - Feb 20, 2026
#15	N/A	-9.78% Aug 2, 2005 - Oct 3, 2005

Correlation

Correlation between SYRE and KEX is -0.43 which considered as a weak negative correlation - the stocks show a slight tendency to move in opposite directions.

-0.43

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